Psychopathology in Verified Huntington's Disease Gene Carriers
Huntington's disease is characterized by motor, cognitive, and neuropsychiatric symptoms. This study reviews original research on psychopathology in Huntington's disease that uses standardized instruments in verified gene carriers. Frequently reported neuropsychiatric symptoms are depresse...
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| Veröffentlicht in: | The journal of neuropsychiatry and clinical neurosciences 2007-10, Vol.19 (4), p.441-448 |
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| container_issue | 4 |
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| container_title | The journal of neuropsychiatry and clinical neurosciences |
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| creator | van Duijn, E Kingma, E.M van der Mast, R.C |
| description | Huntington's disease is characterized by motor, cognitive, and neuropsychiatric symptoms. This study reviews original research on psychopathology in Huntington's disease that uses standardized instruments in verified gene carriers. Frequently reported neuropsychiatric symptoms are depressed mood, anxiety, irritability, and apathy, with prevalences of 33% to 76%. Obsessive-compulsive symptoms and psychosis occur less often with prevalences of 10% to 52% and 3% to 11%, respectively. Available research provides little insight into the true prevalences of psychopathology in Huntington's disease due to small sample sizes, use of different methodologies, and lack of comparison groups. Future research requires larger cohorts stratified to disease stage, consistent methodologies, and adequate comparison groups. |
| doi_str_mv | 10.1176/jnp.2007.19.4.441 |
| format | Article |
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This study reviews original research on psychopathology in Huntington's disease that uses standardized instruments in verified gene carriers. Frequently reported neuropsychiatric symptoms are depressed mood, anxiety, irritability, and apathy, with prevalences of 33% to 76%. Obsessive-compulsive symptoms and psychosis occur less often with prevalences of 10% to 52% and 3% to 11%, respectively. Available research provides little insight into the true prevalences of psychopathology in Huntington's disease due to small sample sizes, use of different methodologies, and lack of comparison groups. Future research requires larger cohorts stratified to disease stage, consistent methodologies, and adequate comparison groups.</description><identifier>ISSN: 0895-0172</identifier><identifier>EISSN: 1545-7222</identifier><identifier>DOI: 10.1176/jnp.2007.19.4.441</identifier><identifier>PMID: 18070848</identifier><identifier>CODEN: JNCNE7</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing, Inc</publisher><subject>Adult and adolescent clinical studies ; Anxiety - epidemiology ; Anxiety - etiology ; Anxiety - psychology ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Depression - epidemiology ; Depression - etiology ; Depression - psychology ; DNA Repeat Expansion - genetics ; Heterozygote ; Humans ; Huntington Disease - epidemiology ; Huntington Disease - genetics ; Huntington Disease - psychology ; Irritable Mood - physiology ; Medical sciences ; Mental Disorders - epidemiology ; Mental Disorders - genetics ; Mental Disorders - psychology ; Nervous system (semeiology, syndromes) ; Nervous system as a whole ; Neurology ; Neuropsychological Tests ; Obsessive-Compulsive Disorder - epidemiology ; Obsessive-Compulsive Disorder - etiology ; Obsessive-Compulsive Disorder - psychology ; Organic mental disorders. Neuropsychology ; Psychiatric Status Rating Scales ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychotic Disorders - epidemiology ; Psychotic Disorders - etiology ; Psychotic Disorders - psychology ; Reproducibility of Results</subject><ispartof>The journal of neuropsychiatry and clinical neurosciences, 2007-10, Vol.19 (4), p.441-448</ispartof><rights>2008 INIST-CNRS</rights><rights>Copyright American Psychiatric Publishing, Inc. Fall 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a310t-ff689cfbc457ecf710679ef6e5614071947b1ae009a09f6f4c893971e2940e83</citedby><cites>FETCH-LOGICAL-a310t-ff689cfbc457ecf710679ef6e5614071947b1ae009a09f6f4c893971e2940e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/jnp.2007.19.4.441$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/jnp.2007.19.4.441$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,776,780,2842,21605,21606,21607,27901,27902,77536,77541</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19881385$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18070848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Duijn, E</creatorcontrib><creatorcontrib>Kingma, E.M</creatorcontrib><creatorcontrib>van der Mast, R.C</creatorcontrib><title>Psychopathology in Verified Huntington's Disease Gene Carriers</title><title>The journal of neuropsychiatry and clinical neurosciences</title><addtitle>J Neuropsychiatry Clin Neurosci</addtitle><description>Huntington's disease is characterized by motor, cognitive, and neuropsychiatric symptoms. This study reviews original research on psychopathology in Huntington's disease that uses standardized instruments in verified gene carriers. Frequently reported neuropsychiatric symptoms are depressed mood, anxiety, irritability, and apathy, with prevalences of 33% to 76%. Obsessive-compulsive symptoms and psychosis occur less often with prevalences of 10% to 52% and 3% to 11%, respectively. Available research provides little insight into the true prevalences of psychopathology in Huntington's disease due to small sample sizes, use of different methodologies, and lack of comparison groups. Future research requires larger cohorts stratified to disease stage, consistent methodologies, and adequate comparison groups.</description><subject>Adult and adolescent clinical studies</subject><subject>Anxiety - epidemiology</subject><subject>Anxiety - etiology</subject><subject>Anxiety - psychology</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Depression - epidemiology</subject><subject>Depression - etiology</subject><subject>Depression - psychology</subject><subject>DNA Repeat Expansion - genetics</subject><subject>Heterozygote</subject><subject>Humans</subject><subject>Huntington Disease - epidemiology</subject><subject>Huntington Disease - genetics</subject><subject>Huntington Disease - psychology</subject><subject>Irritable Mood - physiology</subject><subject>Medical sciences</subject><subject>Mental Disorders - epidemiology</subject><subject>Mental Disorders - genetics</subject><subject>Mental Disorders - psychology</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Nervous system as a whole</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Obsessive-Compulsive Disorder - epidemiology</subject><subject>Obsessive-Compulsive Disorder - etiology</subject><subject>Obsessive-Compulsive Disorder - psychology</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychotic Disorders - epidemiology</subject><subject>Psychotic Disorders - etiology</subject><subject>Psychotic Disorders - psychology</subject><subject>Reproducibility of Results</subject><issn>0895-0172</issn><issn>1545-7222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1rFEEURQsxmDH6A9xII0RX3b5XXV0fG0FGTYSALoLboqbyKqmhp7qt6l7Mv08PMxARsnqbc--7HMbeITSISn7eprHhAKpB04hGCHzBVtiJrlac85dsBdp0NaDi5-x1KVsA4K0Ur9g5alCghV6xL7_L3j8Mo5sehn6431cxVX8oxxDprrqe0xTT_TSkT6X6Fgu5QtUVJarWLudIubxhZ8H1hd6e7gW7_fH9dn1d3_y6-rn-elO7FmGqQ5Da-LDxolPkg0KQylCQ1EkUoNAItUFHAMaBCTIIr01rFBI3Aki3F-zjsXbMw9-ZymR3sXjqe5domIuVBjrF8QB--A_cDnNOyzSLpuNcS9UuEB4hn4dSMgU75rhzeW8R7EGsXcTag9glZIVdxC6Z96fiebOju6fEyeQCXJ4AV7zrQ3bJx_LEGa2x1d3CNUfOjWP8Z92znx8Bg_yORg</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>van Duijn, E</creator><creator>Kingma, E.M</creator><creator>van der Mast, R.C</creator><general>American Psychiatric Publishing, Inc</general><general>American Psychiatric Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>Psychopathology in Verified Huntington's Disease Gene Carriers</title><author>van Duijn, E ; Kingma, E.M ; van der Mast, R.C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a310t-ff689cfbc457ecf710679ef6e5614071947b1ae009a09f6f4c893971e2940e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Anxiety - epidemiology</topic><topic>Anxiety - etiology</topic><topic>Anxiety - psychology</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Depression - epidemiology</topic><topic>Depression - etiology</topic><topic>Depression - psychology</topic><topic>DNA Repeat Expansion - genetics</topic><topic>Heterozygote</topic><topic>Humans</topic><topic>Huntington Disease - epidemiology</topic><topic>Huntington Disease - genetics</topic><topic>Huntington Disease - psychology</topic><topic>Irritable Mood - physiology</topic><topic>Medical sciences</topic><topic>Mental Disorders - epidemiology</topic><topic>Mental Disorders - genetics</topic><topic>Mental Disorders - psychology</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Nervous system as a whole</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Obsessive-Compulsive Disorder - epidemiology</topic><topic>Obsessive-Compulsive Disorder - etiology</topic><topic>Obsessive-Compulsive Disorder - psychology</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychotic Disorders - epidemiology</topic><topic>Psychotic Disorders - etiology</topic><topic>Psychotic Disorders - psychology</topic><topic>Reproducibility of Results</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Duijn, E</creatorcontrib><creatorcontrib>Kingma, E.M</creatorcontrib><creatorcontrib>van der Mast, R.C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of neuropsychiatry and clinical neurosciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Duijn, E</au><au>Kingma, E.M</au><au>van der Mast, R.C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Psychopathology in Verified Huntington's Disease Gene Carriers</atitle><jtitle>The journal of neuropsychiatry and clinical neurosciences</jtitle><addtitle>J Neuropsychiatry Clin Neurosci</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>19</volume><issue>4</issue><spage>441</spage><epage>448</epage><pages>441-448</pages><issn>0895-0172</issn><eissn>1545-7222</eissn><coden>JNCNE7</coden><abstract>Huntington's disease is characterized by motor, cognitive, and neuropsychiatric symptoms. This study reviews original research on psychopathology in Huntington's disease that uses standardized instruments in verified gene carriers. Frequently reported neuropsychiatric symptoms are depressed mood, anxiety, irritability, and apathy, with prevalences of 33% to 76%. Obsessive-compulsive symptoms and psychosis occur less often with prevalences of 10% to 52% and 3% to 11%, respectively. Available research provides little insight into the true prevalences of psychopathology in Huntington's disease due to small sample sizes, use of different methodologies, and lack of comparison groups. Future research requires larger cohorts stratified to disease stage, consistent methodologies, and adequate comparison groups.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing, Inc</pub><pmid>18070848</pmid><doi>10.1176/jnp.2007.19.4.441</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; American Psychiatric Publishing Journals (1997-Present); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult and adolescent clinical studies Anxiety - epidemiology Anxiety - etiology Anxiety - psychology Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Depression - epidemiology Depression - etiology Depression - psychology DNA Repeat Expansion - genetics Heterozygote Humans Huntington Disease - epidemiology Huntington Disease - genetics Huntington Disease - psychology Irritable Mood - physiology Medical sciences Mental Disorders - epidemiology Mental Disorders - genetics Mental Disorders - psychology Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Neuropsychological Tests Obsessive-Compulsive Disorder - epidemiology Obsessive-Compulsive Disorder - etiology Obsessive-Compulsive Disorder - psychology Organic mental disorders. Neuropsychology Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychotic Disorders - epidemiology Psychotic Disorders - etiology Psychotic Disorders - psychology Reproducibility of Results |
| title | Psychopathology in Verified Huntington's Disease Gene Carriers |
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