Induction of Apoptosis by G3139 in Melanoma Cells

G3139 is an 18mer phosphorothioate oligonucleotide targeted to the initiation codon region of the Bcl‐2 mRNA. Because of the ability of this antisense construct to downregulate the expression of Bcl‐2 mRNA and protein, it has entered phase III clinical trials in a number of human cancers, including...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2005-11, Vol.1058 (1), p.235-245
Hauptverfasser:	BENIMETSKAYA, LUBA, LAI, JOHNATHAN C., KHVOROVA, ANASTASIA, WU, SIJIAN, MILLER, PAUL, STEIN, C A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Bcl-2 Caspases - metabolism Cell Survival Clinical Trials as Topic cytochrome c Cytoplasm - metabolism Enzyme Inhibitors - pharmacology G3139 Genasense Humans Melanoma - genetics Melanoma - therapy mitochondria Mitochondria - metabolism Oligonucleotides, Antisense - chemistry Oligonucleotides, Antisense - pharmacology Proto-Oncogene Proteins c-bcl-2 - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Thionucleotides - pharmacology
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