The malignant clone and the bone-marrow environment

Multiple myeloma (MM) is characterized by the clonal expansion of monoclonal immunoglobulin-secreting plasma cells within the bone marrow (BM). It has become clear that the intimate reciprocal relationship between the tumor cell clone and the niches of the BM microenvironment plays a pivotal pathoph...

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Veröffentlicht in:	Best practice & research. Clinical haematology 2007-12, Vol.20 (4), p.597-612
Hauptverfasser:	Podar, Klaus, MD, PhD, Richardson, Paul G., MD, Hideshima, Teru, MD, PhD, Chauhan, Dharminder, PhD, JD, Anderson, Kenneth C., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Bone Marrow - physiology Bone Marrow Cells - pathology bone-marrow microenvironment bone-marrow niches Cell Communication - physiology Cell Death Cell Survival Clone Cells Epigenesis, Genetic - physiology epigenesist extracellular matrix Extracellular Matrix - physiology Hematology, Oncology and Palliative Medicine Humans Intercellular Signaling Peptides and Proteins - physiology multiple myeloma Multiple Myeloma - genetics Multiple Myeloma - physiopathology mutations telomeres translocations
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