Adenovirus-mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via upregulation of the expression of endogenous vascular endothelial growth factor-A

Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family that binds specifically to VEGF receptor (VEGFR)-1. However, the mechanism of PlGF- and VEGFR-1-mediated angiogenesis has remained unclear and some in vitro studies suggest that VEGF-A/VEGFR-2 signalin...

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Veröffentlicht in:	Human gene therapy 2005-12, Vol.16 (12), p.1422-1428
Hauptverfasser:	ROY, Himadri, BHARDWAJ, Shalini, BABU, Mohan, JAUHIAINEN, Suvi, HERZIG, Karl-Heinz, BELLU, Anna R, HAISMA, Hidde J, CARMELIET, Peter, ALITALO, Kari, YLÄ-HERTTUALA, Seppo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Angiogenesis Inducing Agents Animals Applied cell therapy and gene therapy Biological and medical sciences Biotechnology Cell differentiation, maturation, development, hematopoiesis Cell physiology Fundamental and applied biological sciences. Psychology Gene Expression Regulation Gene therapy Gene Transfer Techniques Genetic Vectors Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Lac Operon Male Medical sciences Molecular and cellular biology Neovascularization, Physiologic - genetics Neovascularization, Physiologic - physiology Placenta Growth Factor Pregnancy Proteins - genetics Rabbits RNA, Messenger - biosynthesis RNA, Messenger - genetics Signal Transduction Transfusions. Complications. Transfusion reactions. Cell and gene therapy Up-Regulation Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor Receptor-1 - genetics Vascular Endothelial Growth Factor Receptor-1 - metabolism Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - metabolism
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