Interleukin-10 Expression in Macrophages during Phagocytosis of Apoptotic Cells Is Mediated by Homeodomain Proteins Pbx1 and Prep-1
Production of interleukin (IL)-10, a major immunoregulatory cytokine, by phagocytes during clearance of apoptotic cells is critical to ensuring cellular homeostasis and suppression of autoimmunity. Little is known about the regulatory mechanisms in this fundamental process. We report that IL-10 prod...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 2007-12, Vol.27 (6), p.952-964 |
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| container_title | Immunity (Cambridge, Mass.) |
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| creator | Chung, Elaine Y. Liu, Jianguo Homma, Yoichiro Zhang, Yunhua Brendolan, Andrea Saggese, Matilde Han, Jihong Silverstein, Roy Selleri, Licia Ma, Xiaojing |
| description | Production of interleukin (IL)-10, a major immunoregulatory cytokine, by phagocytes during clearance of apoptotic cells is critical to ensuring cellular homeostasis and suppression of autoimmunity. Little is known about the regulatory mechanisms in this fundamental process. We report that IL-10 production stimulated by apoptotic cells was regulated at the point of transcription in a manner dependent on p38 mitogen-activated protein kinase, partially on the scavenger receptor CD36, and required cell-cell contact but not phagocytosis. By using a reporter assay, we mapped the apoptotic-cell-response element (ACRE) in the human
IL10 promoter and provide biochemical and physiological evidence that ACRE mediates the transcriptional activation of
IL10 by pre-B cell leukemia transcription factor-1b and another Hox cofactor Pbx-regulating protein 1 in response to apoptotic cells. This study establishes a role of two developmentally critical factors (Pbx1 and Prep-1) in the regulation of homeostasis in the immune system. |
| doi_str_mv | 10.1016/j.immuni.2007.11.014 |
| format | Article |
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IL10 promoter and provide biochemical and physiological evidence that ACRE mediates the transcriptional activation of
IL10 by pre-B cell leukemia transcription factor-1b and another Hox cofactor Pbx-regulating protein 1 in response to apoptotic cells. This study establishes a role of two developmentally critical factors (Pbx1 and Prep-1) in the regulation of homeostasis in the immune system.</description><identifier>ISSN: 1074-7613</identifier><identifier>EISSN: 1097-4180</identifier><identifier>DOI: 10.1016/j.immuni.2007.11.014</identifier><identifier>PMID: 18093541</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Apoptosis ; CD36 Antigens - physiology ; Cytokines ; DNA - metabolism ; DNA-Binding Proteins - physiology ; E coli ; Gene expression ; Homeodomain Proteins - physiology ; Humans ; Immune system ; Interleukin-10 - biosynthesis ; Interleukin-10 - genetics ; Kinases ; Lupus ; Macrophages - immunology ; Mice ; Mice, Inbred C57BL ; MOLIMMUNO ; p38 Mitogen-Activated Protein Kinases - physiology ; PBX ; Phagocytosis ; Pre-B-Cell Leukemia Transcription Factor 1 ; Promoter Regions, Genetic ; Proteins ; Proto-Oncogene Proteins - physiology ; Rodents ; Transcription factors ; Transcription Factors - physiology ; Transcription, Genetic</subject><ispartof>Immunity (Cambridge, Mass.), 2007-12, Vol.27 (6), p.952-964</ispartof><rights>2007 Elsevier Inc.</rights><rights>Copyright Elsevier Limited Dec 21, 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c531t-3b086a67282121e669664cfaac9d13495879fb1655172c0f5726487e3e2eba033</citedby><cites>FETCH-LOGICAL-c531t-3b086a67282121e669664cfaac9d13495879fb1655172c0f5726487e3e2eba033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.immuni.2007.11.014$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18093541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, Elaine Y.</creatorcontrib><creatorcontrib>Liu, Jianguo</creatorcontrib><creatorcontrib>Homma, Yoichiro</creatorcontrib><creatorcontrib>Zhang, Yunhua</creatorcontrib><creatorcontrib>Brendolan, Andrea</creatorcontrib><creatorcontrib>Saggese, Matilde</creatorcontrib><creatorcontrib>Han, Jihong</creatorcontrib><creatorcontrib>Silverstein, Roy</creatorcontrib><creatorcontrib>Selleri, Licia</creatorcontrib><creatorcontrib>Ma, Xiaojing</creatorcontrib><title>Interleukin-10 Expression in Macrophages during Phagocytosis of Apoptotic Cells Is Mediated by Homeodomain Proteins Pbx1 and Prep-1</title><title>Immunity (Cambridge, Mass.)</title><addtitle>Immunity</addtitle><description>Production of interleukin (IL)-10, a major immunoregulatory cytokine, by phagocytes during clearance of apoptotic cells is critical to ensuring cellular homeostasis and suppression of autoimmunity. Little is known about the regulatory mechanisms in this fundamental process. We report that IL-10 production stimulated by apoptotic cells was regulated at the point of transcription in a manner dependent on p38 mitogen-activated protein kinase, partially on the scavenger receptor CD36, and required cell-cell contact but not phagocytosis. By using a reporter assay, we mapped the apoptotic-cell-response element (ACRE) in the human
IL10 promoter and provide biochemical and physiological evidence that ACRE mediates the transcriptional activation of
IL10 by pre-B cell leukemia transcription factor-1b and another Hox cofactor Pbx-regulating protein 1 in response to apoptotic cells. This study establishes a role of two developmentally critical factors (Pbx1 and Prep-1) in the regulation of homeostasis in the immune system.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>CD36 Antigens - physiology</subject><subject>Cytokines</subject><subject>DNA - metabolism</subject><subject>DNA-Binding Proteins - physiology</subject><subject>E coli</subject><subject>Gene expression</subject><subject>Homeodomain Proteins - physiology</subject><subject>Humans</subject><subject>Immune system</subject><subject>Interleukin-10 - biosynthesis</subject><subject>Interleukin-10 - genetics</subject><subject>Kinases</subject><subject>Lupus</subject><subject>Macrophages - immunology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>MOLIMMUNO</subject><subject>p38 Mitogen-Activated Protein Kinases - physiology</subject><subject>PBX</subject><subject>Phagocytosis</subject><subject>Pre-B-Cell Leukemia Transcription Factor 1</subject><subject>Promoter Regions, Genetic</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins - physiology</subject><subject>Rodents</subject><subject>Transcription factors</subject><subject>Transcription Factors - physiology</subject><subject>Transcription, Genetic</subject><issn>1074-7613</issn><issn>1097-4180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxiMEoqXwBghZQuKWMOMkdnJBqlaFrtSKPcDZcpxJ8bKxg52g7gPwHn2WPhle7UpIHODkf7_5Zvx9WfYaoUBA8X5b2HFcnC04gCwQC8DqSXaO0Mq8wgaeHvayyqXA8ix7EeMWElG38Dw7S89tWVd4nv1au5nCjpbv1uUI7Op-ChSj9Y5Zx261CX76pu8osn4J1t09PmzS0Zv97KONzA_scvLT7Gdr2Ip2u8jWkd1Sb_VMPev2jw_XfiTf-1EnvU3wM1kX2aa7R6Zdn25oyvFl9mzQu0ivTutF9vXj1ZfVdX7z-dN6dXmTm7rEOS87aIQWkjccOZIQrRCVGbQ2bY9l1daNbIcORV2j5AaGWnJRNZJK4tRpKMuL7N1Rdwr-x0JxVqONJo2tHfklKtFCcoa3_wU5yEYCHhTf_gVu_RJc-oTCGiouII2QqOpIJTtjDDSoKdhRh71CUIc01VYd01SHNBWiSlmlsjcn8aUbqf9TdIovAR-OACXTfloKKhpLziT_A5lZ9d7-u8NvWVSzCw</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>Chung, Elaine Y.</creator><creator>Liu, Jianguo</creator><creator>Homma, Yoichiro</creator><creator>Zhang, Yunhua</creator><creator>Brendolan, Andrea</creator><creator>Saggese, Matilde</creator><creator>Han, Jihong</creator><creator>Silverstein, Roy</creator><creator>Selleri, Licia</creator><creator>Ma, Xiaojing</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20071201</creationdate><title>Interleukin-10 Expression in Macrophages during Phagocytosis of Apoptotic Cells Is Mediated by Homeodomain Proteins Pbx1 and Prep-1</title><author>Chung, Elaine Y. ; 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Little is known about the regulatory mechanisms in this fundamental process. We report that IL-10 production stimulated by apoptotic cells was regulated at the point of transcription in a manner dependent on p38 mitogen-activated protein kinase, partially on the scavenger receptor CD36, and required cell-cell contact but not phagocytosis. By using a reporter assay, we mapped the apoptotic-cell-response element (ACRE) in the human
IL10 promoter and provide biochemical and physiological evidence that ACRE mediates the transcriptional activation of
IL10 by pre-B cell leukemia transcription factor-1b and another Hox cofactor Pbx-regulating protein 1 in response to apoptotic cells. This study establishes a role of two developmentally critical factors (Pbx1 and Prep-1) in the regulation of homeostasis in the immune system.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18093541</pmid><doi>10.1016/j.immuni.2007.11.014</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Apoptosis CD36 Antigens - physiology Cytokines DNA - metabolism DNA-Binding Proteins - physiology E coli Gene expression Homeodomain Proteins - physiology Humans Immune system Interleukin-10 - biosynthesis Interleukin-10 - genetics Kinases Lupus Macrophages - immunology Mice Mice, Inbred C57BL MOLIMMUNO p38 Mitogen-Activated Protein Kinases - physiology PBX Phagocytosis Pre-B-Cell Leukemia Transcription Factor 1 Promoter Regions, Genetic Proteins Proto-Oncogene Proteins - physiology Rodents Transcription factors Transcription Factors - physiology Transcription, Genetic |
| title | Interleukin-10 Expression in Macrophages during Phagocytosis of Apoptotic Cells Is Mediated by Homeodomain Proteins Pbx1 and Prep-1 |
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