Interleukin-10 Expression in Macrophages during Phagocytosis of Apoptotic Cells Is Mediated by Homeodomain Proteins Pbx1 and Prep-1

Production of interleukin (IL)-10, a major immunoregulatory cytokine, by phagocytes during clearance of apoptotic cells is critical to ensuring cellular homeostasis and suppression of autoimmunity. Little is known about the regulatory mechanisms in this fundamental process. We report that IL-10 prod...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2007-12, Vol.27 (6), p.952-964
Hauptverfasser:	Chung, Elaine Y., Liu, Jianguo, Homma, Yoichiro, Zhang, Yunhua, Brendolan, Andrea, Saggese, Matilde, Han, Jihong, Silverstein, Roy, Selleri, Licia, Ma, Xiaojing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis CD36 Antigens - physiology Cytokines DNA - metabolism DNA-Binding Proteins - physiology E coli Gene expression Homeodomain Proteins - physiology Humans Immune system Interleukin-10 - biosynthesis Interleukin-10 - genetics Kinases Lupus Macrophages - immunology Mice Mice, Inbred C57BL MOLIMMUNO p38 Mitogen-Activated Protein Kinases - physiology PBX Phagocytosis Pre-B-Cell Leukemia Transcription Factor 1 Promoter Regions, Genetic Proteins Proto-Oncogene Proteins - physiology Rodents Transcription factors Transcription Factors - physiology Transcription, Genetic
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