Prognostic value of tumor necrosis factor-alpha in patients with ST-segment elevation acute myocardial infarction
Tumor necrosis factor-alpha (TNFalpha in patients with ST-segment elevation myocardial infarction (STEMI). The aim of this study was to determine the prognostic value of TNFalpha in this clinical setting at six-month follow-up. The levels of TNFalpha, C-reactive protein (CRP), interleukin 6 and type...
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| Veröffentlicht in: | Revista española de cardiologia 2007-12, Vol.60 (12), p.1233-1241 |
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| creator | Gonzálvez, Manuel Ruiz-Ros, José A Pérez-Paredes, Matías Lozano, María L García-Almagro, Francisco J Martínez-Corbalán, Francisco Giménez, Diego M Carrillo, Andrés Carnero, Andrés Cubero, Tomás Gonzálvez, Juan J Ureña, Isabel Vicente, Vicente |
| description | Tumor necrosis factor-alpha (TNFalpha in patients with ST-segment elevation myocardial infarction (STEMI). The aim of this study was to determine the prognostic value of TNFalpha in this clinical setting at six-month follow-up.
The levels of TNFalpha, C-reactive protein (CRP), interleukin 6 and type 1 soluble intercellular adhesion molecules measured within the first 10 h of symptom onset and at 48 h in 74 consecutive patients admitted with STEMI. The relationships between these levels and the incidence of ischemic events (i.e., angina, reinfarction, and death), heart failure (HF), or both (i.e., all cardiovascular events) were studied.
Overall, TNFalpha levels were significantly higher in patients who had an ischemic event or HF than in those who did not (P |
| doi_str_mv | 10.1157/13113928 |
| format | Article |
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The levels of TNFalpha, C-reactive protein (CRP), interleukin 6 and type 1 soluble intercellular adhesion molecules measured within the first 10 h of symptom onset and at 48 h in 74 consecutive patients admitted with STEMI. The relationships between these levels and the incidence of ischemic events (i.e., angina, reinfarction, and death), heart failure (HF), or both (i.e., all cardiovascular events) were studied.
Overall, TNFalpha levels were significantly higher in patients who had an ischemic event or HF than in those who did not (P<.02 for both). At 48 h, the adjusted odds ratios of those in the highest TNFalpha quartile (2.92 pg/mL) for the development of ischemic events, HF, and all cardiovascular events combined were 13.1, 9.59 and 9.75, respectively. A TNFalpha level of 2.04 pg/mL at 48 h had a sensitivity of 78% and a specificity of 72.5% in predicting a cardiovascular event of any form. The CRP level, but not the TNFalpha level, at admission was found to be an independent predictor of the development of a cardiovascular events.
In patients with STEMI, the plasma TNFalpha level 48 h after symptom onset and the CRP level at admission were independent predictors of cardiovascular events.</description><identifier>EISSN: 1579-2242</identifier><identifier>DOI: 10.1157/13113928</identifier><identifier>PMID: 18082088</identifier><language>spa</language><publisher>Spain</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Angina Pectoris - blood ; Angina Pectoris - etiology ; Angina Pectoris - mortality ; Biomarkers - blood ; C-Reactive Protein - analysis ; Epidemiologic Methods ; Female ; Heart Failure - blood ; Heart Failure - etiology ; Heart Failure - mortality ; Humans ; Interleukin-6 - blood ; Male ; Middle Aged ; Myocardial Infarction - blood ; Myocardial Infarction - complications ; Myocardial Infarction - mortality ; Prognosis ; Recurrence ; Time Factors ; Tumor Necrosis Factor-alpha - blood ; Vascular Cell Adhesion Molecule-1 - blood</subject><ispartof>Revista española de cardiologia, 2007-12, Vol.60 (12), p.1233-1241</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18082088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gonzálvez, Manuel</creatorcontrib><creatorcontrib>Ruiz-Ros, José A</creatorcontrib><creatorcontrib>Pérez-Paredes, Matías</creatorcontrib><creatorcontrib>Lozano, María L</creatorcontrib><creatorcontrib>García-Almagro, Francisco J</creatorcontrib><creatorcontrib>Martínez-Corbalán, Francisco</creatorcontrib><creatorcontrib>Giménez, Diego M</creatorcontrib><creatorcontrib>Carrillo, Andrés</creatorcontrib><creatorcontrib>Carnero, Andrés</creatorcontrib><creatorcontrib>Cubero, Tomás</creatorcontrib><creatorcontrib>Gonzálvez, Juan J</creatorcontrib><creatorcontrib>Ureña, Isabel</creatorcontrib><creatorcontrib>Vicente, Vicente</creatorcontrib><title>Prognostic value of tumor necrosis factor-alpha in patients with ST-segment elevation acute myocardial infarction</title><title>Revista española de cardiologia</title><addtitle>Rev Esp Cardiol</addtitle><description>Tumor necrosis factor-alpha (TNFalpha in patients with ST-segment elevation myocardial infarction (STEMI). The aim of this study was to determine the prognostic value of TNFalpha in this clinical setting at six-month follow-up.
The levels of TNFalpha, C-reactive protein (CRP), interleukin 6 and type 1 soluble intercellular adhesion molecules measured within the first 10 h of symptom onset and at 48 h in 74 consecutive patients admitted with STEMI. The relationships between these levels and the incidence of ischemic events (i.e., angina, reinfarction, and death), heart failure (HF), or both (i.e., all cardiovascular events) were studied.
Overall, TNFalpha levels were significantly higher in patients who had an ischemic event or HF than in those who did not (P<.02 for both). At 48 h, the adjusted odds ratios of those in the highest TNFalpha quartile (2.92 pg/mL) for the development of ischemic events, HF, and all cardiovascular events combined were 13.1, 9.59 and 9.75, respectively. A TNFalpha level of 2.04 pg/mL at 48 h had a sensitivity of 78% and a specificity of 72.5% in predicting a cardiovascular event of any form. The CRP level, but not the TNFalpha level, at admission was found to be an independent predictor of the development of a cardiovascular events.
In patients with STEMI, the plasma TNFalpha level 48 h after symptom onset and the CRP level at admission were independent predictors of cardiovascular events.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angina Pectoris - blood</subject><subject>Angina Pectoris - etiology</subject><subject>Angina Pectoris - mortality</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>Heart Failure - blood</subject><subject>Heart Failure - etiology</subject><subject>Heart Failure - mortality</subject><subject>Humans</subject><subject>Interleukin-6 - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - mortality</subject><subject>Prognosis</subject><subject>Recurrence</subject><subject>Time Factors</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Vascular Cell Adhesion Molecule-1 - blood</subject><issn>1579-2242</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kN1LwzAUxYMgbk7Bv0Dy5Fs1H02bPsrwCwYKzueSJTdbJG1qkk7231txPl3OOb97uRyErii5pVTUd5RTyhsmT9B8kk3BWMlm6DylT0KY4GV5hmZUEsmIlHP09RbDtg8pO433yo-Ag8V57ELEPegYkkvYKp1DLJQfdgq7Hg8qO-hzwt8u7_D7ukiw7SYDg4f9lIUeKz1mwN0haBWNU35asyrq3-wCnVrlE1we5wJ9PD6sl8_F6vXpZXm_Kobp_VxApa1mshHEMs0rxZQRwnBJAcCwup58oUu9MZIIQhUX0jIwVWlKTSSxmi_Qzd_dIYavEVJuO5c0eK96CGNqq4bUhJV0Aq-P4LjpwLRDdJ2Kh_a_JP4DL3doYA</recordid><startdate>200712</startdate><enddate>200712</enddate><creator>Gonzálvez, Manuel</creator><creator>Ruiz-Ros, José A</creator><creator>Pérez-Paredes, Matías</creator><creator>Lozano, María L</creator><creator>García-Almagro, Francisco J</creator><creator>Martínez-Corbalán, Francisco</creator><creator>Giménez, Diego M</creator><creator>Carrillo, Andrés</creator><creator>Carnero, Andrés</creator><creator>Cubero, Tomás</creator><creator>Gonzálvez, Juan J</creator><creator>Ureña, Isabel</creator><creator>Vicente, Vicente</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200712</creationdate><title>Prognostic value of tumor necrosis factor-alpha in patients with ST-segment elevation acute myocardial infarction</title><author>Gonzálvez, Manuel ; Ruiz-Ros, José A ; Pérez-Paredes, Matías ; Lozano, María L ; García-Almagro, Francisco J ; Martínez-Corbalán, Francisco ; Giménez, Diego M ; Carrillo, Andrés ; Carnero, Andrés ; Cubero, Tomás ; Gonzálvez, Juan J ; Ureña, Isabel ; Vicente, Vicente</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p139t-e6cfc28950f2c36a2ad55d381eeed27750f5c4cbd80501a358f2ed64d4c080fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angina Pectoris - blood</topic><topic>Angina Pectoris - etiology</topic><topic>Angina Pectoris - mortality</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - analysis</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>Heart Failure - blood</topic><topic>Heart Failure - etiology</topic><topic>Heart Failure - mortality</topic><topic>Humans</topic><topic>Interleukin-6 - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - complications</topic><topic>Myocardial Infarction - mortality</topic><topic>Prognosis</topic><topic>Recurrence</topic><topic>Time Factors</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Vascular Cell Adhesion Molecule-1 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gonzálvez, Manuel</creatorcontrib><creatorcontrib>Ruiz-Ros, José A</creatorcontrib><creatorcontrib>Pérez-Paredes, Matías</creatorcontrib><creatorcontrib>Lozano, María L</creatorcontrib><creatorcontrib>García-Almagro, Francisco J</creatorcontrib><creatorcontrib>Martínez-Corbalán, Francisco</creatorcontrib><creatorcontrib>Giménez, Diego M</creatorcontrib><creatorcontrib>Carrillo, Andrés</creatorcontrib><creatorcontrib>Carnero, Andrés</creatorcontrib><creatorcontrib>Cubero, Tomás</creatorcontrib><creatorcontrib>Gonzálvez, Juan J</creatorcontrib><creatorcontrib>Ureña, Isabel</creatorcontrib><creatorcontrib>Vicente, Vicente</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Revista española de cardiologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gonzálvez, Manuel</au><au>Ruiz-Ros, José A</au><au>Pérez-Paredes, Matías</au><au>Lozano, María L</au><au>García-Almagro, Francisco J</au><au>Martínez-Corbalán, Francisco</au><au>Giménez, Diego M</au><au>Carrillo, Andrés</au><au>Carnero, Andrés</au><au>Cubero, Tomás</au><au>Gonzálvez, Juan J</au><au>Ureña, Isabel</au><au>Vicente, Vicente</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of tumor necrosis factor-alpha in patients with ST-segment elevation acute myocardial infarction</atitle><jtitle>Revista española de cardiologia</jtitle><addtitle>Rev Esp Cardiol</addtitle><date>2007-12</date><risdate>2007</risdate><volume>60</volume><issue>12</issue><spage>1233</spage><epage>1241</epage><pages>1233-1241</pages><eissn>1579-2242</eissn><abstract>Tumor necrosis factor-alpha (TNFalpha in patients with ST-segment elevation myocardial infarction (STEMI). The aim of this study was to determine the prognostic value of TNFalpha in this clinical setting at six-month follow-up.
The levels of TNFalpha, C-reactive protein (CRP), interleukin 6 and type 1 soluble intercellular adhesion molecules measured within the first 10 h of symptom onset and at 48 h in 74 consecutive patients admitted with STEMI. The relationships between these levels and the incidence of ischemic events (i.e., angina, reinfarction, and death), heart failure (HF), or both (i.e., all cardiovascular events) were studied.
Overall, TNFalpha levels were significantly higher in patients who had an ischemic event or HF than in those who did not (P<.02 for both). At 48 h, the adjusted odds ratios of those in the highest TNFalpha quartile (2.92 pg/mL) for the development of ischemic events, HF, and all cardiovascular events combined were 13.1, 9.59 and 9.75, respectively. A TNFalpha level of 2.04 pg/mL at 48 h had a sensitivity of 78% and a specificity of 72.5% in predicting a cardiovascular event of any form. The CRP level, but not the TNFalpha level, at admission was found to be an independent predictor of the development of a cardiovascular events.
In patients with STEMI, the plasma TNFalpha level 48 h after symptom onset and the CRP level at admission were independent predictors of cardiovascular events.</abstract><cop>Spain</cop><pmid>18082088</pmid><doi>10.1157/13113928</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Aged, 80 and over Angina Pectoris - blood Angina Pectoris - etiology Angina Pectoris - mortality Biomarkers - blood C-Reactive Protein - analysis Epidemiologic Methods Female Heart Failure - blood Heart Failure - etiology Heart Failure - mortality Humans Interleukin-6 - blood Male Middle Aged Myocardial Infarction - blood Myocardial Infarction - complications Myocardial Infarction - mortality Prognosis Recurrence Time Factors Tumor Necrosis Factor-alpha - blood Vascular Cell Adhesion Molecule-1 - blood |
| title | Prognostic value of tumor necrosis factor-alpha in patients with ST-segment elevation acute myocardial infarction |
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