Intra-parenchymal injection of tumor necrosis factor-alpha and interleukin 1-beta produces dopamine neuron loss in the rat

Inflammatory processes are thought to underlie the dopamine (DA) neuron loss seen in Parkinson's disease (PD). However, it is not known if the inflammation precedes that loss, or is a consequence of it. We injected tumor necrosis factor alpha (TNFalpha) and interleukin 1 beta (IL-1beta) into th...

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Veröffentlicht in:	Journal of Neural Transmission 2005-05, Vol.112 (5), p.601-612
Hauptverfasser:	Carvey, P M, Chen, E-Y, Lipton, J W, Tong, C W, Chang, Q A, Ling, Z D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Death - drug effects Dopamine - metabolism Dose-Response Relationship, Drug Injections, Intraventricular Interleukin-1 - administration & dosage Male Neurons - drug effects Neurons - pathology Rats Substantia Nigra - drug effects Substantia Nigra - pathology Tumor Necrosis Factor-alpha - administration & dosage
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