Expression of phosphodiesterase 4 is altered in the brains of subjects with autism

The cyclic adenosine monophosphate-specific phosphodiesterase-4 (PDE4) gene family is the target of several potential therapeutic inhibitors and the PDE4B gene has been associated with schizophrenia and depression. Little, however, is known of any connection between this gene family and autism, with...

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Veröffentlicht in:	Neuroreport 2007-11, Vol.18 (17), p.1841-1844
Hauptverfasser:	Braun, Natalie N, Reutiman, Teri J, Lee, Susanne, Folsom, Timothy D, Fatemi, S Hossein
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Autistic Disorder - enzymology Autistic Disorder - genetics Biological and medical sciences Blotting, Western Brain - enzymology Cerebellum - enzymology Cerebral Cortex - enzymology Child clinical studies Cyclic Nucleotide Phosphodiesterases, Type 4 - biosynthesis Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics Data Interpretation, Statistical Developmental disorders Electrophoresis, Polyacrylamide Gel Female Humans Infantile autism Isoenzymes - biosynthesis Isoenzymes - genetics Male Medical sciences Middle Aged Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia
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