Cardiac sympathetic denervation in bradykinesia-dominant Parkinsonʼs disease
Cardiac iodine-123-labeled-metaiodobenzylguanidine uptake is reduced in early-stage Parkinsonʼs disease, suggesting sympathetic nerve degeneration. The scintigraphic findings in patients with Parkinsonʼs disease with different clinical features have, however, not been established. Iodine-123-labeled...
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| Veröffentlicht in: | Neuroreport 2007-11, Vol.18 (17), p.1867-1870 |
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| creator | Suzuki, Masahiko Urashima, Mitsuyoshi Oka, Hisayoshi Hashimoto, Masaya Taira, Kenichiro |
| description | Cardiac iodine-123-labeled-metaiodobenzylguanidine uptake is reduced in early-stage Parkinsonʼs disease, suggesting sympathetic nerve degeneration. The scintigraphic findings in patients with Parkinsonʼs disease with different clinical features have, however, not been established. Iodine-123-labeled-metaiodobenzylguanidine myocardial scintigraphy was performed in 143 patients with Parkinsonʼs disease. The early and delayed heart to mediastinum ratios were analyzed according to the dominant motor deficit (tremor, bradykinesia, rigidity, and postural instability), age, sex, age at onset, disease duration, and Hoehn and Yahr stage. Both ratios correlated with bradykinesia, age at disease onset, and disease duration; but not with sex, Hoehn and Yahr stage, tremor, rigidity, and postural instability. Our results suggest a close link between myocardial sympathetic degeneration and bradykinesia, age at onset and disease duration. |
| doi_str_mv | 10.1097/WNR.0b013e3282f1ab33 |
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The scintigraphic findings in patients with Parkinsonʼs disease with different clinical features have, however, not been established. Iodine-123-labeled-metaiodobenzylguanidine myocardial scintigraphy was performed in 143 patients with Parkinsonʼs disease. The early and delayed heart to mediastinum ratios were analyzed according to the dominant motor deficit (tremor, bradykinesia, rigidity, and postural instability), age, sex, age at onset, disease duration, and Hoehn and Yahr stage. Both ratios correlated with bradykinesia, age at disease onset, and disease duration; but not with sex, Hoehn and Yahr stage, tremor, rigidity, and postural instability. Our results suggest a close link between myocardial sympathetic degeneration and bradykinesia, age at onset and disease duration.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/WNR.0b013e3282f1ab33</identifier><identifier>PMID: 18090328</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>3-Iodobenzylguanidine - pharmacokinetics ; Adult ; Adult and adolescent clinical studies ; Age of Onset ; Aged ; Aged, 80 and over ; Autonomic Nervous System Diseases - diagnostic imaging ; Autonomic Nervous System Diseases - etiology ; Autonomic Nervous System Diseases - physiopathology ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Heart - innervation ; Heart - physiopathology ; Humans ; Hypokinesia - complications ; Hypokinesia - diagnostic imaging ; Hypokinesia - physiopathology ; Male ; Mediastinum - physiopathology ; Medical sciences ; Middle Aged ; Myocardium - metabolism ; Neurology ; Organic mental disorders. Neuropsychology ; Parkinson Disease - complications ; Parkinson Disease - diagnostic imaging ; Parkinson Disease - physiopathology ; Phenotype ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Radionuclide Imaging ; Radiopharmaceuticals - pharmacokinetics ; Regression Analysis</subject><ispartof>Neuroreport, 2007-11, Vol.18 (17), p.1867-1870</ispartof><rights>2007 Lippincott Williams & Wilkins, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3803-7c73cead89390a6385f025413ecca099b84331eaae714e7c8b2425248a7081043</citedby><cites>FETCH-LOGICAL-c3803-7c73cead89390a6385f025413ecca099b84331eaae714e7c8b2425248a7081043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19202798$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18090328$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suzuki, Masahiko</creatorcontrib><creatorcontrib>Urashima, Mitsuyoshi</creatorcontrib><creatorcontrib>Oka, Hisayoshi</creatorcontrib><creatorcontrib>Hashimoto, Masaya</creatorcontrib><creatorcontrib>Taira, Kenichiro</creatorcontrib><title>Cardiac sympathetic denervation in bradykinesia-dominant Parkinsonʼs disease</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>Cardiac iodine-123-labeled-metaiodobenzylguanidine uptake is reduced in early-stage Parkinsonʼs disease, suggesting sympathetic nerve degeneration. The scintigraphic findings in patients with Parkinsonʼs disease with different clinical features have, however, not been established. Iodine-123-labeled-metaiodobenzylguanidine myocardial scintigraphy was performed in 143 patients with Parkinsonʼs disease. The early and delayed heart to mediastinum ratios were analyzed according to the dominant motor deficit (tremor, bradykinesia, rigidity, and postural instability), age, sex, age at onset, disease duration, and Hoehn and Yahr stage. Both ratios correlated with bradykinesia, age at disease onset, and disease duration; but not with sex, Hoehn and Yahr stage, tremor, rigidity, and postural instability. Our results suggest a close link between myocardial sympathetic degeneration and bradykinesia, age at onset and disease duration.</description><subject>3-Iodobenzylguanidine - pharmacokinetics</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Autonomic Nervous System Diseases - diagnostic imaging</subject><subject>Autonomic Nervous System Diseases - etiology</subject><subject>Autonomic Nervous System Diseases - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Heart - innervation</subject><subject>Heart - physiopathology</subject><subject>Humans</subject><subject>Hypokinesia - complications</subject><subject>Hypokinesia - diagnostic imaging</subject><subject>Hypokinesia - physiopathology</subject><subject>Male</subject><subject>Mediastinum - physiopathology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardium - metabolism</subject><subject>Neurology</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - diagnostic imaging</subject><subject>Parkinson Disease - physiopathology</subject><subject>Phenotype</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Radionuclide Imaging</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Regression Analysis</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkd1q3DAQhUVpSTZp3qAU3zR3Tkc_XkmXYUmaQvpDSGnvxFges2pseSN5G_bd-gR9qqpkYaFXMwzfOcOcYewNhwsOVr___vnuAlrgkqQwoufYSvmCLbjSsm4a8-MlW4BtbK3ssjlmJzn_BAAL3ByxY25KV2QL9mmFqQvoq7wbNzivaQ6-6ihS-oVzmGIVYtUm7HYPIVIOWHfTGCLGufqKqczyFP_8zlUXMmGm1-xVj0Oms309Zd-ur-5XN_Xtlw8fV5e3tZcGZK29lp6wM1ZawKU0TQ-iUeUU7xGsbY2SkhMiaa5Ie9MKJRqhDGowHJQ8ZefPvps0PW4pz24M2dMwYKRpm93SgjbFsYDqGfRpyjlR7zYpjJh2joP7F6MrMbr_Yyyyt3v_bTtSdxDtcyvAuz2A2ePQJ4w-5ANnBQhtzWH_0zTMlPLDsH2i5NaEw7x25SHAdbOsBYDmnFuoy0RI-ReE74zb</recordid><startdate>20071119</startdate><enddate>20071119</enddate><creator>Suzuki, Masahiko</creator><creator>Urashima, Mitsuyoshi</creator><creator>Oka, Hisayoshi</creator><creator>Hashimoto, Masaya</creator><creator>Taira, Kenichiro</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071119</creationdate><title>Cardiac sympathetic denervation in bradykinesia-dominant Parkinsonʼs disease</title><author>Suzuki, Masahiko ; Urashima, Mitsuyoshi ; Oka, Hisayoshi ; Hashimoto, Masaya ; Taira, Kenichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3803-7c73cead89390a6385f025413ecca099b84331eaae714e7c8b2425248a7081043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>3-Iodobenzylguanidine - pharmacokinetics</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Autonomic Nervous System Diseases - diagnostic imaging</topic><topic>Autonomic Nervous System Diseases - etiology</topic><topic>Autonomic Nervous System Diseases - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Heart - innervation</topic><topic>Heart - physiopathology</topic><topic>Humans</topic><topic>Hypokinesia - complications</topic><topic>Hypokinesia - diagnostic imaging</topic><topic>Hypokinesia - physiopathology</topic><topic>Male</topic><topic>Mediastinum - physiopathology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardium - metabolism</topic><topic>Neurology</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - diagnostic imaging</topic><topic>Parkinson Disease - physiopathology</topic><topic>Phenotype</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Radionuclide Imaging</topic><topic>Radiopharmaceuticals - pharmacokinetics</topic><topic>Regression Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suzuki, Masahiko</creatorcontrib><creatorcontrib>Urashima, Mitsuyoshi</creatorcontrib><creatorcontrib>Oka, Hisayoshi</creatorcontrib><creatorcontrib>Hashimoto, Masaya</creatorcontrib><creatorcontrib>Taira, Kenichiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suzuki, Masahiko</au><au>Urashima, Mitsuyoshi</au><au>Oka, Hisayoshi</au><au>Hashimoto, Masaya</au><au>Taira, Kenichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac sympathetic denervation in bradykinesia-dominant Parkinsonʼs disease</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>2007-11-19</date><risdate>2007</risdate><volume>18</volume><issue>17</issue><spage>1867</spage><epage>1870</epage><pages>1867-1870</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>Cardiac iodine-123-labeled-metaiodobenzylguanidine uptake is reduced in early-stage Parkinsonʼs disease, suggesting sympathetic nerve degeneration. The scintigraphic findings in patients with Parkinsonʼs disease with different clinical features have, however, not been established. Iodine-123-labeled-metaiodobenzylguanidine myocardial scintigraphy was performed in 143 patients with Parkinsonʼs disease. The early and delayed heart to mediastinum ratios were analyzed according to the dominant motor deficit (tremor, bradykinesia, rigidity, and postural instability), age, sex, age at onset, disease duration, and Hoehn and Yahr stage. Both ratios correlated with bradykinesia, age at disease onset, and disease duration; but not with sex, Hoehn and Yahr stage, tremor, rigidity, and postural instability. Our results suggest a close link between myocardial sympathetic degeneration and bradykinesia, age at onset and disease duration.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>18090328</pmid><doi>10.1097/WNR.0b013e3282f1ab33</doi><tpages>4</tpages></addata></record> |
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| subjects | 3-Iodobenzylguanidine - pharmacokinetics Adult Adult and adolescent clinical studies Age of Onset Aged Aged, 80 and over Autonomic Nervous System Diseases - diagnostic imaging Autonomic Nervous System Diseases - etiology Autonomic Nervous System Diseases - physiopathology Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Heart - innervation Heart - physiopathology Humans Hypokinesia - complications Hypokinesia - diagnostic imaging Hypokinesia - physiopathology Male Mediastinum - physiopathology Medical sciences Middle Aged Myocardium - metabolism Neurology Organic mental disorders. Neuropsychology Parkinson Disease - complications Parkinson Disease - diagnostic imaging Parkinson Disease - physiopathology Phenotype Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radionuclide Imaging Radiopharmaceuticals - pharmacokinetics Regression Analysis |
| title | Cardiac sympathetic denervation in bradykinesia-dominant Parkinsonʼs disease |
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