Cleavage of the human thyrotropin receptor by ADAM10 is regulated by thyrotropin

The thyrotropin receptor (TSHR) has a unique 50 residue (317–366) ectodomain insertion that sets it apart from other glycoprotein hormone receptors (GPHRs). Other ancient members of the leucine‐rich repeat G protein‐coupled receptor (GPCR) (LGR) family do exhibit ectodomain insertions of variable le...

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Veröffentlicht in:	Journal of molecular recognition 2007-09, Vol.20 (5), p.392-404
Hauptverfasser:	Kaczur, Viktoria, Puskas, Laszlo. G., Nagy, Zsuzsanna U., Miled, Nabil, Rebai, Ahmed, Juhasz, Ferenc, Kupihar, Zoltan, Zvara, Agnes, Hackler Jr, Laszlo, Farid, Nadir R.
Format:	Artikel
Sprache:	eng
Schlagworte:	50 residue insertion A-subunit ADAM Proteins - metabolism ADAM10 ADAM10 Protein Amino Acid Sequence Amyloid Precursor Protein Secretases - metabolism Animals Cattle CHO Cells cleavage enzyme Cricetinae Cricetulus DNA microarray Gene Expression Regulation - drug effects Humans Membrane Proteins - metabolism Models, Biological Models, Molecular Molecular Sequence Data Peptides - metabolism Protein Subunits - metabolism Receptors, Thyrotropin - chemistry Receptors, Thyrotropin - metabolism Sequence Homology, Amino Acid Substrate Specificity - drug effects Thyrotropin - pharmacology thyrotropin receptor TSHR substrate peptide
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