A Single Nucleotide Polymorphism in the Carboxylesterase Gene Is Associated with the Responsiveness to Imidapril Medication and the Promoter Activity

Imidapril is an angiotensin-converting enzyme inhibitor that is widely used in treating hypertension, although the responses vary among individuals. We investigated whether a single nucleotide polymorphism at position −816 of the carboxylesterase 1 (CES1) gene, which activates imidapril in the liver...

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Veröffentlicht in:	Hypertension research 2005-09, Vol.28 (9), p.719-725
Hauptverfasser:	Geshi, Eiichi, Kimura, Tomomi, Yoshimura, Mika, Suzuki, Hiroshi, Koba, Shinji, Sakai, Tetsuo, Saito, Tsukasa, Koga, Atsuro, Muramatsu, Masaaki, Katagiri, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Angiotensin-Converting Enzyme Inhibitors - therapeutic use Antihypertensive Agents - therapeutic use Carboxylesterase - genetics Female Genotype Geriatrics/Gerontology Health Promotion and Disease Prevention Humans Hypertension - drug therapy Hypertension - genetics Imidazolidines - therapeutic use Internal Medicine Male Medicine Medicine & Public Health Middle Aged Obstetrics/Perinatology/Midwifery original-article Polymorphism, Single Nucleotide Promoter Regions, Genetic Public Health
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