Kinetic Stability Studies on Yttrium(III)−1,4,7,10- Tetraazacyclododecane-1,4,7,10-tetraacetic Acid by Free-Ion Selective Radiotracer Extraction
Free-ion selective radiotracer extraction (FISRE) using no-carrier-added 90Y has been applied to assess the dissociation kinetics of yttrium(III)−1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (Y−DOTA), a radiopharmaceutical precursor with a remarkable kinetic stability. In order to extend...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2007-12, Vol.79 (24), p.9420-9426 |
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| creator | Jurkin, Denis Gildehaus, Franz Josef Wierczinski, Birgit |
| description | Free-ion selective radiotracer extraction (FISRE) using no-carrier-added 90Y has been applied to assess the dissociation kinetics of yttrium(III)−1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (Y−DOTA), a radiopharmaceutical precursor with a remarkable kinetic stability. In order to extend the operationally defined detection window, a complemental FISRE-based experiment has been succesfully developed. Within a time frame of approximately 10 half-times of 90Y (t 1/2 = 61.4 h), the complex Y−DOTA has been observed to form two kinetically distinguishable species with significantly different kinetic properties. The time-dependent speciation was measured to be sensitive to pH variations even in the neutral pH range (4.5−7.4) whereas the impact of ionic strength changes is negligible. |
| doi_str_mv | 10.1021/ac701786w |
| format | Article |
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In order to extend the operationally defined detection window, a complemental FISRE-based experiment has been succesfully developed. Within a time frame of approximately 10 half-times of 90Y (t 1/2 = 61.4 h), the complex Y−DOTA has been observed to form two kinetically distinguishable species with significantly different kinetic properties. 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Chem</addtitle><date>2007-12-15</date><risdate>2007</risdate><volume>79</volume><issue>24</issue><spage>9420</spage><epage>9426</epage><pages>9420-9426</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><abstract>Free-ion selective radiotracer extraction (FISRE) using no-carrier-added 90Y has been applied to assess the dissociation kinetics of yttrium(III)−1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (Y−DOTA), a radiopharmaceutical precursor with a remarkable kinetic stability. In order to extend the operationally defined detection window, a complemental FISRE-based experiment has been succesfully developed. Within a time frame of approximately 10 half-times of 90Y (t 1/2 = 61.4 h), the complex Y−DOTA has been observed to form two kinetically distinguishable species with significantly different kinetic properties. 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| subjects | Analytical chemistry Chemical elements Chemistry Chromatographic methods and physical methods associated with chromatography Drug Stability Exact sciences and technology Half-Life Heterocyclic Compounds - chemistry Hydrogen-Ion Concentration Ions Kinetics Organometallic Compounds - chemistry Other chromatographic methods Radioactive Tracers Radiopharmaceuticals - chemistry Yttrium |
| title | Kinetic Stability Studies on Yttrium(III)−1,4,7,10- Tetraazacyclododecane-1,4,7,10-tetraacetic Acid by Free-Ion Selective Radiotracer Extraction |
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