Gating Deficits in Model Networks: A Path to Schizophrenia?

Abstract Gating deficits and hallucinatory sensations are prominent symptoms of schizophrenia. Comparing these abnormalities with the failure modes of network models is an interesting way to explore how they arise. We present a network model that can both propagate and gate signals. The model exhibi...

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Veröffentlicht in:	Pharmacopsychiatry 2007-12, Vol.40 (S 1), p.S73-S77
Hauptverfasser:	Vogels, T. P., Abbott, L. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain - physiopathology Humans Models, Neurological Neural Networks (Computer) Original Paper Schizophrenia - physiopathology Schizophrenic Psychology
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description	Abstract Gating deficits and hallucinatory sensations are prominent symptoms of schizophrenia. Comparing these abnormalities with the failure modes of network models is an interesting way to explore how they arise. We present a network model that can both propagate and gate signals. The model exhibits effects reminiscent of clinically observed pathologies when the balance between excitation and inhibition that it requires is not properly maintained.
doi_str_mv	10.1055/s-2007-992130
format	Article
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subjects	Brain - physiopathology Humans Models, Neurological Neural Networks (Computer) Original Paper Schizophrenia - physiopathology Schizophrenic Psychology
title	Gating Deficits in Model Networks: A Path to Schizophrenia?
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