Risk factors and consequences of congenital Chagas disease in Yacuiba, south Bolivia
To determine the risk factors of congenital Chagas disease and the consequences of the disease in newborns. Study of 2712 pregnant women and 2742 newborns in Yacuiba, south Bolivia. Chagas infection was determined serologically in mothers and parasitologically in newborns. Consequences of congenital...
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| Veröffentlicht in: | Tropical medicine & international health 2007-12, Vol.12 (12), p.1498-1505 |
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| creator | Salas, N.A Cot, M Schneider, D Mendoza, B Santalla, J.A Postigo, J Chippaux, J.P Brutus, L |
| description | To determine the risk factors of congenital Chagas disease and the consequences of the disease in newborns. Study of 2712 pregnant women and 2742 newborns in Yacuiba, south Bolivia. Chagas infection was determined serologically in mothers and parasitologically in newborns. Consequences of congenital Chagas disease were assessed clinically. The prevalence of Chagas disease in pregnant women was 42.2%. Congenital transmission was estimated at 6% of infected mothers leading to an incidence rate of 2.6% among newborns. Main risk factors of congenital transmission were mothers' seropositivity and maternal Trypanosoma cruzi parasitaemia. Parity was higher in infected than in non-infected mothers, but it was not associated with the risk of congenital transmission. The rate of congenital infection was significantly higher in newborns from multiple pregnancies than in singletons. However, we did not observe statistically significant consequences of Chagas disease in newborns from single pregnancies or among twins. The main risk factors for congenital transmission were infection and parasitaemia of mothers. Consequences of the disease seemed mild in newborns from single pregnancies and perhaps more important in multiple births. |
| doi_str_mv | 10.1111/j.1365-3156.2007.01958.x |
| format | Article |
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Study of 2712 pregnant women and 2742 newborns in Yacuiba, south Bolivia. Chagas infection was determined serologically in mothers and parasitologically in newborns. Consequences of congenital Chagas disease were assessed clinically. The prevalence of Chagas disease in pregnant women was 42.2%. Congenital transmission was estimated at 6% of infected mothers leading to an incidence rate of 2.6% among newborns. Main risk factors of congenital transmission were mothers' seropositivity and maternal Trypanosoma cruzi parasitaemia. Parity was higher in infected than in non-infected mothers, but it was not associated with the risk of congenital transmission. The rate of congenital infection was significantly higher in newborns from multiple pregnancies than in singletons. However, we did not observe statistically significant consequences of Chagas disease in newborns from single pregnancies or among twins. The main risk factors for congenital transmission were infection and parasitaemia of mothers. Consequences of the disease seemed mild in newborns from single pregnancies and perhaps more important in multiple births.</description><identifier>ISSN: 1360-2276</identifier><identifier>EISSN: 1365-3156</identifier><identifier>DOI: 10.1111/j.1365-3156.2007.01958.x</identifier><identifier>PMID: 18076558</identifier><language>eng</language><publisher>Oxford, UK: Oxford, UK : Blackwell Publishing Ltd</publisher><subject>Adult ; Animals ; Biological and medical sciences ; Bolivia ; Bolivia - epidemiology ; Bolivie ; Chagas Disease - congenital ; Chagas Disease - epidemiology ; Chagas Disease - transmission ; congenital Chagas disease ; Congenital diseases ; Disease transmission ; Enfermedad de Chagas congénita ; Female ; femmes enceintes ; General aspects ; Human protozoal diseases ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical - statistics & numerical data ; Infectious diseases ; Logistic Models ; Maladie de Chagas congénitale ; Male ; Medical sciences ; mujeres embarazadas ; neonates ; newborns ; nouveau‐nés ; Parasitic diseases ; Parity ; Pero ; Pregnancy ; Pregnancy Complications, Parasitic - epidemiology ; Pregnancy, Multiple - statistics & numerical data ; pregnant women ; Prevalence ; Protozoal diseases ; recién nacidos ; Risk Factors ; Seroepidemiologic Studies ; transmisión vertical ; transmission verticale ; Trypanosoma cruzi ; Trypanosoma cruzi - isolation & purification ; Trypanosomiasis ; vertical transmission</subject><ispartof>Tropical medicine & international health, 2007-12, Vol.12 (12), p.1498-1505</ispartof><rights>2008 INIST-CNRS</rights><rights>2007 Blackwell Publishing Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4798-92cb9bc320d77d77b90f9b7ec6b59f550b269d19a89336971b1780ec0c3468f03</citedby><cites>FETCH-LOGICAL-c4798-92cb9bc320d77d77b90f9b7ec6b59f550b269d19a89336971b1780ec0c3468f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-3156.2007.01958.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-3156.2007.01958.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19907254$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18076558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salas, N.A</creatorcontrib><creatorcontrib>Cot, M</creatorcontrib><creatorcontrib>Schneider, D</creatorcontrib><creatorcontrib>Mendoza, B</creatorcontrib><creatorcontrib>Santalla, J.A</creatorcontrib><creatorcontrib>Postigo, J</creatorcontrib><creatorcontrib>Chippaux, J.P</creatorcontrib><creatorcontrib>Brutus, L</creatorcontrib><title>Risk factors and consequences of congenital Chagas disease in Yacuiba, south Bolivia</title><title>Tropical medicine & international health</title><addtitle>Trop Med Int Health</addtitle><description>To determine the risk factors of congenital Chagas disease and the consequences of the disease in newborns. Study of 2712 pregnant women and 2742 newborns in Yacuiba, south Bolivia. Chagas infection was determined serologically in mothers and parasitologically in newborns. Consequences of congenital Chagas disease were assessed clinically. The prevalence of Chagas disease in pregnant women was 42.2%. Congenital transmission was estimated at 6% of infected mothers leading to an incidence rate of 2.6% among newborns. Main risk factors of congenital transmission were mothers' seropositivity and maternal Trypanosoma cruzi parasitaemia. Parity was higher in infected than in non-infected mothers, but it was not associated with the risk of congenital transmission. The rate of congenital infection was significantly higher in newborns from multiple pregnancies than in singletons. However, we did not observe statistically significant consequences of Chagas disease in newborns from single pregnancies or among twins. The main risk factors for congenital transmission were infection and parasitaemia of mothers. Consequences of the disease seemed mild in newborns from single pregnancies and perhaps more important in multiple births.</description><subject>Adult</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bolivia</subject><subject>Bolivia - epidemiology</subject><subject>Bolivie</subject><subject>Chagas Disease - congenital</subject><subject>Chagas Disease - epidemiology</subject><subject>Chagas Disease - transmission</subject><subject>congenital Chagas disease</subject><subject>Congenital diseases</subject><subject>Disease transmission</subject><subject>Enfermedad de Chagas congénita</subject><subject>Female</subject><subject>femmes enceintes</subject><subject>General aspects</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infectious Disease Transmission, Vertical - statistics & numerical data</subject><subject>Infectious diseases</subject><subject>Logistic Models</subject><subject>Maladie de Chagas congénitale</subject><subject>Male</subject><subject>Medical sciences</subject><subject>mujeres embarazadas</subject><subject>neonates</subject><subject>newborns</subject><subject>nouveau‐nés</subject><subject>Parasitic diseases</subject><subject>Parity</subject><subject>Pero</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Parasitic - epidemiology</subject><subject>Pregnancy, Multiple - statistics & numerical data</subject><subject>pregnant women</subject><subject>Prevalence</subject><subject>Protozoal diseases</subject><subject>recién nacidos</subject><subject>Risk Factors</subject><subject>Seroepidemiologic Studies</subject><subject>transmisión vertical</subject><subject>transmission verticale</subject><subject>Trypanosoma cruzi</subject><subject>Trypanosoma cruzi - isolation & purification</subject><subject>Trypanosomiasis</subject><subject>vertical transmission</subject><issn>1360-2276</issn><issn>1365-3156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAUhS0EomXgL4CFRFckXL_tRRcw4lGpCAmmC1aW4zhTD5m4xJPS_nuczohKbMCy5Wv5O9fHOghhAjUp482mJkyKihEhawqgaiBG6PrmATr-c_HwroaKUiWP0JOcNwDAuZCP0RHRoKQQ-hitvsb8A3fO79KYsRta7NOQw88pDD5knLr5vA5D3LkeLy_d2mXcxhxcDjgO-LvzU2zca5zTtLvE71Ifr6N7ih51rs_h2WFfoIsP71fLT9X5l49ny7fnlefK6MpQ35jGMwqtUmU2BjrTqOBlI0wnBDRUmpYYpw1j0ijSEKUhePCMS90BW6CTfd-rMRXHeWe3MfvQ924IacpWGhCagfknSIFrpstaoJd_gZs0jUP5hKWkOBKcqALpPeTHlPMYOns1xq0bby0BO-djN3aOwc4x2Dkfe5ePvSnS54f-U7MN7b3wEEgBXh0Al73ru9ENPuZ7zhhQVPDCne65X7EPt_9twK4-n81V0b_Y6zuXrFuP5Y2LbxQIA9CMMc7Zb36jspA</recordid><startdate>200712</startdate><enddate>200712</enddate><creator>Salas, N.A</creator><creator>Cot, M</creator><creator>Schneider, D</creator><creator>Mendoza, B</creator><creator>Santalla, J.A</creator><creator>Postigo, J</creator><creator>Chippaux, J.P</creator><creator>Brutus, L</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><general>Blackwell Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>200712</creationdate><title>Risk factors and consequences of congenital Chagas disease in Yacuiba, south Bolivia</title><author>Salas, N.A ; Cot, M ; Schneider, D ; Mendoza, B ; Santalla, J.A ; Postigo, J ; Chippaux, J.P ; Brutus, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4798-92cb9bc320d77d77b90f9b7ec6b59f550b269d19a89336971b1780ec0c3468f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bolivia</topic><topic>Bolivia - epidemiology</topic><topic>Bolivie</topic><topic>Chagas Disease - congenital</topic><topic>Chagas Disease - epidemiology</topic><topic>Chagas Disease - transmission</topic><topic>congenital Chagas disease</topic><topic>Congenital diseases</topic><topic>Disease transmission</topic><topic>Enfermedad de Chagas congénita</topic><topic>Female</topic><topic>femmes enceintes</topic><topic>General aspects</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infectious Disease Transmission, Vertical - statistics & numerical data</topic><topic>Infectious diseases</topic><topic>Logistic Models</topic><topic>Maladie de Chagas congénitale</topic><topic>Male</topic><topic>Medical sciences</topic><topic>mujeres embarazadas</topic><topic>neonates</topic><topic>newborns</topic><topic>nouveau‐nés</topic><topic>Parasitic diseases</topic><topic>Parity</topic><topic>Pero</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Parasitic - epidemiology</topic><topic>Pregnancy, Multiple - statistics & numerical data</topic><topic>pregnant women</topic><topic>Prevalence</topic><topic>Protozoal diseases</topic><topic>recién nacidos</topic><topic>Risk Factors</topic><topic>Seroepidemiologic Studies</topic><topic>transmisión vertical</topic><topic>transmission verticale</topic><topic>Trypanosoma cruzi</topic><topic>Trypanosoma cruzi - isolation & purification</topic><topic>Trypanosomiasis</topic><topic>vertical transmission</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salas, N.A</creatorcontrib><creatorcontrib>Cot, M</creatorcontrib><creatorcontrib>Schneider, D</creatorcontrib><creatorcontrib>Mendoza, B</creatorcontrib><creatorcontrib>Santalla, J.A</creatorcontrib><creatorcontrib>Postigo, J</creatorcontrib><creatorcontrib>Chippaux, J.P</creatorcontrib><creatorcontrib>Brutus, L</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Tropical medicine & international health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salas, N.A</au><au>Cot, M</au><au>Schneider, D</au><au>Mendoza, B</au><au>Santalla, J.A</au><au>Postigo, J</au><au>Chippaux, J.P</au><au>Brutus, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors and consequences of congenital Chagas disease in Yacuiba, south Bolivia</atitle><jtitle>Tropical medicine & international health</jtitle><addtitle>Trop Med Int Health</addtitle><date>2007-12</date><risdate>2007</risdate><volume>12</volume><issue>12</issue><spage>1498</spage><epage>1505</epage><pages>1498-1505</pages><issn>1360-2276</issn><eissn>1365-3156</eissn><abstract>To determine the risk factors of congenital Chagas disease and the consequences of the disease in newborns. Study of 2712 pregnant women and 2742 newborns in Yacuiba, south Bolivia. Chagas infection was determined serologically in mothers and parasitologically in newborns. Consequences of congenital Chagas disease were assessed clinically. The prevalence of Chagas disease in pregnant women was 42.2%. Congenital transmission was estimated at 6% of infected mothers leading to an incidence rate of 2.6% among newborns. Main risk factors of congenital transmission were mothers' seropositivity and maternal Trypanosoma cruzi parasitaemia. Parity was higher in infected than in non-infected mothers, but it was not associated with the risk of congenital transmission. The rate of congenital infection was significantly higher in newborns from multiple pregnancies than in singletons. However, we did not observe statistically significant consequences of Chagas disease in newborns from single pregnancies or among twins. The main risk factors for congenital transmission were infection and parasitaemia of mothers. Consequences of the disease seemed mild in newborns from single pregnancies and perhaps more important in multiple births.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>18076558</pmid><doi>10.1111/j.1365-3156.2007.01958.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Animals Biological and medical sciences Bolivia Bolivia - epidemiology Bolivie Chagas Disease - congenital Chagas Disease - epidemiology Chagas Disease - transmission congenital Chagas disease Congenital diseases Disease transmission Enfermedad de Chagas congénita Female femmes enceintes General aspects Human protozoal diseases Humans Infant, Newborn Infectious Disease Transmission, Vertical - statistics & numerical data Infectious diseases Logistic Models Maladie de Chagas congénitale Male Medical sciences mujeres embarazadas neonates newborns nouveau‐nés Parasitic diseases Parity Pero Pregnancy Pregnancy Complications, Parasitic - epidemiology Pregnancy, Multiple - statistics & numerical data pregnant women Prevalence Protozoal diseases recién nacidos Risk Factors Seroepidemiologic Studies transmisión vertical transmission verticale Trypanosoma cruzi Trypanosoma cruzi - isolation & purification Trypanosomiasis vertical transmission |
| title | Risk factors and consequences of congenital Chagas disease in Yacuiba, south Bolivia |
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