The ubiquitin ligase ability of IAPs regulates apoptosis

Accumulating evidence indicates that there is a critical role of the ubiquitin/proteasome pathway in the regulation of apoptosis. Among the important molecules that couple these two fundamental cellular activities are members of the inhibitor of apoptosis (IAP) protein family. In addition to their w...

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Veröffentlicht in:	IUBMB life 2005-12, Vol.57 (12), p.779-785
Hauptverfasser:	Ni, Ting, Li, Wenjing, Zou, Fangdong
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - genetics caspase Caspases - metabolism E3 ubiquitin Gene Components IAP Inhibitor of Apoptosis Proteins - genetics Inhibitor of Apoptosis Proteins - metabolism Intracellular Signaling Peptides and Proteins - metabolism Mitochondrial Proteins - metabolism Protein Structure, Tertiary - genetics RING Signal Transduction - genetics Substrate Specificity Ubiquitin-Protein Ligases - metabolism
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