PHD Domain-Mediated E3 Ligase Activity Directs Intramolecular Sumoylation of an Adjacent Bromodomain Required for Gene Silencing

Tandem PHD and bromodomains are often found in chromatin-associated proteins and have been shown to cooperate in gene silencing. Each domain can bind specifically modified histones: the mechanisms of cooperation between these domains are unknown. We show that the PHD domain of the KAP1 corepressor f...

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Veröffentlicht in:	Molecular cell 2007-12, Vol.28 (5), p.823-837
Hauptverfasser:	Ivanov, Alexey V., Peng, Hongzhuang, Yurchenko, Vyacheslav, Yap, Kyoko L., Negorev, Dmitri G., Schultz, David C., Psulkowski, Elyse, Fredericks, William J., White, David E., Maul, Gerd G., Sadofsky, Moshe J., Zhou, Ming-Ming, Rauscher, Frank J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Autoantigens - genetics Autoantigens - metabolism Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Cells, Cultured Chromatin - metabolism DNA DNA Helicases - genetics DNA Helicases - metabolism DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation Gene Silencing Histone Deacetylases - genetics Histone Deacetylases - metabolism Histone-Lysine N-Methyltransferase Humans Kidney - metabolism Lysine - chemistry Mi-2 Nucleosome Remodeling and Deacetylase Complex Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology Protein Methyltransferases - genetics Protein Methyltransferases - metabolism Protein Processing, Post-Translational PROTEINS Repressor Proteins - antagonists & inhibitors Repressor Proteins - genetics Repressor Proteins - metabolism RING Finger Domains Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - metabolism Small Ubiquitin-Related Modifier Proteins - metabolism Transcription, Genetic Tripartite Motif-Containing Protein 28 Two-Hybrid System Techniques Ubiquitin-Conjugating Enzymes - genetics Ubiquitin-Conjugating Enzymes - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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