Airway epithelial cells in asthma

Epithelial cells in allergic inflammation are reportedly an important source of a wide variety of proinflammatory mediators, including cytokines like IL-6, chemokines like eotaxins (CCL11, CCL24, and CCL26), and monocyte chemotactic proteins (MCPs; MCP-3, MCP-4, CCL7, and CCL13, respectively; Fig 6)...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2007-12, Vol.120 (6), p.1475-1478
Hauptverfasser:	Préfontaine, David, MSc, Hamid, Qutayba, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Apoptosis Asthma Asthma - immunology Asthma - metabolism Asthma - pathology Bronchi - immunology Bronchi - metabolism Bronchi - pathology Chemokines Cytokines Epithelial Cells - immunology Epithelial Cells - metabolism Epithelial Cells - pathology Humans Respiratory Mucosa - immunology Respiratory Mucosa - metabolism Respiratory Mucosa - pathology
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Beschreibung
Zusammenfassung:	Epithelial cells in allergic inflammation are reportedly an important source of a wide variety of proinflammatory mediators, including cytokines like IL-6, chemokines like eotaxins (CCL11, CCL24, and CCL26), and monocyte chemotactic proteins (MCPs; MCP-3, MCP-4, CCL7, and CCL13, respectively; Fig 6),7 growth factors, reactive oxygen or nitrogen species, oxidative arachidonic acid metabolites, vasoactive peptides, and nitric oxide synthase.8 Recent advances regarding epithelial cell activation relate to the recognition of microbe-associated molecular patterns.
ISSN:	0091-6749 1097-6825
DOI:	10.1016/j.jaci.2007.09.041