Treatment With Anti‐γ‐Glutamyl Transpeptidase Antibody Attenuates Osteolysis in Collagen‐Induced Arthritis Mice

The effectiveness of a new antibody treatment on arthritis‐associated osteolysis was studied by using CIA mice. GGT, a newly identified bone‐resorbing factor, was upregulated in arthritic joints. We generated monoclonal antibodies against GGT and injected them into CIA mice. Mice treated with antibo...

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Veröffentlicht in:	Journal of bone and mineral research 2007-12, Vol.22 (12), p.1933-1942
Hauptverfasser:	Ishizuka, Yasuyuki, Moriwaki, Sawako, Kawahara‐Hanaoka, Miyuki, Uemura, Yasunori, Serizawa, Isao, Miyauchi, Mutsumi, Shibata, Shunichi, Kanaya, Toshimichi, Takata, Takashi, Taniguchi, Naoyuki, Niida, Shumpei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology antibody therapy arthritis Arthritis, Experimental - drug therapy Arthritis, Experimental - enzymology Arthritis, Experimental - pathology Biological and medical sciences Cells, Cultured Cytokines - antagonists & inhibitors Cytokines - metabolism Fundamental and applied biological sciences. Psychology gamma-Glutamyltransferase - antagonists & inhibitors gamma-Glutamyltransferase - metabolism Humans Inflammation - drug therapy Inflammation - enzymology Inflammation - pathology Lymphocytes - enzymology Lymphocytes - pathology Mice Mice, Inbred BALB C Osteoblasts - enzymology Osteoblasts - pathology osteoclast Osteoclasts - enzymology Osteoclasts - metabolism Osteoclasts - pathology osteolysis Osteolysis - drug therapy Osteolysis - enzymology Osteolysis - pathology RANK Ligand - biosynthesis Rats Rats, Wistar Skeleton and joints Stem Cells - enzymology Stem Cells - pathology Vertebrates: osteoarticular system, musculoskeletal system γ‐glutamyl transpeptidase
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