Anti-inflammatory activity of 20(S)-protopanaxadiol: enhanced heme oxygenase 1 expression in RAW 264.7 cells

Abstract 20(S)-Protopanaxadiol (PPD) is one of the metabolites of ginsenosides from PANAX GINSENG. In this study, we demonstrate that PPD inhibits the increase in lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression through inactivation of nuclear factor-κB by preventin...

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Veröffentlicht in:	Planta medica 2005-12, Vol.71 (12), p.1167-1170
Hauptverfasser:	Lee, S.H, Seo, G.S, Ko, G, Kim, J.B, Sohn, D.H
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-inflammatory activity Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Biological and medical sciences Cell Line cultured cells Enzyme Induction - drug effects General pharmacology heme oxygenase 1 Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism Letter Lipopolysaccharides - pharmacology Macrophages - drug effects Macrophages - enzymology Medical sciences mice molecular sequence data Nitric Oxide - metabolism nitric oxide synthase nucleotide sequences oxygenases Panax ginseng Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments protopanaxadiol sapogenins Sapogenins - chemistry Sapogenins - pharmacology Triterpenes - chemistry Triterpenes - pharmacology triterpenoids
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