Localization of rat Cytochrome P450 in Various Tissues and Comparison of Arachidonic Acid Metabolism by Rat P450 with that by Human P450 Orthologs

Metabolites of arachidonic acid produced by P450 are interesting substances with prominent physiological functions. To elucidate the physiological function of P450, it is necessary to identify a specific P450 in a particular tissue or organ and to characterize its catalytic activities. In this study...

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Veröffentlicht in:	Drug metabolism and pharmacokinetics 2005, Vol.20 (6), p.478-484
Hauptverfasser:	Imaoka, Susumu, Hashizume, Takanori, Funae, Yoshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals arachidonic acid Arachidonic Acid - biosynthesis Arachidonic Acid - genetics Arachidonic Acid - metabolism Baculoviridae - genetics Cell Line Cytochrome P-450 Enzyme System - biosynthesis Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 EET Gene Expression Regulation, Enzymologic HETE Humans Insecta - metabolism Isoenzymes - biosynthesis Isoenzymes - genetics Isoenzymes - metabolism Molecular Sequence Data Rats Reverse Transcriptase Polymerase Chain Reaction RT-PCR Species Specificity Tissue Distribution
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