Late-Life Anemia Is Associated with Increased Risk of Recurrent Falls
Objectives: To examine whether anemia is associated with a higher incidence of recurrent falls. Design: Prospective cohort study. Setting: Community‐dwelling sample in the Netherlands. Participants: Three hundred ninety‐four participants aged 65 to 88 from the Longitudinal Aging Study Amsterdam. mea...
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| Veröffentlicht in: | Journal of the American Geriatrics Society (JAGS) 2005-12, Vol.53 (12), p.2106-2111 |
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| container_title | Journal of the American Geriatrics Society (JAGS) |
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| creator | Penninx, Brenda W. J. H. Pluijm, Saskia M. F. Lips, Paul Woodman, Richard Miedema, Kor Guralnik, Jack M. Deeg, Dorly J. H. |
| description | Objectives: To examine whether anemia is associated with a higher incidence of recurrent falls.
Design: Prospective cohort study.
Setting: Community‐dwelling sample in the Netherlands.
Participants: Three hundred ninety‐four participants aged 65 to 88 from the Longitudinal Aging Study Amsterdam.
measurements: Anemia was defined according to World Health Organization criteria as a hemoglobin concentration less than 12 g/dL in women and less than 13 g/dL in men. Falls were prospectively determined using fall calendars that participants filled out weekly for 3 years. Recurrent fallers were identified as those who fell at least two times within 6 months during the 3‐year follow‐up.
Results: Of the 394 persons, 11.9% (18 women and 29 men) had anemia. The incidence of recurrent falls was 38.3% of anemic persons versus 19.6% of nonanemic persons (P=.004). After adjustment for sex, age, body mass index, and diseases, anemia was significantly associated with a 1.91 times greater risk for recurrent falls (95% confidence interval=1.09–3.36). Poor physical function (indicated by muscle strength, physical performance, and limitations) partly mediated the association between anemia and incidence of recurrent falls.
Conclusion: Late‐life anemia is common and associated with twice the risk of recurrent falls. Muscle weakness and poor physical performance appear to partly mediate this association. |
| doi_str_mv | 10.1111/j.1532-5415.2005.00491.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69060999</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1050983081</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6271-74350a10664ef3c4fe2b15dd10bedd4fd8a509b3c0fac25a794b7aa4a8ca9f263</originalsourceid><addsrcrecordid>eNqNkk9vEzEQxS0EoqHwFdAKCW67jP-vJS5p1YagCFAo4mg5Xls43ey29q6afnucJmolDgRf7NH83tOzZhAqMFQ4n4_rCnNKSs4wrwgArwCYwtX2GZo8Np6jCQCQshaYnaBXKa0BMIG6folOsKCqrhWboIuFGVy5CN4V085tginmqZim1NuQG01xF4bfxbyz0ZmUy2VI10Xvi6WzY4yuG4pL07bpNXrhTZvcm8N9in5eXlydfy4X32bz8-mitIJIXEpGORgMQjDnqWXekRXmTYNh5ZqG-aY2HNSKWvDGEm6kYitpDDO1NcoTQU_Rh73vTexvR5cGvQnJurY1nevHpIUCAUqpoyCXmOcY5ChIIJOSywy--wtc92Ps8m81wUBlzR_c_g1JyvgxSCglcIbqPWRjn1J0Xt_EsDHxXmPQux3Qa70btd6NWu92QD_sgN5m6duD_7jauOZJeBh6Bt4fAJOsaX00nQ3picspRc6RuU977i607v6_A-gvsx_5keXlXh7S4LaPchOvtZBUcv3r60zz72dLdnU200v6B9oL13Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>210369961</pqid></control><display><type>article</type><title>Late-Life Anemia Is Associated with Increased Risk of Recurrent Falls</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Penninx, Brenda W. J. H. ; Pluijm, Saskia M. F. ; Lips, Paul ; Woodman, Richard ; Miedema, Kor ; Guralnik, Jack M. ; Deeg, Dorly J. H.</creator><creatorcontrib>Penninx, Brenda W. J. H. ; Pluijm, Saskia M. F. ; Lips, Paul ; Woodman, Richard ; Miedema, Kor ; Guralnik, Jack M. ; Deeg, Dorly J. H.</creatorcontrib><description>Objectives: To examine whether anemia is associated with a higher incidence of recurrent falls.
Design: Prospective cohort study.
Setting: Community‐dwelling sample in the Netherlands.
Participants: Three hundred ninety‐four participants aged 65 to 88 from the Longitudinal Aging Study Amsterdam.
measurements: Anemia was defined according to World Health Organization criteria as a hemoglobin concentration less than 12 g/dL in women and less than 13 g/dL in men. Falls were prospectively determined using fall calendars that participants filled out weekly for 3 years. Recurrent fallers were identified as those who fell at least two times within 6 months during the 3‐year follow‐up.
Results: Of the 394 persons, 11.9% (18 women and 29 men) had anemia. The incidence of recurrent falls was 38.3% of anemic persons versus 19.6% of nonanemic persons (P=.004). After adjustment for sex, age, body mass index, and diseases, anemia was significantly associated with a 1.91 times greater risk for recurrent falls (95% confidence interval=1.09–3.36). Poor physical function (indicated by muscle strength, physical performance, and limitations) partly mediated the association between anemia and incidence of recurrent falls.
Conclusion: Late‐life anemia is common and associated with twice the risk of recurrent falls. Muscle weakness and poor physical performance appear to partly mediate this association.</description><identifier>ISSN: 0002-8614</identifier><identifier>EISSN: 1532-5415</identifier><identifier>DOI: 10.1111/j.1532-5415.2005.00491.x</identifier><identifier>PMID: 16398894</identifier><identifier>CODEN: JAGSAF</identifier><language>eng</language><publisher>Malden, USA: Blackwell Science Inc</publisher><subject>Accidental Falls - statistics & numerical data ; Adults ; Aged ; Aged, 80 and over ; Anemia ; Anemia - epidemiology ; Anemias. Hemoglobinopathies ; Biological and medical sciences ; Blood disorders ; Comorbidity ; Diseases of red blood cells ; Falls ; Female ; Functioning ; General aspects ; Geriatrics ; Hematologic and hematopoietic diseases ; Humans ; Incidence ; longitudinal study ; Male ; Medical sciences ; muscle strength ; Netherlands - epidemiology ; Older people ; physical function ; Proportional Hazards Models ; Prospective Studies ; Recurrence ; Risk Factors ; Risks ; Strength</subject><ispartof>Journal of the American Geriatrics Society (JAGS), 2005-12, Vol.53 (12), p.2106-2111</ispartof><rights>2006 INIST-CNRS</rights><rights>2005 by the American Geriatrics Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6271-74350a10664ef3c4fe2b15dd10bedd4fd8a509b3c0fac25a794b7aa4a8ca9f263</citedby><cites>FETCH-LOGICAL-c6271-74350a10664ef3c4fe2b15dd10bedd4fd8a509b3c0fac25a794b7aa4a8ca9f263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1532-5415.2005.00491.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1532-5415.2005.00491.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,30977,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17346036$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16398894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Penninx, Brenda W. J. H.</creatorcontrib><creatorcontrib>Pluijm, Saskia M. F.</creatorcontrib><creatorcontrib>Lips, Paul</creatorcontrib><creatorcontrib>Woodman, Richard</creatorcontrib><creatorcontrib>Miedema, Kor</creatorcontrib><creatorcontrib>Guralnik, Jack M.</creatorcontrib><creatorcontrib>Deeg, Dorly J. H.</creatorcontrib><title>Late-Life Anemia Is Associated with Increased Risk of Recurrent Falls</title><title>Journal of the American Geriatrics Society (JAGS)</title><addtitle>J Am Geriatr Soc</addtitle><description>Objectives: To examine whether anemia is associated with a higher incidence of recurrent falls.
Design: Prospective cohort study.
Setting: Community‐dwelling sample in the Netherlands.
Participants: Three hundred ninety‐four participants aged 65 to 88 from the Longitudinal Aging Study Amsterdam.
measurements: Anemia was defined according to World Health Organization criteria as a hemoglobin concentration less than 12 g/dL in women and less than 13 g/dL in men. Falls were prospectively determined using fall calendars that participants filled out weekly for 3 years. Recurrent fallers were identified as those who fell at least two times within 6 months during the 3‐year follow‐up.
Results: Of the 394 persons, 11.9% (18 women and 29 men) had anemia. The incidence of recurrent falls was 38.3% of anemic persons versus 19.6% of nonanemic persons (P=.004). After adjustment for sex, age, body mass index, and diseases, anemia was significantly associated with a 1.91 times greater risk for recurrent falls (95% confidence interval=1.09–3.36). Poor physical function (indicated by muscle strength, physical performance, and limitations) partly mediated the association between anemia and incidence of recurrent falls.
Conclusion: Late‐life anemia is common and associated with twice the risk of recurrent falls. Muscle weakness and poor physical performance appear to partly mediate this association.</description><subject>Accidental Falls - statistics & numerical data</subject><subject>Adults</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anemia</subject><subject>Anemia - epidemiology</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Biological and medical sciences</subject><subject>Blood disorders</subject><subject>Comorbidity</subject><subject>Diseases of red blood cells</subject><subject>Falls</subject><subject>Female</subject><subject>Functioning</subject><subject>General aspects</subject><subject>Geriatrics</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>longitudinal study</subject><subject>Male</subject><subject>Medical sciences</subject><subject>muscle strength</subject><subject>Netherlands - epidemiology</subject><subject>Older people</subject><subject>physical function</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Recurrence</subject><subject>Risk Factors</subject><subject>Risks</subject><subject>Strength</subject><issn>0002-8614</issn><issn>1532-5415</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkk9vEzEQxS0EoqHwFdAKCW67jP-vJS5p1YagCFAo4mg5Xls43ey29q6afnucJmolDgRf7NH83tOzZhAqMFQ4n4_rCnNKSs4wrwgArwCYwtX2GZo8Np6jCQCQshaYnaBXKa0BMIG6folOsKCqrhWboIuFGVy5CN4V085tginmqZim1NuQG01xF4bfxbyz0ZmUy2VI10Xvi6WzY4yuG4pL07bpNXrhTZvcm8N9in5eXlydfy4X32bz8-mitIJIXEpGORgMQjDnqWXekRXmTYNh5ZqG-aY2HNSKWvDGEm6kYitpDDO1NcoTQU_Rh73vTexvR5cGvQnJurY1nevHpIUCAUqpoyCXmOcY5ChIIJOSywy--wtc92Ps8m81wUBlzR_c_g1JyvgxSCglcIbqPWRjn1J0Xt_EsDHxXmPQux3Qa70btd6NWu92QD_sgN5m6duD_7jauOZJeBh6Bt4fAJOsaX00nQ3picspRc6RuU977i607v6_A-gvsx_5keXlXh7S4LaPchOvtZBUcv3r60zz72dLdnU200v6B9oL13Q</recordid><startdate>200512</startdate><enddate>200512</enddate><creator>Penninx, Brenda W. J. H.</creator><creator>Pluijm, Saskia M. F.</creator><creator>Lips, Paul</creator><creator>Woodman, Richard</creator><creator>Miedema, Kor</creator><creator>Guralnik, Jack M.</creator><creator>Deeg, Dorly J. H.</creator><general>Blackwell Science Inc</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7QJ</scope><scope>7X8</scope></search><sort><creationdate>200512</creationdate><title>Late-Life Anemia Is Associated with Increased Risk of Recurrent Falls</title><author>Penninx, Brenda W. J. H. ; Pluijm, Saskia M. F. ; Lips, Paul ; Woodman, Richard ; Miedema, Kor ; Guralnik, Jack M. ; Deeg, Dorly J. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6271-74350a10664ef3c4fe2b15dd10bedd4fd8a509b3c0fac25a794b7aa4a8ca9f263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Accidental Falls - statistics & numerical data</topic><topic>Adults</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anemia</topic><topic>Anemia - epidemiology</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Biological and medical sciences</topic><topic>Blood disorders</topic><topic>Comorbidity</topic><topic>Diseases of red blood cells</topic><topic>Falls</topic><topic>Female</topic><topic>Functioning</topic><topic>General aspects</topic><topic>Geriatrics</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Incidence</topic><topic>longitudinal study</topic><topic>Male</topic><topic>Medical sciences</topic><topic>muscle strength</topic><topic>Netherlands - epidemiology</topic><topic>Older people</topic><topic>physical function</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Recurrence</topic><topic>Risk Factors</topic><topic>Risks</topic><topic>Strength</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Penninx, Brenda W. J. H.</creatorcontrib><creatorcontrib>Pluijm, Saskia M. F.</creatorcontrib><creatorcontrib>Lips, Paul</creatorcontrib><creatorcontrib>Woodman, Richard</creatorcontrib><creatorcontrib>Miedema, Kor</creatorcontrib><creatorcontrib>Guralnik, Jack M.</creatorcontrib><creatorcontrib>Deeg, Dorly J. H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Penninx, Brenda W. J. H.</au><au>Pluijm, Saskia M. F.</au><au>Lips, Paul</au><au>Woodman, Richard</au><au>Miedema, Kor</au><au>Guralnik, Jack M.</au><au>Deeg, Dorly J. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Late-Life Anemia Is Associated with Increased Risk of Recurrent Falls</atitle><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle><addtitle>J Am Geriatr Soc</addtitle><date>2005-12</date><risdate>2005</risdate><volume>53</volume><issue>12</issue><spage>2106</spage><epage>2111</epage><pages>2106-2111</pages><issn>0002-8614</issn><eissn>1532-5415</eissn><coden>JAGSAF</coden><abstract>Objectives: To examine whether anemia is associated with a higher incidence of recurrent falls.
Design: Prospective cohort study.
Setting: Community‐dwelling sample in the Netherlands.
Participants: Three hundred ninety‐four participants aged 65 to 88 from the Longitudinal Aging Study Amsterdam.
measurements: Anemia was defined according to World Health Organization criteria as a hemoglobin concentration less than 12 g/dL in women and less than 13 g/dL in men. Falls were prospectively determined using fall calendars that participants filled out weekly for 3 years. Recurrent fallers were identified as those who fell at least two times within 6 months during the 3‐year follow‐up.
Results: Of the 394 persons, 11.9% (18 women and 29 men) had anemia. The incidence of recurrent falls was 38.3% of anemic persons versus 19.6% of nonanemic persons (P=.004). After adjustment for sex, age, body mass index, and diseases, anemia was significantly associated with a 1.91 times greater risk for recurrent falls (95% confidence interval=1.09–3.36). Poor physical function (indicated by muscle strength, physical performance, and limitations) partly mediated the association between anemia and incidence of recurrent falls.
Conclusion: Late‐life anemia is common and associated with twice the risk of recurrent falls. Muscle weakness and poor physical performance appear to partly mediate this association.</abstract><cop>Malden, USA</cop><pub>Blackwell Science Inc</pub><pmid>16398894</pmid><doi>10.1111/j.1532-5415.2005.00491.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Accidental Falls - statistics & numerical data Adults Aged Aged, 80 and over Anemia Anemia - epidemiology Anemias. Hemoglobinopathies Biological and medical sciences Blood disorders Comorbidity Diseases of red blood cells Falls Female Functioning General aspects Geriatrics Hematologic and hematopoietic diseases Humans Incidence longitudinal study Male Medical sciences muscle strength Netherlands - epidemiology Older people physical function Proportional Hazards Models Prospective Studies Recurrence Risk Factors Risks Strength |
| title | Late-Life Anemia Is Associated with Increased Risk of Recurrent Falls |
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