EFFECT OF HUMAN SPLENIC CONTRACTION ON VARIATION IN CIRCULATING BLOOD CELL COUNTS

SUMMARY 1. The human spleen sequesters 200–250 mL densely packed red blood cells. Up to 50% of this viscous blood is actively expelled into the systemic circulation during strenuous exercise or simulated apnoea (breath‐hold) diving. The contribution of splenic contraction to changes in the circulati...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Clinical and experimental pharmacology & physiology 2005-11, Vol.32 (11), p.944-951
Hauptverfasser: Baković, Darija, Eterović, Davor, Saratlija-Novaković, XXXana, Palada, Ivan, Valic, Zoran, Bilopavlović, Nada, Dujić, XXXeljko
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 951
container_issue 11
container_start_page 944
container_title Clinical and experimental pharmacology & physiology
container_volume 32
creator Baković, Darija
Eterović, Davor
Saratlija-Novaković, XXXana
Palada, Ivan
Valic, Zoran
Bilopavlović, Nada
Dujić, XXXeljko
description SUMMARY 1. The human spleen sequesters 200–250 mL densely packed red blood cells. Up to 50% of this viscous blood is actively expelled into the systemic circulation during strenuous exercise or simulated apnoea (breath‐hold) diving. The contribution of splenic contraction to changes in the circulating volume of red blood cells (RBCV), as well as the venous concentration of white blood cells (WBC) and platelets (PLT), was investigated following repeated breath‐hold apnoeas. 2. Eighteen trained apnoea divers and 18 intact and six splenectomized subjects without diving experience repeated five maximal apnoeas with face immersion in cold water, with 2 min intervals between successive attempts. Venous blood samples were taken before and between consecutive apnoeas, as well as at 0, 10 and 20 min after the last breath hold. Arterial pressure, heart rate and transcutaneous partial pressure of oxygen and carbon dioxide were monitored continuously. 3. Plasma protein concentration decreased by 5.8, 2.2 and 9% in apnoea divers, untrained and splenectomized subjects, respectively, indicating an expansion of plasma volume. The RBCV and venous concentration of WBC, corrected for changes in plasma volume, increased in both trained apnoea divers (4.9 ± 1.0 and 14.9 ± 3.1%, respectively) and intact subjects (1.7 ± 0.8 and 7.2 ± 1.8%, respectively), whereas in splenectomized subjects there was no change in RBCV and a delayed increase in WBC concentration. Furthermore, an initial lymphocytosis detected during repeated breath holds in divers and intact subjects was completely absent in splenectomized subjects. None of the groups showed significant changes in PLT concentrations. The well‐recognized diving response to apnoea (bradycardia and increased blood pressure) was seen during all breath‐hold attempts in all subjects. 4. Repeated breath‐holds (apnoeas) contribute to increased RBCV and venous blood concentrations of WBC through splenic contraction.
doi_str_mv 10.1111/j.1440-1681.2005.04289.x
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69068571</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69068571</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4059-a66e7073e6525a1939c1572162b2a5b498c20f86d43cc39d28ffa707f82ab9c83</originalsourceid><addsrcrecordid>eNqNkEFv2yAUx9G0qU27foWJ0252H2AwPuzgMie15OHOdTZpF0QcLCVLls40avrti5uouw4h8Z74_96TfghhAjEJ53odkySBiAhJYgrAY0iozOLDOzR5-3iPJsCAR0SmcI4uvF9DSIJgZ-iciAR4wskEfS-m00K1uJ7i2_m3XOP7u6rQpcKq1m2Tq7asNQ73R96U-WtTaqzKRs2r0OoZvqnq-itWRVUFZK7b-4_oQ2833l2d3ks0nxatuo2qelaqvIq6sDuLrBAuhZQ5wSm3JGNZR3hKiaALavkiyWRHoZdimbCuY9mSyr63AegltYusk-wSfT7OfRh2f_fOP5rtyndus7F_3G7vjchASJ6SEJTHYDfsvB9cbx6G1dYOz4aAGXWatRmtmdGaGXWaV53mENBPpx37xdYt_4EnfyHw5Rh4Wm3c838PNqq4G6vAR0d-5R_d4Y23w28jUpZy81PPDIC4aRpNzC_2AnobiYQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69068571</pqid></control><display><type>article</type><title>EFFECT OF HUMAN SPLENIC CONTRACTION ON VARIATION IN CIRCULATING BLOOD CELL COUNTS</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Baković, Darija ; Eterović, Davor ; Saratlija-Novaković, XXXana ; Palada, Ivan ; Valic, Zoran ; Bilopavlović, Nada ; Dujić, XXXeljko</creator><creatorcontrib>Baković, Darija ; Eterović, Davor ; Saratlija-Novaković, XXXana ; Palada, Ivan ; Valic, Zoran ; Bilopavlović, Nada ; Dujić, XXXeljko</creatorcontrib><description>SUMMARY 1. The human spleen sequesters 200–250 mL densely packed red blood cells. Up to 50% of this viscous blood is actively expelled into the systemic circulation during strenuous exercise or simulated apnoea (breath‐hold) diving. The contribution of splenic contraction to changes in the circulating volume of red blood cells (RBCV), as well as the venous concentration of white blood cells (WBC) and platelets (PLT), was investigated following repeated breath‐hold apnoeas. 2. Eighteen trained apnoea divers and 18 intact and six splenectomized subjects without diving experience repeated five maximal apnoeas with face immersion in cold water, with 2 min intervals between successive attempts. Venous blood samples were taken before and between consecutive apnoeas, as well as at 0, 10 and 20 min after the last breath hold. Arterial pressure, heart rate and transcutaneous partial pressure of oxygen and carbon dioxide were monitored continuously. 3. Plasma protein concentration decreased by 5.8, 2.2 and 9% in apnoea divers, untrained and splenectomized subjects, respectively, indicating an expansion of plasma volume. The RBCV and venous concentration of WBC, corrected for changes in plasma volume, increased in both trained apnoea divers (4.9 ± 1.0 and 14.9 ± 3.1%, respectively) and intact subjects (1.7 ± 0.8 and 7.2 ± 1.8%, respectively), whereas in splenectomized subjects there was no change in RBCV and a delayed increase in WBC concentration. Furthermore, an initial lymphocytosis detected during repeated breath holds in divers and intact subjects was completely absent in splenectomized subjects. None of the groups showed significant changes in PLT concentrations. The well‐recognized diving response to apnoea (bradycardia and increased blood pressure) was seen during all breath‐hold attempts in all subjects. 4. Repeated breath‐holds (apnoeas) contribute to increased RBCV and venous blood concentrations of WBC through splenic contraction.</description><identifier>ISSN: 0305-1870</identifier><identifier>EISSN: 1440-1681</identifier><identifier>DOI: 10.1111/j.1440-1681.2005.04289.x</identifier><identifier>PMID: 16405451</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Pty</publisher><subject>Adult ; Apnea - blood ; Blood Cell Count ; Blood Gas Monitoring, Transcutaneous ; Blood Pressure ; Blood Proteins - metabolism ; Carbon Dioxide - blood ; Diving ; erythrocyte ; Female ; Heart Rate ; Hematocrit ; human ; Humans ; leucocyte ; Leukocyte Count ; Male ; plasma volume ; platelet ; repeated breath-hold ; simulated apnoea diving ; Spleen - physiology ; Splenectomy ; splenic contraction ; Time Factors</subject><ispartof>Clinical and experimental pharmacology &amp; physiology, 2005-11, Vol.32 (11), p.944-951</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4059-a66e7073e6525a1939c1572162b2a5b498c20f86d43cc39d28ffa707f82ab9c83</citedby><cites>FETCH-LOGICAL-c4059-a66e7073e6525a1939c1572162b2a5b498c20f86d43cc39d28ffa707f82ab9c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1681.2005.04289.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1681.2005.04289.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16405451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baković, Darija</creatorcontrib><creatorcontrib>Eterović, Davor</creatorcontrib><creatorcontrib>Saratlija-Novaković, XXXana</creatorcontrib><creatorcontrib>Palada, Ivan</creatorcontrib><creatorcontrib>Valic, Zoran</creatorcontrib><creatorcontrib>Bilopavlović, Nada</creatorcontrib><creatorcontrib>Dujić, XXXeljko</creatorcontrib><title>EFFECT OF HUMAN SPLENIC CONTRACTION ON VARIATION IN CIRCULATING BLOOD CELL COUNTS</title><title>Clinical and experimental pharmacology &amp; physiology</title><addtitle>Clin Exp Pharmacol Physiol</addtitle><description>SUMMARY 1. The human spleen sequesters 200–250 mL densely packed red blood cells. Up to 50% of this viscous blood is actively expelled into the systemic circulation during strenuous exercise or simulated apnoea (breath‐hold) diving. The contribution of splenic contraction to changes in the circulating volume of red blood cells (RBCV), as well as the venous concentration of white blood cells (WBC) and platelets (PLT), was investigated following repeated breath‐hold apnoeas. 2. Eighteen trained apnoea divers and 18 intact and six splenectomized subjects without diving experience repeated five maximal apnoeas with face immersion in cold water, with 2 min intervals between successive attempts. Venous blood samples were taken before and between consecutive apnoeas, as well as at 0, 10 and 20 min after the last breath hold. Arterial pressure, heart rate and transcutaneous partial pressure of oxygen and carbon dioxide were monitored continuously. 3. Plasma protein concentration decreased by 5.8, 2.2 and 9% in apnoea divers, untrained and splenectomized subjects, respectively, indicating an expansion of plasma volume. The RBCV and venous concentration of WBC, corrected for changes in plasma volume, increased in both trained apnoea divers (4.9 ± 1.0 and 14.9 ± 3.1%, respectively) and intact subjects (1.7 ± 0.8 and 7.2 ± 1.8%, respectively), whereas in splenectomized subjects there was no change in RBCV and a delayed increase in WBC concentration. Furthermore, an initial lymphocytosis detected during repeated breath holds in divers and intact subjects was completely absent in splenectomized subjects. None of the groups showed significant changes in PLT concentrations. The well‐recognized diving response to apnoea (bradycardia and increased blood pressure) was seen during all breath‐hold attempts in all subjects. 4. Repeated breath‐holds (apnoeas) contribute to increased RBCV and venous blood concentrations of WBC through splenic contraction.</description><subject>Adult</subject><subject>Apnea - blood</subject><subject>Blood Cell Count</subject><subject>Blood Gas Monitoring, Transcutaneous</subject><subject>Blood Pressure</subject><subject>Blood Proteins - metabolism</subject><subject>Carbon Dioxide - blood</subject><subject>Diving</subject><subject>erythrocyte</subject><subject>Female</subject><subject>Heart Rate</subject><subject>Hematocrit</subject><subject>human</subject><subject>Humans</subject><subject>leucocyte</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>plasma volume</subject><subject>platelet</subject><subject>repeated breath-hold</subject><subject>simulated apnoea diving</subject><subject>Spleen - physiology</subject><subject>Splenectomy</subject><subject>splenic contraction</subject><subject>Time Factors</subject><issn>0305-1870</issn><issn>1440-1681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFv2yAUx9G0qU27foWJ0252H2AwPuzgMie15OHOdTZpF0QcLCVLls40avrti5uouw4h8Z74_96TfghhAjEJ53odkySBiAhJYgrAY0iozOLDOzR5-3iPJsCAR0SmcI4uvF9DSIJgZ-iciAR4wskEfS-m00K1uJ7i2_m3XOP7u6rQpcKq1m2Tq7asNQ73R96U-WtTaqzKRs2r0OoZvqnq-itWRVUFZK7b-4_oQ2833l2d3ks0nxatuo2qelaqvIq6sDuLrBAuhZQ5wSm3JGNZR3hKiaALavkiyWRHoZdimbCuY9mSyr63AegltYusk-wSfT7OfRh2f_fOP5rtyndus7F_3G7vjchASJ6SEJTHYDfsvB9cbx6G1dYOz4aAGXWatRmtmdGaGXWaV53mENBPpx37xdYt_4EnfyHw5Rh4Wm3c838PNqq4G6vAR0d-5R_d4Y23w28jUpZy81PPDIC4aRpNzC_2AnobiYQ</recordid><startdate>200511</startdate><enddate>200511</enddate><creator>Baković, Darija</creator><creator>Eterović, Davor</creator><creator>Saratlija-Novaković, XXXana</creator><creator>Palada, Ivan</creator><creator>Valic, Zoran</creator><creator>Bilopavlović, Nada</creator><creator>Dujić, XXXeljko</creator><general>Blackwell Science Pty</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200511</creationdate><title>EFFECT OF HUMAN SPLENIC CONTRACTION ON VARIATION IN CIRCULATING BLOOD CELL COUNTS</title><author>Baković, Darija ; Eterović, Davor ; Saratlija-Novaković, XXXana ; Palada, Ivan ; Valic, Zoran ; Bilopavlović, Nada ; Dujić, XXXeljko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4059-a66e7073e6525a1939c1572162b2a5b498c20f86d43cc39d28ffa707f82ab9c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Apnea - blood</topic><topic>Blood Cell Count</topic><topic>Blood Gas Monitoring, Transcutaneous</topic><topic>Blood Pressure</topic><topic>Blood Proteins - metabolism</topic><topic>Carbon Dioxide - blood</topic><topic>Diving</topic><topic>erythrocyte</topic><topic>Female</topic><topic>Heart Rate</topic><topic>Hematocrit</topic><topic>human</topic><topic>Humans</topic><topic>leucocyte</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>plasma volume</topic><topic>platelet</topic><topic>repeated breath-hold</topic><topic>simulated apnoea diving</topic><topic>Spleen - physiology</topic><topic>Splenectomy</topic><topic>splenic contraction</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baković, Darija</creatorcontrib><creatorcontrib>Eterović, Davor</creatorcontrib><creatorcontrib>Saratlija-Novaković, XXXana</creatorcontrib><creatorcontrib>Palada, Ivan</creatorcontrib><creatorcontrib>Valic, Zoran</creatorcontrib><creatorcontrib>Bilopavlović, Nada</creatorcontrib><creatorcontrib>Dujić, XXXeljko</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental pharmacology &amp; physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baković, Darija</au><au>Eterović, Davor</au><au>Saratlija-Novaković, XXXana</au><au>Palada, Ivan</au><au>Valic, Zoran</au><au>Bilopavlović, Nada</au><au>Dujić, XXXeljko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECT OF HUMAN SPLENIC CONTRACTION ON VARIATION IN CIRCULATING BLOOD CELL COUNTS</atitle><jtitle>Clinical and experimental pharmacology &amp; physiology</jtitle><addtitle>Clin Exp Pharmacol Physiol</addtitle><date>2005-11</date><risdate>2005</risdate><volume>32</volume><issue>11</issue><spage>944</spage><epage>951</epage><pages>944-951</pages><issn>0305-1870</issn><eissn>1440-1681</eissn><abstract>SUMMARY 1. The human spleen sequesters 200–250 mL densely packed red blood cells. Up to 50% of this viscous blood is actively expelled into the systemic circulation during strenuous exercise or simulated apnoea (breath‐hold) diving. The contribution of splenic contraction to changes in the circulating volume of red blood cells (RBCV), as well as the venous concentration of white blood cells (WBC) and platelets (PLT), was investigated following repeated breath‐hold apnoeas. 2. Eighteen trained apnoea divers and 18 intact and six splenectomized subjects without diving experience repeated five maximal apnoeas with face immersion in cold water, with 2 min intervals between successive attempts. Venous blood samples were taken before and between consecutive apnoeas, as well as at 0, 10 and 20 min after the last breath hold. Arterial pressure, heart rate and transcutaneous partial pressure of oxygen and carbon dioxide were monitored continuously. 3. Plasma protein concentration decreased by 5.8, 2.2 and 9% in apnoea divers, untrained and splenectomized subjects, respectively, indicating an expansion of plasma volume. The RBCV and venous concentration of WBC, corrected for changes in plasma volume, increased in both trained apnoea divers (4.9 ± 1.0 and 14.9 ± 3.1%, respectively) and intact subjects (1.7 ± 0.8 and 7.2 ± 1.8%, respectively), whereas in splenectomized subjects there was no change in RBCV and a delayed increase in WBC concentration. Furthermore, an initial lymphocytosis detected during repeated breath holds in divers and intact subjects was completely absent in splenectomized subjects. None of the groups showed significant changes in PLT concentrations. The well‐recognized diving response to apnoea (bradycardia and increased blood pressure) was seen during all breath‐hold attempts in all subjects. 4. Repeated breath‐holds (apnoeas) contribute to increased RBCV and venous blood concentrations of WBC through splenic contraction.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Pty</pub><pmid>16405451</pmid><doi>10.1111/j.1440-1681.2005.04289.x</doi><tpages>8</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0305-1870
ispartof Clinical and experimental pharmacology & physiology, 2005-11, Vol.32 (11), p.944-951
issn 0305-1870
1440-1681
language eng
recordid cdi_proquest_miscellaneous_69068571
source MEDLINE; Access via Wiley Online Library
subjects Adult
Apnea - blood
Blood Cell Count
Blood Gas Monitoring, Transcutaneous
Blood Pressure
Blood Proteins - metabolism
Carbon Dioxide - blood
Diving
erythrocyte
Female
Heart Rate
Hematocrit
human
Humans
leucocyte
Leukocyte Count
Male
plasma volume
platelet
repeated breath-hold
simulated apnoea diving
Spleen - physiology
Splenectomy
splenic contraction
Time Factors
title EFFECT OF HUMAN SPLENIC CONTRACTION ON VARIATION IN CIRCULATING BLOOD CELL COUNTS
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T23%3A23%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=EFFECT%20OF%20HUMAN%20SPLENIC%20CONTRACTION%20ON%20VARIATION%20IN%20CIRCULATING%20BLOOD%20CELL%20COUNTS&rft.jtitle=Clinical%20and%20experimental%20pharmacology%20&%20physiology&rft.au=Bakovi%C4%87,%20Darija&rft.date=2005-11&rft.volume=32&rft.issue=11&rft.spage=944&rft.epage=951&rft.pages=944-951&rft.issn=0305-1870&rft.eissn=1440-1681&rft_id=info:doi/10.1111/j.1440-1681.2005.04289.x&rft_dat=%3Cproquest_cross%3E69068571%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69068571&rft_id=info:pmid/16405451&rfr_iscdi=true