Fine specificity of the anti–citrullinated protein antibody response is influenced by the shared epitope alleles

Objective In classic studies on the genetic background of antibody production, the major histocompatibility complex (MHC) has been shown to act as the most prominent immune response gene that controls the magnitude and the specificity of antibody production. The strongest genetic risk factor for rhe...

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Veröffentlicht in:	Arthritis and rheumatism 2007-12, Vol.56 (12), p.3949-3952
Hauptverfasser:	Verpoort, K. N., Cheung, K., Ioan‐Facsinay, A., van der Helm‐van Mil, A. H. M., de Vries‐Bouwstra, J. K., Allaart, C. F., Drijfhout, J. W., de Vries, R. R. P., Breedveld, F. C., Huizinga, T. W. J., Pruijn, G. J. M., Toes, R. E. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Antibodies, Anti-Idiotypic - genetics Antibodies, Anti-Idiotypic - immunology Antibodies, Anti-Idiotypic - metabolism Antibody Specificity - genetics Antibody Specificity - immunology Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Biological and medical sciences Citrulline - metabolism Cohort Studies Diseases of the osteoarticular system Epitopes - genetics Fibrinogen - immunology Genetic Predisposition to Disease - genetics HLA-DR Antigens - genetics HLA-DR Antigens - immunology HLA-DRB1 Chains Humans Inflammatory joint diseases Medical sciences Miscellaneous. Osteoarticular involvement in other diseases Vimentin - immunology
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