Attenuation of Hypotension using Phenylephrine during induction of anaesthesia with Propofol
To observe if phenylephrine mixed with propofol can attenuate hypotensive effects of propofol during induction of anaesthesia. A total number of 135 adult ASA-I and ASA-II patients were divided into three groups. (Group A, B and C). All patients were induced with propofol 2.5 mg per kg. In Group A (...
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| Veröffentlicht in: | Journal of the Pakistan Medical Association 2007-11, Vol.57 (11), p.543-547 |
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| container_title | Journal of the Pakistan Medical Association |
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| creator | IMRAN, Muhammad FAZAL HAMEED KHAN MANSOOR AHMED KHAN |
| description | To observe if phenylephrine mixed with propofol can attenuate hypotensive effects of propofol during induction of anaesthesia.
A total number of 135 adult ASA-I and ASA-II patients were divided into three groups. (Group A, B and C). All patients were induced with propofol 2.5 mg per kg. In Group A (control group) patients received propofol mixed with 2cc of 0.9% normal saline. Group B (study group) patients received propofol mixed with 2cc of a solution containing phenylephrine 25 microg/cc (total 50 microg); Group C (study group) patients received propofol mixed with 2cc of a solution containing phenylephrine 50 microg/cc (total 100 microg). Haemodynamic variables like systolic, diastolic, mean arterial blood pressure and heart rate were noted. Hypotension was defined as 20% decrease in baseline systolic blood pressure recorded before induction of anaesthesia.
Phenylephrine in a dose of 100 micrograms attenuated the drop in systolic blood pressure. However phenylephrine in a dose 50 micrograms did not effectively prevent anticipated drop in SBP.
Phenylephrine in doses of 100 micrograms effectively attenuates anticipated hypotension upon induction of general anaesthesia with propofol. |
| format | Article |
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A total number of 135 adult ASA-I and ASA-II patients were divided into three groups. (Group A, B and C). All patients were induced with propofol 2.5 mg per kg. In Group A (control group) patients received propofol mixed with 2cc of 0.9% normal saline. Group B (study group) patients received propofol mixed with 2cc of a solution containing phenylephrine 25 microg/cc (total 50 microg); Group C (study group) patients received propofol mixed with 2cc of a solution containing phenylephrine 50 microg/cc (total 100 microg). Haemodynamic variables like systolic, diastolic, mean arterial blood pressure and heart rate were noted. Hypotension was defined as 20% decrease in baseline systolic blood pressure recorded before induction of anaesthesia.
Phenylephrine in a dose of 100 micrograms attenuated the drop in systolic blood pressure. However phenylephrine in a dose 50 micrograms did not effectively prevent anticipated drop in SBP.
Phenylephrine in doses of 100 micrograms effectively attenuates anticipated hypotension upon induction of general anaesthesia with propofol.</description><identifier>ISSN: 0030-9982</identifier><identifier>PMID: 18062519</identifier><identifier>CODEN: JJPAD4</identifier><language>eng</language><publisher>Karachi: Pakistan Medical Association</publisher><subject>Adolescent ; Adult ; Aged ; Anesthetics, Intravenous - pharmacology ; Anesthetics, Intravenous - therapeutic use ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiotonic Agents - pharmacology ; Cardiotonic Agents - therapeutic use ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Female ; General aspects ; Humans ; Hypotension - diagnosis ; Hypotension - etiology ; Hypotension - prevention & control ; Incidence ; Male ; Medical sciences ; Middle Aged ; Phenylephrine - pharmacology ; Phenylephrine - therapeutic use ; Propofol - pharmacology ; Propofol - therapeutic use ; Risk Factors</subject><ispartof>Journal of the Pakistan Medical Association, 2007-11, Vol.57 (11), p.543-547</ispartof><rights>2008 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20167693$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18062519$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>IMRAN, Muhammad</creatorcontrib><creatorcontrib>FAZAL HAMEED KHAN</creatorcontrib><creatorcontrib>MANSOOR AHMED KHAN</creatorcontrib><title>Attenuation of Hypotension using Phenylephrine during induction of anaesthesia with Propofol</title><title>Journal of the Pakistan Medical Association</title><addtitle>J Pak Med Assoc</addtitle><description>To observe if phenylephrine mixed with propofol can attenuate hypotensive effects of propofol during induction of anaesthesia.
A total number of 135 adult ASA-I and ASA-II patients were divided into three groups. (Group A, B and C). All patients were induced with propofol 2.5 mg per kg. In Group A (control group) patients received propofol mixed with 2cc of 0.9% normal saline. Group B (study group) patients received propofol mixed with 2cc of a solution containing phenylephrine 25 microg/cc (total 50 microg); Group C (study group) patients received propofol mixed with 2cc of a solution containing phenylephrine 50 microg/cc (total 100 microg). Haemodynamic variables like systolic, diastolic, mean arterial blood pressure and heart rate were noted. Hypotension was defined as 20% decrease in baseline systolic blood pressure recorded before induction of anaesthesia.
Phenylephrine in a dose of 100 micrograms attenuated the drop in systolic blood pressure. However phenylephrine in a dose 50 micrograms did not effectively prevent anticipated drop in SBP.
Phenylephrine in doses of 100 micrograms effectively attenuates anticipated hypotension upon induction of general anaesthesia with propofol.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anesthetics, Intravenous - pharmacology</subject><subject>Anesthetics, Intravenous - therapeutic use</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiotonic Agents - pharmacology</subject><subject>Cardiotonic Agents - therapeutic use</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Hypotension - diagnosis</subject><subject>Hypotension - etiology</subject><subject>Hypotension - prevention & control</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Phenylephrine - pharmacology</subject><subject>Phenylephrine - therapeutic use</subject><subject>Propofol - pharmacology</subject><subject>Propofol - therapeutic use</subject><subject>Risk Factors</subject><issn>0030-9982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE9LAzEUxHNQbK1-BdmL3hbyZ5NujqWoFQr2oDdhedkkbmSbrMkG6bd3i62nxwy_GR5zgeYYM1xKWdMZuk7pC2MqOMZXaEZqLCgnco4-VuNofIbRBV8EW2wOQ5iMdJQ5Of9Z7DrjD70Zuui8KXSOR9N5ndtzBjyYNHYmOSh-3NgVuxiGYEN_gy4t9Mncnu4CvT89vq035fb1-WW92pYD4dVYVlbpWnOtqRKgNJW2UszWWBnJlkRTUXPDAdqKUk5JS6xmUjGOqWVKcKLYAj389Q4xfOfpl2bvUmv6HrwJOTVC4kpOY0zg3QnMam90M0S3h3hozntMwP0JgNRCbyP41qV_jmIilkIy9gur6WpA</recordid><startdate>200711</startdate><enddate>200711</enddate><creator>IMRAN, Muhammad</creator><creator>FAZAL HAMEED KHAN</creator><creator>MANSOOR AHMED KHAN</creator><general>Pakistan Medical Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200711</creationdate><title>Attenuation of Hypotension using Phenylephrine during induction of anaesthesia with Propofol</title><author>IMRAN, Muhammad ; FAZAL HAMEED KHAN ; MANSOOR AHMED KHAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p154t-4fbd8d5dd2b6abd29f4b3f80be9371d2685e5aac422521c1fd39b3502f3b651b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anesthetics, Intravenous - pharmacology</topic><topic>Anesthetics, Intravenous - therapeutic use</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cardiotonic Agents - pharmacology</topic><topic>Cardiotonic Agents - therapeutic use</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Hypotension - diagnosis</topic><topic>Hypotension - etiology</topic><topic>Hypotension - prevention & control</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Phenylephrine - pharmacology</topic><topic>Phenylephrine - therapeutic use</topic><topic>Propofol - pharmacology</topic><topic>Propofol - therapeutic use</topic><topic>Risk Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>IMRAN, Muhammad</creatorcontrib><creatorcontrib>FAZAL HAMEED KHAN</creatorcontrib><creatorcontrib>MANSOOR AHMED KHAN</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the Pakistan Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IMRAN, Muhammad</au><au>FAZAL HAMEED KHAN</au><au>MANSOOR AHMED KHAN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Attenuation of Hypotension using Phenylephrine during induction of anaesthesia with Propofol</atitle><jtitle>Journal of the Pakistan Medical Association</jtitle><addtitle>J Pak Med Assoc</addtitle><date>2007-11</date><risdate>2007</risdate><volume>57</volume><issue>11</issue><spage>543</spage><epage>547</epage><pages>543-547</pages><issn>0030-9982</issn><coden>JJPAD4</coden><abstract>To observe if phenylephrine mixed with propofol can attenuate hypotensive effects of propofol during induction of anaesthesia.
A total number of 135 adult ASA-I and ASA-II patients were divided into three groups. (Group A, B and C). All patients were induced with propofol 2.5 mg per kg. In Group A (control group) patients received propofol mixed with 2cc of 0.9% normal saline. Group B (study group) patients received propofol mixed with 2cc of a solution containing phenylephrine 25 microg/cc (total 50 microg); Group C (study group) patients received propofol mixed with 2cc of a solution containing phenylephrine 50 microg/cc (total 100 microg). Haemodynamic variables like systolic, diastolic, mean arterial blood pressure and heart rate were noted. Hypotension was defined as 20% decrease in baseline systolic blood pressure recorded before induction of anaesthesia.
Phenylephrine in a dose of 100 micrograms attenuated the drop in systolic blood pressure. However phenylephrine in a dose 50 micrograms did not effectively prevent anticipated drop in SBP.
Phenylephrine in doses of 100 micrograms effectively attenuates anticipated hypotension upon induction of general anaesthesia with propofol.</abstract><cop>Karachi</cop><pub>Pakistan Medical Association</pub><pmid>18062519</pmid><tpages>5</tpages></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Aged Anesthetics, Intravenous - pharmacology Anesthetics, Intravenous - therapeutic use Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiotonic Agents - pharmacology Cardiotonic Agents - therapeutic use Clinical manifestations. Epidemiology. Investigative techniques. Etiology Female General aspects Humans Hypotension - diagnosis Hypotension - etiology Hypotension - prevention & control Incidence Male Medical sciences Middle Aged Phenylephrine - pharmacology Phenylephrine - therapeutic use Propofol - pharmacology Propofol - therapeutic use Risk Factors |
| title | Attenuation of Hypotension using Phenylephrine during induction of anaesthesia with Propofol |
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