Ectodomain shedding of pro-TGF-alpha is required for COX-2 induction and cell survival in renal medullary cells exposed to osmotic stress

In the renal medulla, cyclooxygenase (COX)-2 is induced by osmotic stress as present in this kidney region during antidiuresis. Increasing evidence suggests that EGF receptor (EGFR) signaling is involved in this process. The aim of the present study was to examine the mechanisms responsible for COX-...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2007-12, Vol.293 (6), p.C1971-C1982
Hauptverfasser:	Küper, Christoph, Bartels, Helmut, Fraek, Maria-Luisa, Beck, Franz X, Neuhofer, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - metabolism ADAM17 Protein Animals Autocrine Communication - physiology Cell Line Cell Survival Cyclooxygenase 2 - metabolism Dinoprostone - biosynthesis Dogs Gene Expression Regulation Group IV Phospholipases A2 - metabolism Hypertonic Solutions Kidney Medulla - metabolism Ligands Mitogen-Activated Protein Kinases - metabolism Osmotic Pressure Paracrine Communication - physiology Phosphorylation Protein Structure, Tertiary Reactive Oxygen Species - metabolism Receptor, Epidermal Growth Factor - metabolism Transforming Growth Factor alpha - metabolism
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