Whole genome deoxyribonucleic acid microarray analysis of gene expression in ectopic versus eutopic endometrium
Objective To use DNA microarrays to identify differentially expressed genes in eutopic endometrium compared with ectopic endometrium. Design Prospective, cross-sectional, observational study. Setting University Medical Center and Research Laboratory. Patient(s) Eleven women with endometriosis. Inter...
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| Veröffentlicht in: | Fertility and sterility 2007-12, Vol.88 (6), p.1505-1533 |
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| creator | Eyster, Kathleen M., Ph.D Klinkova, Olga, M.D Kennedy, Vanessa, B.S Hansen, Keith A., M.D |
| description | Objective To use DNA microarrays to identify differentially expressed genes in eutopic endometrium compared with ectopic endometrium. Design Prospective, cross-sectional, observational study. Setting University Medical Center and Research Laboratory. Patient(s) Eleven women with endometriosis. Intervention(s) None. Main Outcome Measure(s) Differential gene expression. Result(s) Seven hundred seventeen of the 53,000 probes on the whole human DNA microarrays were changed by twofold or greater in ectopic versus eutopic endometrium. Families of genes that were expressed differentially include genes that code for proteins associated with the immune system and inflammatory pathways, cell adhesion, cell-cell junctions, the extracellular matrix and its remodeling, cytoskeletal proteins, and signal transduction pathway components, among others. Conclusion(s) The altered immune environment may allow survival of endometriotic cells that enter the abdominal cavity. Alterations of cell adhesion–associated genes may contribute to the adhesive and invasive properties of ectopic endometrium, and changes in signal transduction pathways support a change in the communication among cells of the endometrial explant compared with eutopic endometrium. These families of differentially expressed genes provide multiple opportunities for the development and testing of new hypotheses regarding endometriosis. |
| doi_str_mv | 10.1016/j.fertnstert.2007.01.056 |
| format | Article |
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Design Prospective, cross-sectional, observational study. Setting University Medical Center and Research Laboratory. Patient(s) Eleven women with endometriosis. Intervention(s) None. Main Outcome Measure(s) Differential gene expression. Result(s) Seven hundred seventeen of the 53,000 probes on the whole human DNA microarrays were changed by twofold or greater in ectopic versus eutopic endometrium. Families of genes that were expressed differentially include genes that code for proteins associated with the immune system and inflammatory pathways, cell adhesion, cell-cell junctions, the extracellular matrix and its remodeling, cytoskeletal proteins, and signal transduction pathway components, among others. Conclusion(s) The altered immune environment may allow survival of endometriotic cells that enter the abdominal cavity. Alterations of cell adhesion–associated genes may contribute to the adhesive and invasive properties of ectopic endometrium, and changes in signal transduction pathways support a change in the communication among cells of the endometrial explant compared with eutopic endometrium. These families of differentially expressed genes provide multiple opportunities for the development and testing of new hypotheses regarding endometriosis.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2007.01.056</identifier><identifier>PMID: 17462640</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Cross-Sectional Studies ; differential gene expression ; DNA - analysis ; DNA microarray ; Endometriosis ; Endometriosis - genetics ; Endometriosis - pathology ; Endometrium - metabolism ; Female ; Female genital diseases ; Gene Expression Profiling ; Genome, Human ; Gynecology. Andrology. Obstetrics ; Humans ; Internal Medicine ; Medical sciences ; Middle Aged ; Non tumoral diseases ; Obstetrics and Gynecology ; Oligonucleotide Array Sequence Analysis ; Peritoneal Diseases - genetics ; Peritoneal Diseases - pathology ; phospholipase A 2 ; Prospective Studies</subject><ispartof>Fertility and sterility, 2007-12, Vol.88 (6), p.1505-1533</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2007 American Society for Reproductive Medicine</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-6bdffad09454368fe9708f8b70d651c64910e402ab6271be9381c8f5f0de522b3</citedby><cites>FETCH-LOGICAL-c573t-6bdffad09454368fe9708f8b70d651c64910e402ab6271be9381c8f5f0de522b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fertnstert.2007.01.056$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19939977$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17462640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eyster, Kathleen M., Ph.D</creatorcontrib><creatorcontrib>Klinkova, Olga, M.D</creatorcontrib><creatorcontrib>Kennedy, Vanessa, B.S</creatorcontrib><creatorcontrib>Hansen, Keith A., M.D</creatorcontrib><title>Whole genome deoxyribonucleic acid microarray analysis of gene expression in ectopic versus eutopic endometrium</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective To use DNA microarrays to identify differentially expressed genes in eutopic endometrium compared with ectopic endometrium. Design Prospective, cross-sectional, observational study. Setting University Medical Center and Research Laboratory. Patient(s) Eleven women with endometriosis. Intervention(s) None. Main Outcome Measure(s) Differential gene expression. Result(s) Seven hundred seventeen of the 53,000 probes on the whole human DNA microarrays were changed by twofold or greater in ectopic versus eutopic endometrium. Families of genes that were expressed differentially include genes that code for proteins associated with the immune system and inflammatory pathways, cell adhesion, cell-cell junctions, the extracellular matrix and its remodeling, cytoskeletal proteins, and signal transduction pathway components, among others. Conclusion(s) The altered immune environment may allow survival of endometriotic cells that enter the abdominal cavity. Alterations of cell adhesion–associated genes may contribute to the adhesive and invasive properties of ectopic endometrium, and changes in signal transduction pathways support a change in the communication among cells of the endometrial explant compared with eutopic endometrium. These families of differentially expressed genes provide multiple opportunities for the development and testing of new hypotheses regarding endometriosis.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cross-Sectional Studies</subject><subject>differential gene expression</subject><subject>DNA - analysis</subject><subject>DNA microarray</subject><subject>Endometriosis</subject><subject>Endometriosis - genetics</subject><subject>Endometriosis - pathology</subject><subject>Endometrium - metabolism</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gene Expression Profiling</subject><subject>Genome, Human</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases</subject><subject>Obstetrics and Gynecology</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Peritoneal Diseases - genetics</subject><subject>Peritoneal Diseases - pathology</subject><subject>phospholipase A 2</subject><subject>Prospective Studies</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks-L1DAUx4so7rj6L0guepv6kjZpexF0WX_AggcVjyFNXzRjm4x57bL9702ZgQFPXhICn-97ySevKBiHkgNXbw6lwzQHmvNaCoCmBF6CVI-KHZdS7aWS1eNiB8DlHkQrropnRAcAULwRT4sr3tRKqBp2RfzxK47IfmKIE7IB48OafB_DYkf0lhnrBzZ5m6JJyazMBDOu5IlFt2WQ4cMxIZGPgfnA0M7xmGP3mGghhsvpiGHI1efkl-l58cSZkfDFeb8uvn-4_XbzaX_35ePnm3d3eyubat6rfnDODNDVsq5U67BroHVt38CgJLeq7jhgDcL0SjS8x65quW2ddDCgFKKvrovXp7rHFP8sSLOePFkcRxMwLqRVl13UXZXB9gTmNxIldPqY_GTSqjnoTbY-6ItsvcnWwHWWnaMvzz2WfsLhEjzbzcCrM2DImtElE6ynC9d1Vdc1TebenzjMRu49Jk3WY7A4-JSV6iH6_7nN23-K2NEHn_v-xhXpEJeUP4801yQ06K_bcGyzAQ2A4BVUfwHvqLps</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>Eyster, Kathleen M., Ph.D</creator><creator>Klinkova, Olga, M.D</creator><creator>Kennedy, Vanessa, B.S</creator><creator>Hansen, Keith A., M.D</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071201</creationdate><title>Whole genome deoxyribonucleic acid microarray analysis of gene expression in ectopic versus eutopic endometrium</title><author>Eyster, Kathleen M., Ph.D ; Klinkova, Olga, M.D ; Kennedy, Vanessa, B.S ; Hansen, Keith A., M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-6bdffad09454368fe9708f8b70d651c64910e402ab6271be9381c8f5f0de522b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cross-Sectional Studies</topic><topic>differential gene expression</topic><topic>DNA - analysis</topic><topic>DNA microarray</topic><topic>Endometriosis</topic><topic>Endometriosis - genetics</topic><topic>Endometriosis - pathology</topic><topic>Endometrium - metabolism</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gene Expression Profiling</topic><topic>Genome, Human</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases</topic><topic>Obstetrics and Gynecology</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Peritoneal Diseases - genetics</topic><topic>Peritoneal Diseases - pathology</topic><topic>phospholipase A 2</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eyster, Kathleen M., Ph.D</creatorcontrib><creatorcontrib>Klinkova, Olga, M.D</creatorcontrib><creatorcontrib>Kennedy, Vanessa, B.S</creatorcontrib><creatorcontrib>Hansen, Keith A., M.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eyster, Kathleen M., Ph.D</au><au>Klinkova, Olga, M.D</au><au>Kennedy, Vanessa, B.S</au><au>Hansen, Keith A., M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Whole genome deoxyribonucleic acid microarray analysis of gene expression in ectopic versus eutopic endometrium</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>88</volume><issue>6</issue><spage>1505</spage><epage>1533</epage><pages>1505-1533</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective To use DNA microarrays to identify differentially expressed genes in eutopic endometrium compared with ectopic endometrium. Design Prospective, cross-sectional, observational study. Setting University Medical Center and Research Laboratory. Patient(s) Eleven women with endometriosis. Intervention(s) None. Main Outcome Measure(s) Differential gene expression. Result(s) Seven hundred seventeen of the 53,000 probes on the whole human DNA microarrays were changed by twofold or greater in ectopic versus eutopic endometrium. Families of genes that were expressed differentially include genes that code for proteins associated with the immune system and inflammatory pathways, cell adhesion, cell-cell junctions, the extracellular matrix and its remodeling, cytoskeletal proteins, and signal transduction pathway components, among others. Conclusion(s) The altered immune environment may allow survival of endometriotic cells that enter the abdominal cavity. Alterations of cell adhesion–associated genes may contribute to the adhesive and invasive properties of ectopic endometrium, and changes in signal transduction pathways support a change in the communication among cells of the endometrial explant compared with eutopic endometrium. These families of differentially expressed genes provide multiple opportunities for the development and testing of new hypotheses regarding endometriosis.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17462640</pmid><doi>10.1016/j.fertnstert.2007.01.056</doi><tpages>29</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Cross-Sectional Studies differential gene expression DNA - analysis DNA microarray Endometriosis Endometriosis - genetics Endometriosis - pathology Endometrium - metabolism Female Female genital diseases Gene Expression Profiling Genome, Human Gynecology. Andrology. Obstetrics Humans Internal Medicine Medical sciences Middle Aged Non tumoral diseases Obstetrics and Gynecology Oligonucleotide Array Sequence Analysis Peritoneal Diseases - genetics Peritoneal Diseases - pathology phospholipase A 2 Prospective Studies |
| title | Whole genome deoxyribonucleic acid microarray analysis of gene expression in ectopic versus eutopic endometrium |
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