Gene Expression-Based Molecular Diagnostic System for Malignant Gliomas Is Superior to Histological Diagnosis

Purpose: Current morphology-based glioma classification methods do not adequately reflect the complex biology of gliomas, thus limiting their prognostic ability. In this study, we focused on anaplastic oligodendroglioma and glioblastoma, which typically follow distinct clinical courses. Our goal was...

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Veröffentlicht in:	Clinical cancer research 2007-12, Vol.13 (24), p.7341-7356
Hauptverfasser:	SHIRAHATA, Mitsuaki, IWAO-KOIZUMI, Kyoko, SAITO, Sakae, UENO, Noriko, ODA, Masashi, HASHIMOTO, Nobuo, TAKAHASHI, Jun A, KATO, Kikuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Antineoplastic agents Biological and medical sciences Brain Neoplasms - classification Brain Neoplasms - diagnosis Brain Neoplasms - genetics Clinical Trials, Phase II as Topic Gene Expression gene expression profiling Gene Expression Profiling - methods Glioblastoma - classification Glioblastoma - diagnosis Glioblastoma - genetics Humans Kaplan-Meier Estimate Loss of Heterozygosity malignant glioma Medical sciences molecular diagnosis Neurology Oligodendroglioma - diagnosis Oligodendroglioma - genetics Oligodendroglioma - mortality Oligonucleotide Array Sequence Analysis Pharmacology. Drug treatments Polymerase Chain Reaction Prognosis Reproducibility of Results Sensitivity and Specificity Tumors of the nervous system. Phacomatoses
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