A Single‐Center, Open‐Label Study on the Use of Injectable Poly‐l‐lactic Acid for the Treatment of Moderate to Severe Scarring from Acne or Varicella
BACKGROUND AND OBJECTIVE Acne scars may negatively impact quality of life. The purpose of this study was to collect preliminary data on the efficacy and safety of injectable poly‐l‐lactic acid (PLLA, Sculptra, Dermik Laboratories) for the treatment of acne scars. METHODS Twenty subjects aged 42.4±10...
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| Veröffentlicht in: | Dermatologic surgery 2007-12, Vol.33, p.S159-S167 |
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| container_title | Dermatologic surgery |
| container_volume | 33 |
| creator | BEER, KENNETH |
| description | BACKGROUND AND OBJECTIVE
Acne scars may negatively impact quality of life. The purpose of this study was to collect preliminary data on the efficacy and safety of injectable poly‐l‐lactic acid (PLLA, Sculptra, Dermik Laboratories) for the treatment of acne scars.
METHODS
Twenty subjects aged 42.4±10.7 years (10 men, 10 women) with facial scars resulting from moderate to severe acne or varicella participated in this single‐center, open‐label prospective study. The primary end point was the resolution of the acne or varicella scars. Secondary end points were the physician and subject assessments of scar improvement. PLLA reconstituted with 5 mL of sterile water was injected serially at or near the sites of the acne scars without topical anesthesia.
RESULTS
Investigator‐assessed reductions in acne scar size and severity were significant (p |
| doi_str_mv | 10.1111/j.1524-4725.2007.33356.x |
| format | Article |
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Acne scars may negatively impact quality of life. The purpose of this study was to collect preliminary data on the efficacy and safety of injectable poly‐l‐lactic acid (PLLA, Sculptra, Dermik Laboratories) for the treatment of acne scars.
METHODS
Twenty subjects aged 42.4±10.7 years (10 men, 10 women) with facial scars resulting from moderate to severe acne or varicella participated in this single‐center, open‐label prospective study. The primary end point was the resolution of the acne or varicella scars. Secondary end points were the physician and subject assessments of scar improvement. PLLA reconstituted with 5 mL of sterile water was injected serially at or near the sites of the acne scars without topical anesthesia.
RESULTS
Investigator‐assessed reductions in acne scar size and severity were significant (p<.0001) during the course of seven treatments. Subject‐rated reduction in scar severity was also significant (p=.0078). Subject satisfaction with treatment trended toward an increase with each treatment session and approached significance (p=.0899). Adverse events were limited to depression (n=1) not related to the treatment.
CONCLUSION
Injectable PLLA as used in this investigation appears to correct the types of acne scars treated in this study without serious adverse effects.</description><identifier>ISSN: 1076-0512</identifier><identifier>EISSN: 1524-4725</identifier><identifier>DOI: 10.1111/j.1524-4725.2007.33356.x</identifier><identifier>PMID: 18086054</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Acne Vulgaris - complications ; Adult ; Biocompatible Materials - therapeutic use ; Chickenpox - complications ; Cicatrix - drug therapy ; Cicatrix - etiology ; Cosmetic Techniques ; Face ; Female ; Humans ; Injections ; Lactic Acid - therapeutic use ; Male ; Polyesters ; Polymers - therapeutic use ; Prospective Studies ; Quality of Life ; Treatment Outcome</subject><ispartof>Dermatologic surgery, 2007-12, Vol.33, p.S159-S167</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3196-39af4bfc3f4d99187776f26ce6e0621a32d73902cfc6ebc4aa80037cc3d479c53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1524-4725.2007.33356.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1524-4725.2007.33356.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18086054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BEER, KENNETH</creatorcontrib><title>A Single‐Center, Open‐Label Study on the Use of Injectable Poly‐l‐lactic Acid for the Treatment of Moderate to Severe Scarring from Acne or Varicella</title><title>Dermatologic surgery</title><addtitle>Dermatol Surg</addtitle><description>BACKGROUND AND OBJECTIVE
Acne scars may negatively impact quality of life. The purpose of this study was to collect preliminary data on the efficacy and safety of injectable poly‐l‐lactic acid (PLLA, Sculptra, Dermik Laboratories) for the treatment of acne scars.
METHODS
Twenty subjects aged 42.4±10.7 years (10 men, 10 women) with facial scars resulting from moderate to severe acne or varicella participated in this single‐center, open‐label prospective study. The primary end point was the resolution of the acne or varicella scars. Secondary end points were the physician and subject assessments of scar improvement. PLLA reconstituted with 5 mL of sterile water was injected serially at or near the sites of the acne scars without topical anesthesia.
RESULTS
Investigator‐assessed reductions in acne scar size and severity were significant (p<.0001) during the course of seven treatments. Subject‐rated reduction in scar severity was also significant (p=.0078). Subject satisfaction with treatment trended toward an increase with each treatment session and approached significance (p=.0899). Adverse events were limited to depression (n=1) not related to the treatment.
CONCLUSION
Injectable PLLA as used in this investigation appears to correct the types of acne scars treated in this study without serious adverse effects.</description><subject>Acne Vulgaris - complications</subject><subject>Adult</subject><subject>Biocompatible Materials - therapeutic use</subject><subject>Chickenpox - complications</subject><subject>Cicatrix - drug therapy</subject><subject>Cicatrix - etiology</subject><subject>Cosmetic Techniques</subject><subject>Face</subject><subject>Female</subject><subject>Humans</subject><subject>Injections</subject><subject>Lactic Acid - therapeutic use</subject><subject>Male</subject><subject>Polyesters</subject><subject>Polymers - therapeutic use</subject><subject>Prospective Studies</subject><subject>Quality of Life</subject><subject>Treatment Outcome</subject><issn>1076-0512</issn><issn>1524-4725</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc1u1DAUhS1ERUvhFZBXrEjqv9jjDdJoyk-lqYqUDlvLca4hoyQeHA90djwCL8DL8SQ40xYsWb7W_c65lg9CmJKS5nWxLWnFRCEUq0pGiCo555Us756gs3-Np7kmShakouwUPZ-mLSGUaU6eoVO6IAtJKnGGfi9x3Y1fevjz89cKxgTxDb7ZwZiva9tAj-u0bw84jDh9BbyZAAePr8YtuGSbHvCn0B8y28_butQ5vHRdi32IR8FtBJuG7DvLrkML0SbAKeAavkMEXDsbY56PfQxDlo7ZP-LPNnYO-t6-QCfe9hO8fDjP0eb9u9vVx2J98-FqtVwXjlMtC66tF4133ItWa7pQSknPpAMJRDJqOWsV14Q57yQ0Tli7IIQr53grlHYVP0ev7313MXzbw5TM0E3HF4wQ9pORmkgtqMjgqwdw3wzQml3sBhsP5vFDM_D2HvjR9XD43ydmDs5szZyPmfMxc3DmGJy5M5f15ljyv8AYkGw</recordid><startdate>200712</startdate><enddate>200712</enddate><creator>BEER, KENNETH</creator><general>Blackwell Publishing Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200712</creationdate><title>A Single‐Center, Open‐Label Study on the Use of Injectable Poly‐l‐lactic Acid for the Treatment of Moderate to Severe Scarring from Acne or Varicella</title><author>BEER, KENNETH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3196-39af4bfc3f4d99187776f26ce6e0621a32d73902cfc6ebc4aa80037cc3d479c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Acne Vulgaris - complications</topic><topic>Adult</topic><topic>Biocompatible Materials - therapeutic use</topic><topic>Chickenpox - complications</topic><topic>Cicatrix - drug therapy</topic><topic>Cicatrix - etiology</topic><topic>Cosmetic Techniques</topic><topic>Face</topic><topic>Female</topic><topic>Humans</topic><topic>Injections</topic><topic>Lactic Acid - therapeutic use</topic><topic>Male</topic><topic>Polyesters</topic><topic>Polymers - therapeutic use</topic><topic>Prospective Studies</topic><topic>Quality of Life</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BEER, KENNETH</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatologic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BEER, KENNETH</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Single‐Center, Open‐Label Study on the Use of Injectable Poly‐l‐lactic Acid for the Treatment of Moderate to Severe Scarring from Acne or Varicella</atitle><jtitle>Dermatologic surgery</jtitle><addtitle>Dermatol Surg</addtitle><date>2007-12</date><risdate>2007</risdate><volume>33</volume><spage>S159</spage><epage>S167</epage><pages>S159-S167</pages><issn>1076-0512</issn><eissn>1524-4725</eissn><abstract>BACKGROUND AND OBJECTIVE
Acne scars may negatively impact quality of life. The purpose of this study was to collect preliminary data on the efficacy and safety of injectable poly‐l‐lactic acid (PLLA, Sculptra, Dermik Laboratories) for the treatment of acne scars.
METHODS
Twenty subjects aged 42.4±10.7 years (10 men, 10 women) with facial scars resulting from moderate to severe acne or varicella participated in this single‐center, open‐label prospective study. The primary end point was the resolution of the acne or varicella scars. Secondary end points were the physician and subject assessments of scar improvement. PLLA reconstituted with 5 mL of sterile water was injected serially at or near the sites of the acne scars without topical anesthesia.
RESULTS
Investigator‐assessed reductions in acne scar size and severity were significant (p<.0001) during the course of seven treatments. Subject‐rated reduction in scar severity was also significant (p=.0078). Subject satisfaction with treatment trended toward an increase with each treatment session and approached significance (p=.0899). Adverse events were limited to depression (n=1) not related to the treatment.
CONCLUSION
Injectable PLLA as used in this investigation appears to correct the types of acne scars treated in this study without serious adverse effects.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>18086054</pmid><doi>10.1111/j.1524-4725.2007.33356.x</doi><tpages>9</tpages></addata></record> |
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| ispartof | Dermatologic surgery, 2007-12, Vol.33, p.S159-S167 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Journals@Ovid Complete |
| subjects | Acne Vulgaris - complications Adult Biocompatible Materials - therapeutic use Chickenpox - complications Cicatrix - drug therapy Cicatrix - etiology Cosmetic Techniques Face Female Humans Injections Lactic Acid - therapeutic use Male Polyesters Polymers - therapeutic use Prospective Studies Quality of Life Treatment Outcome |
| title | A Single‐Center, Open‐Label Study on the Use of Injectable Poly‐l‐lactic Acid for the Treatment of Moderate to Severe Scarring from Acne or Varicella |
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