Biological effects of acute pravastatin treatment in patients after aneurysmal subarachnoid hemorrhage : a double-blind, placebo-controlled trial

The authors previously demonstrated that acute pravastatin therapy in patients after aneurysmal subarachnoid hemorrhage (SAH) ameliorates vasospasm-related delayed ischemic neurological deficits. The object of this study was to continue to examine potential mechanisms of these beneficial effects. Ei...

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Veröffentlicht in:	Journal of neurosurgery 2007-12, Vol.107 (6), p.1092-1100
Hauptverfasser:	TSENG, Ming-Yuan, HUTCHINSON, Peter J, TURNER, Carole L, CZOSNYKA, Marek, RICHARDS, Hugh, PICKARD, John D, KIRKPATRICK, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Aged Aged, 80 and over Biological and medical sciences Brain Ischemia - etiology Brain Ischemia - prevention & control C-Reactive Protein - metabolism Cholesterol, LDL - blood Double-Blind Method Fibrin Fibrinogen Degradation Products - metabolism Fibrinogen - metabolism Hematocrit Hemoglobins - metabolism Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Intracranial Aneurysm - complications Leukocyte Count Lipids - blood Logistic Models Medical sciences Middle Aged Neurosurgery Platelet Count Pravastatin - administration & dosage Pravastatin - therapeutic use Risk Factors Subarachnoid Hemorrhage - blood Subarachnoid Hemorrhage - complications Subarachnoid Hemorrhage - drug therapy Subarachnoid Hemorrhage - etiology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Vasospasm, Intracranial - complications Vasospasm, Intracranial - etiology
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