The effect of coencapsulation of bovine insulin with cyclodextrins in ethylcellulose microcapsules

Polymeric microcapsules have been widely investigated for protein delivery. Common problems include: low stability, low encapsulation efficiency, lack of uniformity, and burst release. Cyclodextrins (CDs) are known to enhance stability and solubility of proteins in solution. This research examines t...

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Veröffentlicht in:	Journal of microencapsulation 2005-09, Vol.22 (6), p.661-670
Hauptverfasser:	Graves, R. L., Makoid, M. C., Jonnalagadda, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences bovine insulin Calorimetry Capsules Cattle Cellulose - chemistry Chemistry, Pharmaceutical Cyclodextrin Cyclodextrins - chemistry Delayed-Action Preparations Drug Carriers Drug Delivery Systems Drug Stability ethylcellulose Excipients - chemistry General pharmacology Hypoglycemic Agents - administration & dosage Insulin - administration & dosage Medical sciences microcapsules Models, Chemical Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments release modelling Temperature
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