Targeted cancer therapies based on the inhibition of DNA strand break repair

Both DNA double- and single-strand break repair are highly coordinated processes utilizing signal transduction cascades and post-translational modifications such as phosphorylation, acetylation and ADP ribosylation. ‘Drugable’ targets within these networks have been identified that could potentially...

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Veröffentlicht in:	Oncogene 2007-12, Vol.26 (56), p.7816-7824
Hauptverfasser:	O'Connor, M J, Martin, N M B, Smith, G C M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Active sites Adenine Antineoplastic Agents - pharmacology Apoptosis Ataxia Biomedical research Cancer Cancer therapies Care and treatment Cell Biology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Chemosensitization CHK1 protein CHK2 protein Clinical trials Deoxyribonucleic acid DNA DNA Damage DNA Repair DNA-dependent protein kinase Drug discovery Enzyme Inhibitors - pharmacology Genetic aspects Genetics Human Genetics Humans Internal Medicine Kinases Lethality Medicine Medicine & Public Health NAD Neoplasms - drug therapy Neoplasms - genetics Oncology Phosphorylation Poly(ADP-ribose) Poly(ADP-ribose) polymerase Post-translation Radiation-Sensitizing Agents - therapeutic use review Ribose Ribosylation Signal Transduction Targeted cancer therapy
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