Synthesis and characterization of novel internal surface reversed-phase silica supports for high-performance liquid chromatography
An original synthetic method was developed for the preparation of a family of six novel deactivated restricted-access materials (RAMs), belonging to the group of the internal surface reversed-phase (ISRP) supports. The supports (ISRP-RAM phases A–F) have an alkyl-chain (14 methylenes) with two embed...
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| Veröffentlicht in: | Journal of Chromatography A 2007-12, Vol.1176 (1), p.79-88 |
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| container_title | Journal of Chromatography A |
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| creator | Gasparrini, Francesco Ciogli, Alessia D’Acquarica, Ilaria Misiti, Domenico Badaloni, Elena Giorgi, Fabrizio Vigevani, Aristide |
| description | An original synthetic method was developed for the preparation of a family of six novel deactivated restricted-access materials (RAMs), belonging to the group of the internal surface reversed-phase (ISRP) supports. The supports (ISRP-RAM phases A–F) have an alkyl-chain (14 methylenes) with two embedded ureido groups bound only to the internal surfaces of the porous silica, and polyvinyl alcoholic groups (PVA, 100
000
→
22
000 molecular weight) chemically bound to the external surfaces. The average pore diameters of the prepared ISRP-RAM supports, calculated by inverse size-exclusion chromatography, ranged between 49
Å and 88
Å, and were able to exclude macromolecules heavier than about 24
000
Da (such as serum proteins) from the pores. The novel supports were designed for the determination of a semi-synthetic anticancer drug of the camptothecin family in human plasma, but they represent universal ISRP-RAM supports not limited to such class of compounds. |
| doi_str_mv | 10.1016/j.chroma.2007.10.062 |
| format | Article |
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000
→
22
000 molecular weight) chemically bound to the external surfaces. The average pore diameters of the prepared ISRP-RAM supports, calculated by inverse size-exclusion chromatography, ranged between 49
Å and 88
Å, and were able to exclude macromolecules heavier than about 24
000
Da (such as serum proteins) from the pores. The novel supports were designed for the determination of a semi-synthetic anticancer drug of the camptothecin family in human plasma, but they represent universal ISRP-RAM supports not limited to such class of compounds.</description><identifier>ISSN: 0021-9673</identifier><identifier>DOI: 10.1016/j.chroma.2007.10.062</identifier><identifier>PMID: 18022629</identifier><identifier>CODEN: JOCRAM</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Analytical chemistry ; Biological and medical sciences ; Chemistry ; Chromatographic methods and physical methods associated with chromatography ; Chromatography, High Pressure Liquid - instrumentation ; Exact sciences and technology ; Exclusion pore size ( Φe) ; General pharmacology ; Gimatecan ; Hydrophilic network ; Internal surface reversed-phase (ISRP) supports ; Medical sciences ; Other chromatographic methods ; Pharmacology. Drug treatments ; Pore size distribution (PSD) ; Restricted-access materials (RAMs) ; Silicon Dioxide - chemistry ; Surface Properties</subject><ispartof>Journal of Chromatography A, 2007-12, Vol.1176 (1), p.79-88</ispartof><rights>2007 Elsevier B.V.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-f49639e0b4b17b94acc700f3a7ac7bb95c79016fec959e119080dc79f2b933b3</citedby><cites>FETCH-LOGICAL-c390t-f49639e0b4b17b94acc700f3a7ac7bb95c79016fec959e119080dc79f2b933b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.chroma.2007.10.062$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19886770$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18022629$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gasparrini, Francesco</creatorcontrib><creatorcontrib>Ciogli, Alessia</creatorcontrib><creatorcontrib>D’Acquarica, Ilaria</creatorcontrib><creatorcontrib>Misiti, Domenico</creatorcontrib><creatorcontrib>Badaloni, Elena</creatorcontrib><creatorcontrib>Giorgi, Fabrizio</creatorcontrib><creatorcontrib>Vigevani, Aristide</creatorcontrib><title>Synthesis and characterization of novel internal surface reversed-phase silica supports for high-performance liquid chromatography</title><title>Journal of Chromatography A</title><addtitle>J Chromatogr A</addtitle><description>An original synthetic method was developed for the preparation of a family of six novel deactivated restricted-access materials (RAMs), belonging to the group of the internal surface reversed-phase (ISRP) supports. The supports (ISRP-RAM phases A–F) have an alkyl-chain (14 methylenes) with two embedded ureido groups bound only to the internal surfaces of the porous silica, and polyvinyl alcoholic groups (PVA, 100
000
→
22
000 molecular weight) chemically bound to the external surfaces. The average pore diameters of the prepared ISRP-RAM supports, calculated by inverse size-exclusion chromatography, ranged between 49
Å and 88
Å, and were able to exclude macromolecules heavier than about 24
000
Da (such as serum proteins) from the pores. The novel supports were designed for the determination of a semi-synthetic anticancer drug of the camptothecin family in human plasma, but they represent universal ISRP-RAM supports not limited to such class of compounds.</description><subject>Analysis</subject><subject>Analytical chemistry</subject><subject>Biological and medical sciences</subject><subject>Chemistry</subject><subject>Chromatographic methods and physical methods associated with chromatography</subject><subject>Chromatography, High Pressure Liquid - instrumentation</subject><subject>Exact sciences and technology</subject><subject>Exclusion pore size ( Φe)</subject><subject>General pharmacology</subject><subject>Gimatecan</subject><subject>Hydrophilic network</subject><subject>Internal surface reversed-phase (ISRP) supports</subject><subject>Medical sciences</subject><subject>Other chromatographic methods</subject><subject>Pharmacology. Drug treatments</subject><subject>Pore size distribution (PSD)</subject><subject>Restricted-access materials (RAMs)</subject><subject>Silicon Dioxide - chemistry</subject><subject>Surface Properties</subject><issn>0021-9673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1q3DAURrVIadK0bxCKNu3OkyvZY402hRKatBDootmLa_kq1mBbjmQPTJZ98srMQHZdSXw690eHsRsBGwGivt1vbBfDgBsJoHK0gVpesCsAKQpdq_KSfUhpDyAUKPmeXYodSFlLfcX-_jmOc0fJJ45jy22HEe1M0b_i7MPIg-NjOFDP_ZjTEXuelujQEo90oJioLaYOE_Hke28xv05TiHPiLkTe-eeumCjm-4Bjrun9y-LXKeuyc3iOOHXHj-ydwz7Rp_N5zZ7ufzzd_Swefz_8uvv-WNhSw1y4StelJmiqRqhGV2itAnAlKrSqafTWKp1dOLJ6q0kIDTtoc-Zko8uyKa_Z11PbKYaXhdJsBp8s9T2OFJZkag2VltU2g9UJtDGkFMmZKfoB49EIMKtuszenH5hV95pm3bns87n_0gzUvhWdXWfgyxnAZLF3MSvx6Y3Tu12tFGTu24mjLOPgKZpkPWV9rY9kZ9MG__9N_gHndqXp</recordid><startdate>20071228</startdate><enddate>20071228</enddate><creator>Gasparrini, Francesco</creator><creator>Ciogli, Alessia</creator><creator>D’Acquarica, Ilaria</creator><creator>Misiti, Domenico</creator><creator>Badaloni, Elena</creator><creator>Giorgi, Fabrizio</creator><creator>Vigevani, Aristide</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071228</creationdate><title>Synthesis and characterization of novel internal surface reversed-phase silica supports for high-performance liquid chromatography</title><author>Gasparrini, Francesco ; Ciogli, Alessia ; D’Acquarica, Ilaria ; Misiti, Domenico ; Badaloni, Elena ; Giorgi, Fabrizio ; Vigevani, Aristide</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-f49639e0b4b17b94acc700f3a7ac7bb95c79016fec959e119080dc79f2b933b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Analysis</topic><topic>Analytical chemistry</topic><topic>Biological and medical sciences</topic><topic>Chemistry</topic><topic>Chromatographic methods and physical methods associated with chromatography</topic><topic>Chromatography, High Pressure Liquid - instrumentation</topic><topic>Exact sciences and technology</topic><topic>Exclusion pore size ( Φe)</topic><topic>General pharmacology</topic><topic>Gimatecan</topic><topic>Hydrophilic network</topic><topic>Internal surface reversed-phase (ISRP) supports</topic><topic>Medical sciences</topic><topic>Other chromatographic methods</topic><topic>Pharmacology. Drug treatments</topic><topic>Pore size distribution (PSD)</topic><topic>Restricted-access materials (RAMs)</topic><topic>Silicon Dioxide - chemistry</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gasparrini, Francesco</creatorcontrib><creatorcontrib>Ciogli, Alessia</creatorcontrib><creatorcontrib>D’Acquarica, Ilaria</creatorcontrib><creatorcontrib>Misiti, Domenico</creatorcontrib><creatorcontrib>Badaloni, Elena</creatorcontrib><creatorcontrib>Giorgi, Fabrizio</creatorcontrib><creatorcontrib>Vigevani, Aristide</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Chromatography A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gasparrini, Francesco</au><au>Ciogli, Alessia</au><au>D’Acquarica, Ilaria</au><au>Misiti, Domenico</au><au>Badaloni, Elena</au><au>Giorgi, Fabrizio</au><au>Vigevani, Aristide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and characterization of novel internal surface reversed-phase silica supports for high-performance liquid chromatography</atitle><jtitle>Journal of Chromatography A</jtitle><addtitle>J Chromatogr A</addtitle><date>2007-12-28</date><risdate>2007</risdate><volume>1176</volume><issue>1</issue><spage>79</spage><epage>88</epage><pages>79-88</pages><issn>0021-9673</issn><coden>JOCRAM</coden><abstract>An original synthetic method was developed for the preparation of a family of six novel deactivated restricted-access materials (RAMs), belonging to the group of the internal surface reversed-phase (ISRP) supports. The supports (ISRP-RAM phases A–F) have an alkyl-chain (14 methylenes) with two embedded ureido groups bound only to the internal surfaces of the porous silica, and polyvinyl alcoholic groups (PVA, 100
000
→
22
000 molecular weight) chemically bound to the external surfaces. The average pore diameters of the prepared ISRP-RAM supports, calculated by inverse size-exclusion chromatography, ranged between 49
Å and 88
Å, and were able to exclude macromolecules heavier than about 24
000
Da (such as serum proteins) from the pores. The novel supports were designed for the determination of a semi-synthetic anticancer drug of the camptothecin family in human plasma, but they represent universal ISRP-RAM supports not limited to such class of compounds.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>18022629</pmid><doi>10.1016/j.chroma.2007.10.062</doi><tpages>10</tpages></addata></record> |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Analysis Analytical chemistry Biological and medical sciences Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, High Pressure Liquid - instrumentation Exact sciences and technology Exclusion pore size ( Φe) General pharmacology Gimatecan Hydrophilic network Internal surface reversed-phase (ISRP) supports Medical sciences Other chromatographic methods Pharmacology. Drug treatments Pore size distribution (PSD) Restricted-access materials (RAMs) Silicon Dioxide - chemistry Surface Properties |
| title | Synthesis and characterization of novel internal surface reversed-phase silica supports for high-performance liquid chromatography |
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