Elevated serum levels of human matrix metalloproteinase-9 (MMP-9) during the induction of peripheral blood stem cell mobilization by granulocyte colony-stimulating factor (G-CSF)
Abstract To investigate the role of matrix metalloproteinases (MMPs) in the mobilization of peripheral blood stem cells stimulated by granulocyte colony-stimulating factor (G-CSF), we analyzed MMP serum levels in 11 healthy donors and 9 patients who had hematological malignancies or germ cell tumors...
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| Veröffentlicht in: | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2007, Vol.13 (6), p.426-428 |
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| container_title | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy |
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| creator | Saito, Takeshi Usui, Noriko Asai, Osamu Dobashi, Nobuaki Yano, Shingo Osawa, Hiroshi Takei, Yutaka Takahara, Shinobu Ogasawara, Yoji Otsubo, Hiroko Yamaguchi, Yuko Minami, Jiro Aiba, Keisuke Hoshi, Yasutaka Kataoka, Motoyuki |
| description | Abstract To investigate the role of matrix metalloproteinases (MMPs) in the mobilization of peripheral blood stem cells stimulated by granulocyte colony-stimulating factor (G-CSF), we analyzed MMP serum levels in 11 healthy donors and 9 patients who had hematological malignancies or germ cell tumors. A dose of 5–10 µg/kg per day of G-CSF (lenograstim) was administered for 4–8 days to each subject. The serum levels of MMP-2, and MMP-9; interleukin-3, -6, -8, and -10; stem cell factor; interferon-γ; and tumor necrosis factor-α were measured both before and during G-CSF administration. MMP-9 was found to be increased in both the cancer patients and the healthy donor group. In contrast, the levels of each of the other factors tested were unchanged. No significant positive correlation was observed between the MMP-9 levels and the number of CD34+ cells. Hence, we found no significant role for MMPs during the mobilization of peripheral blood stem cells stimulated by G-CSF. |
| doi_str_mv | 10.1007/s10156-007-0553-4 |
| format | Article |
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A dose of 5–10 µg/kg per day of G-CSF (lenograstim) was administered for 4–8 days to each subject. The serum levels of MMP-2, and MMP-9; interleukin-3, -6, -8, and -10; stem cell factor; interferon-γ; and tumor necrosis factor-α were measured both before and during G-CSF administration. MMP-9 was found to be increased in both the cancer patients and the healthy donor group. In contrast, the levels of each of the other factors tested were unchanged. No significant positive correlation was observed between the MMP-9 levels and the number of CD34+ cells. Hence, we found no significant role for MMPs during the mobilization of peripheral blood stem cells stimulated by G-CSF.</description><identifier>ISSN: 1341-321X</identifier><identifier>EISSN: 1437-7780</identifier><identifier>DOI: 10.1007/s10156-007-0553-4</identifier><identifier>PMID: 18095095</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Antigens, CD34 - analysis ; Female ; Granulocyte colony-stimulating factor (G-CSF) ; Granulocyte Colony-Stimulating Factor - administration & dosage ; Granulocyte Colony-Stimulating Factor - pharmacology ; Granulocyte Colony-Stimulating Factor - therapeutic use ; Hematology, Oncology and Palliative Medicine ; Hematopoietic Stem Cell Mobilization ; Humans ; Interferon-gamma - blood ; Interleukin-8 (IL-8) ; Interleukins - blood ; Male ; Matrix Metalloproteinase 2 - blood ; Matrix Metalloproteinase 9 - blood ; Matrix metalloproteinase-9 (MMP-9) ; Middle Aged ; Mobilization ; Stem Cell Factor - blood ; Stem Cell Factor - metabolism ; Tumor Necrosis Factor-alpha - blood</subject><ispartof>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2007, Vol.13 (6), p.426-428</ispartof><rights>Japanese Society of Chemotherapy and the Japanese Association for Infectious Diseases</rights><rights>2007 Japanese Society of Chemotherapy and the Japanese Association for Infectious Diseases</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-9b447fda4997a8fff8b733454f5338b4fdcdce5cd4c27fdc7fbb66ac43e29bdd3</citedby><cites>FETCH-LOGICAL-c440t-9b447fda4997a8fff8b733454f5338b4fdcdce5cd4c27fdc7fbb66ac43e29bdd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18095095$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saito, Takeshi</creatorcontrib><creatorcontrib>Usui, Noriko</creatorcontrib><creatorcontrib>Asai, Osamu</creatorcontrib><creatorcontrib>Dobashi, Nobuaki</creatorcontrib><creatorcontrib>Yano, Shingo</creatorcontrib><creatorcontrib>Osawa, Hiroshi</creatorcontrib><creatorcontrib>Takei, Yutaka</creatorcontrib><creatorcontrib>Takahara, Shinobu</creatorcontrib><creatorcontrib>Ogasawara, Yoji</creatorcontrib><creatorcontrib>Otsubo, Hiroko</creatorcontrib><creatorcontrib>Yamaguchi, Yuko</creatorcontrib><creatorcontrib>Minami, Jiro</creatorcontrib><creatorcontrib>Aiba, Keisuke</creatorcontrib><creatorcontrib>Hoshi, Yasutaka</creatorcontrib><creatorcontrib>Kataoka, Motoyuki</creatorcontrib><title>Elevated serum levels of human matrix metalloproteinase-9 (MMP-9) during the induction of peripheral blood stem cell mobilization by granulocyte colony-stimulating factor (G-CSF)</title><title>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</title><addtitle>J Infect Chemother</addtitle><description>Abstract To investigate the role of matrix metalloproteinases (MMPs) in the mobilization of peripheral blood stem cells stimulated by granulocyte colony-stimulating factor (G-CSF), we analyzed MMP serum levels in 11 healthy donors and 9 patients who had hematological malignancies or germ cell tumors. A dose of 5–10 µg/kg per day of G-CSF (lenograstim) was administered for 4–8 days to each subject. The serum levels of MMP-2, and MMP-9; interleukin-3, -6, -8, and -10; stem cell factor; interferon-γ; and tumor necrosis factor-α were measured both before and during G-CSF administration. MMP-9 was found to be increased in both the cancer patients and the healthy donor group. In contrast, the levels of each of the other factors tested were unchanged. No significant positive correlation was observed between the MMP-9 levels and the number of CD34+ cells. Hence, we found no significant role for MMPs during the mobilization of peripheral blood stem cells stimulated by G-CSF.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antigens, CD34 - analysis</subject><subject>Female</subject><subject>Granulocyte colony-stimulating factor (G-CSF)</subject><subject>Granulocyte Colony-Stimulating Factor - administration & dosage</subject><subject>Granulocyte Colony-Stimulating Factor - pharmacology</subject><subject>Granulocyte Colony-Stimulating Factor - therapeutic use</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hematopoietic Stem Cell Mobilization</subject><subject>Humans</subject><subject>Interferon-gamma - blood</subject><subject>Interleukin-8 (IL-8)</subject><subject>Interleukins - blood</subject><subject>Male</subject><subject>Matrix Metalloproteinase 2 - blood</subject><subject>Matrix Metalloproteinase 9 - blood</subject><subject>Matrix metalloproteinase-9 (MMP-9)</subject><subject>Middle Aged</subject><subject>Mobilization</subject><subject>Stem Cell Factor - blood</subject><subject>Stem Cell Factor - metabolism</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><issn>1341-321X</issn><issn>1437-7780</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ktFqFDEUhgdRbK0-gDeSK2kvoskms5lBEGRpq9CiUAXvQiY56aZmkjXJFMfH8gnNuAuCF0IgJ_D9f3Lyn6Z5TskrSoh4nSmh7RrXEpO2ZZg_aI4pZwIL0ZGHtWacYraiX4-aJznfEUJF23WPmyPakb6t67j5de7hXhUwKEOaRlRP4DOKFm2nUQU0qpLcDzRCUd7HXYoFXFAZcI9Or68_4f4MmSm5cIvKFpALZtLFxbAY7CC53RaS8mjwMdYbCoxIg_dojIPz7qf6gw4zuk0qTD7quQDS0ccw41zcOPlKVGurdIkJnV7izc3F2dPmkVU-w7PDftJ8uTj_vHmPrz5efti8u8Kac1JwP3AurFG874XqrLXdIBjjLbctY93ArdFGQ6sN16vKaWGHYb1WmjNY9YMx7KR5ufetXX-fIBc5urw8XwWIU5brnnSrdt1WkO5BnWLOCazcJTeqNEtK5BKU3Acll3IJSvKqeXEwn4YRzF_FIZkKvNkDNQ64d5Bk1g6CBuMS6CJNdP-1f_uPWnsXnFb-G8yQ7-KUQv07SWVeSSJvlklZBoUIUZtilP0GvIy7QA</recordid><startdate>2007</startdate><enddate>2007</enddate><creator>Saito, Takeshi</creator><creator>Usui, Noriko</creator><creator>Asai, Osamu</creator><creator>Dobashi, Nobuaki</creator><creator>Yano, Shingo</creator><creator>Osawa, Hiroshi</creator><creator>Takei, Yutaka</creator><creator>Takahara, Shinobu</creator><creator>Ogasawara, Yoji</creator><creator>Otsubo, Hiroko</creator><creator>Yamaguchi, Yuko</creator><creator>Minami, Jiro</creator><creator>Aiba, Keisuke</creator><creator>Hoshi, Yasutaka</creator><creator>Kataoka, Motoyuki</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2007</creationdate><title>Elevated serum levels of human matrix metalloproteinase-9 (MMP-9) during the induction of peripheral blood stem cell mobilization by granulocyte colony-stimulating factor (G-CSF)</title><author>Saito, Takeshi ; Usui, Noriko ; Asai, Osamu ; Dobashi, Nobuaki ; Yano, Shingo ; Osawa, Hiroshi ; Takei, Yutaka ; Takahara, Shinobu ; Ogasawara, Yoji ; Otsubo, Hiroko ; Yamaguchi, Yuko ; Minami, Jiro ; Aiba, Keisuke ; Hoshi, Yasutaka ; Kataoka, Motoyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-9b447fda4997a8fff8b733454f5338b4fdcdce5cd4c27fdc7fbb66ac43e29bdd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antigens, CD34 - analysis</topic><topic>Female</topic><topic>Granulocyte colony-stimulating factor (G-CSF)</topic><topic>Granulocyte Colony-Stimulating Factor - administration & dosage</topic><topic>Granulocyte Colony-Stimulating Factor - pharmacology</topic><topic>Granulocyte Colony-Stimulating Factor - therapeutic use</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Hematopoietic Stem Cell Mobilization</topic><topic>Humans</topic><topic>Interferon-gamma - blood</topic><topic>Interleukin-8 (IL-8)</topic><topic>Interleukins - blood</topic><topic>Male</topic><topic>Matrix Metalloproteinase 2 - blood</topic><topic>Matrix Metalloproteinase 9 - blood</topic><topic>Matrix metalloproteinase-9 (MMP-9)</topic><topic>Middle Aged</topic><topic>Mobilization</topic><topic>Stem Cell Factor - blood</topic><topic>Stem Cell Factor - metabolism</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saito, Takeshi</creatorcontrib><creatorcontrib>Usui, Noriko</creatorcontrib><creatorcontrib>Asai, Osamu</creatorcontrib><creatorcontrib>Dobashi, Nobuaki</creatorcontrib><creatorcontrib>Yano, Shingo</creatorcontrib><creatorcontrib>Osawa, Hiroshi</creatorcontrib><creatorcontrib>Takei, Yutaka</creatorcontrib><creatorcontrib>Takahara, Shinobu</creatorcontrib><creatorcontrib>Ogasawara, Yoji</creatorcontrib><creatorcontrib>Otsubo, Hiroko</creatorcontrib><creatorcontrib>Yamaguchi, Yuko</creatorcontrib><creatorcontrib>Minami, Jiro</creatorcontrib><creatorcontrib>Aiba, Keisuke</creatorcontrib><creatorcontrib>Hoshi, Yasutaka</creatorcontrib><creatorcontrib>Kataoka, Motoyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saito, Takeshi</au><au>Usui, Noriko</au><au>Asai, Osamu</au><au>Dobashi, Nobuaki</au><au>Yano, Shingo</au><au>Osawa, Hiroshi</au><au>Takei, Yutaka</au><au>Takahara, Shinobu</au><au>Ogasawara, Yoji</au><au>Otsubo, Hiroko</au><au>Yamaguchi, Yuko</au><au>Minami, Jiro</au><au>Aiba, Keisuke</au><au>Hoshi, Yasutaka</au><au>Kataoka, Motoyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated serum levels of human matrix metalloproteinase-9 (MMP-9) during the induction of peripheral blood stem cell mobilization by granulocyte colony-stimulating factor (G-CSF)</atitle><jtitle>Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy</jtitle><addtitle>J Infect Chemother</addtitle><date>2007</date><risdate>2007</risdate><volume>13</volume><issue>6</issue><spage>426</spage><epage>428</epage><pages>426-428</pages><issn>1341-321X</issn><eissn>1437-7780</eissn><abstract>Abstract To investigate the role of matrix metalloproteinases (MMPs) in the mobilization of peripheral blood stem cells stimulated by granulocyte colony-stimulating factor (G-CSF), we analyzed MMP serum levels in 11 healthy donors and 9 patients who had hematological malignancies or germ cell tumors. A dose of 5–10 µg/kg per day of G-CSF (lenograstim) was administered for 4–8 days to each subject. The serum levels of MMP-2, and MMP-9; interleukin-3, -6, -8, and -10; stem cell factor; interferon-γ; and tumor necrosis factor-α were measured both before and during G-CSF administration. MMP-9 was found to be increased in both the cancer patients and the healthy donor group. In contrast, the levels of each of the other factors tested were unchanged. No significant positive correlation was observed between the MMP-9 levels and the number of CD34+ cells. Hence, we found no significant role for MMPs during the mobilization of peripheral blood stem cells stimulated by G-CSF.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>18095095</pmid><doi>10.1007/s10156-007-0553-4</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 1341-321X |
| ispartof | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2007, Vol.13 (6), p.426-428 |
| issn | 1341-321X 1437-7780 |
| language | eng |
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| subjects | Adolescent Adult Aged Antigens, CD34 - analysis Female Granulocyte colony-stimulating factor (G-CSF) Granulocyte Colony-Stimulating Factor - administration & dosage Granulocyte Colony-Stimulating Factor - pharmacology Granulocyte Colony-Stimulating Factor - therapeutic use Hematology, Oncology and Palliative Medicine Hematopoietic Stem Cell Mobilization Humans Interferon-gamma - blood Interleukin-8 (IL-8) Interleukins - blood Male Matrix Metalloproteinase 2 - blood Matrix Metalloproteinase 9 - blood Matrix metalloproteinase-9 (MMP-9) Middle Aged Mobilization Stem Cell Factor - blood Stem Cell Factor - metabolism Tumor Necrosis Factor-alpha - blood |
| title | Elevated serum levels of human matrix metalloproteinase-9 (MMP-9) during the induction of peripheral blood stem cell mobilization by granulocyte colony-stimulating factor (G-CSF) |
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