Increased S100B Serum Levels in Dilated Cardiomyopathy Patients
Abstract Background The S100B protein is considered a biochemical marker for brain injuries. However, our group demonstrated that the isolated rat heart releases S100B. In this study, we investigated the serum levels of S100B in dilated cardiomyopathy (DCM) patients to evaluate its levels in heart d...
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| Veröffentlicht in: | Journal of cardiac failure 2007-12, Vol.13 (10), p.850-854 |
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| creator | Mazzini, Guilherme S., MD Schaf, Débora V., MD Vinadé, Elsa R., PhD Horowitz, Estela, MD Bruch, Ricardo S., Pharm Brunm, Liz M.B.P., Pharm Gonçalves, Carlos A., PhD Bacal, Fernando, PhD Souza, Diogo O., PhD Portela, Luis V.C., PhD Bordignon, Solange, MD |
| description | Abstract Background The S100B protein is considered a biochemical marker for brain injuries. However, our group demonstrated that the isolated rat heart releases S100B. In this study, we investigated the serum levels of S100B in dilated cardiomyopathy (DCM) patients to evaluate its levels in heart disease. Methods and Results We selected DCM patients, excluding any condition that could influence S100B serum levels. Control individuals were sex and age matched. Both groups were submitted to clinical evaluation and echocardiography. We measured the S100B and NT-proBNP serum levels (expressed as median [interquartile range]). NT-proBNP levels in patients group (1462 pg/mL [426–3591]) were higher than in controls (35 pg/mL [29–55]), P < .001. S100B serum levels were higher in patients group (0.051 μg/L [0.022–0.144]) than in controls (0.017 μg/L [0.003–0.036]), P = .009. Additionally, we found a positive correlation between S100B and NT-proBNP serum levels only in patients group (Spearman's coefficient r = 0.534; P = .013). Conclusions Although we cannot rule out the influence of S100B from brain, the positive correlation between S100B and NT-proBNP levels in DCM patients points to the myocardium as the main source for the rise in S100B serum levels. |
| doi_str_mv | 10.1016/j.cardfail.2007.07.009 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69048914</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1071916407010056</els_id><sourcerecordid>69048914</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-1dce9dcc9cb3a6baf08e1b27e16074f06e16117aff4251ea3011d6820199ad523</originalsourceid><addsrcrecordid>eNqFkVtr4zAQhUXp0uv-heKnvjmdsRXZeuktvWwhsAvpPgtFGlOlvqSSHci_X5mkFPqyMDADc2YOfIexC4QJAoqr1cRobyvt6kkGUEzGAnnATnCaZ2nJkR_GGQpMJQp-zE5DWAFAyaE4YsdYgigFyhN289IaTzqQTRYIcJ8syA9NMqcN1SFxbfLgat3H7Szaua7Zdmvdv22TP7p31PbhnP2odB3o576fsb9Pj6-zX-n89_PL7G6eGp5hn6I1JK0x0ixzLZa6gpJwmRWEAgpegYgDYqGrimdTJJ0DohVlBiilttMsP2OXu79r330MFHrVuGCornVL3RCUkMBLiTwKxU5ofBeCp0qtvWu03yoENaJTK_WJTo3o1Fgg4-HF3mFYNmS_zvasouB2J4hkaOPIq2AiA0PWeTK9sp37v8f1txemdq0zun6nLYVVN_g2UlSoQqZALcYAx_yggBjOVOT_AP3hlmU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69048914</pqid></control><display><type>article</type><title>Increased S100B Serum Levels in Dilated Cardiomyopathy Patients</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Mazzini, Guilherme S., MD ; Schaf, Débora V., MD ; Vinadé, Elsa R., PhD ; Horowitz, Estela, MD ; Bruch, Ricardo S., Pharm ; Brunm, Liz M.B.P., Pharm ; Gonçalves, Carlos A., PhD ; Bacal, Fernando, PhD ; Souza, Diogo O., PhD ; Portela, Luis V.C., PhD ; Bordignon, Solange, MD</creator><creatorcontrib>Mazzini, Guilherme S., MD ; Schaf, Débora V., MD ; Vinadé, Elsa R., PhD ; Horowitz, Estela, MD ; Bruch, Ricardo S., Pharm ; Brunm, Liz M.B.P., Pharm ; Gonçalves, Carlos A., PhD ; Bacal, Fernando, PhD ; Souza, Diogo O., PhD ; Portela, Luis V.C., PhD ; Bordignon, Solange, MD</creatorcontrib><description>Abstract Background The S100B protein is considered a biochemical marker for brain injuries. However, our group demonstrated that the isolated rat heart releases S100B. In this study, we investigated the serum levels of S100B in dilated cardiomyopathy (DCM) patients to evaluate its levels in heart disease. Methods and Results We selected DCM patients, excluding any condition that could influence S100B serum levels. Control individuals were sex and age matched. Both groups were submitted to clinical evaluation and echocardiography. We measured the S100B and NT-proBNP serum levels (expressed as median [interquartile range]). NT-proBNP levels in patients group (1462 pg/mL [426–3591]) were higher than in controls (35 pg/mL [29–55]), P < .001. S100B serum levels were higher in patients group (0.051 μg/L [0.022–0.144]) than in controls (0.017 μg/L [0.003–0.036]), P = .009. Additionally, we found a positive correlation between S100B and NT-proBNP serum levels only in patients group (Spearman's coefficient r = 0.534; P = .013). Conclusions Although we cannot rule out the influence of S100B from brain, the positive correlation between S100B and NT-proBNP levels in DCM patients points to the myocardium as the main source for the rise in S100B serum levels.</description><identifier>ISSN: 1071-9164</identifier><identifier>EISSN: 1532-8414</identifier><identifier>DOI: 10.1016/j.cardfail.2007.07.009</identifier><identifier>PMID: 18068619</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Biomarkers - blood ; Cardiomyopathy, Dilated - blood ; Cardiomyopathy, Dilated - diagnostic imaging ; Cardiomyopathy, Dilated - physiopathology ; Cardiovascular ; Disease Progression ; Echocardiography ; Female ; Follow-Up Studies ; Heart failure ; Humans ; Immunoassay ; Male ; Middle Aged ; Natriuretic Peptide, Brain - blood ; natriuretic peptides ; Nerve Growth Factors - blood ; NT-proBNP ; Peptide Fragments - blood ; Prognosis ; Protein Precursors ; S100 Calcium Binding Protein beta Subunit ; S100 Proteins - blood ; Severity of Illness Index ; Stroke Volume</subject><ispartof>Journal of cardiac failure, 2007-12, Vol.13 (10), p.850-854</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-1dce9dcc9cb3a6baf08e1b27e16074f06e16117aff4251ea3011d6820199ad523</citedby><cites>FETCH-LOGICAL-c421t-1dce9dcc9cb3a6baf08e1b27e16074f06e16117aff4251ea3011d6820199ad523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cardfail.2007.07.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18068619$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mazzini, Guilherme S., MD</creatorcontrib><creatorcontrib>Schaf, Débora V., MD</creatorcontrib><creatorcontrib>Vinadé, Elsa R., PhD</creatorcontrib><creatorcontrib>Horowitz, Estela, MD</creatorcontrib><creatorcontrib>Bruch, Ricardo S., Pharm</creatorcontrib><creatorcontrib>Brunm, Liz M.B.P., Pharm</creatorcontrib><creatorcontrib>Gonçalves, Carlos A., PhD</creatorcontrib><creatorcontrib>Bacal, Fernando, PhD</creatorcontrib><creatorcontrib>Souza, Diogo O., PhD</creatorcontrib><creatorcontrib>Portela, Luis V.C., PhD</creatorcontrib><creatorcontrib>Bordignon, Solange, MD</creatorcontrib><title>Increased S100B Serum Levels in Dilated Cardiomyopathy Patients</title><title>Journal of cardiac failure</title><addtitle>J Card Fail</addtitle><description>Abstract Background The S100B protein is considered a biochemical marker for brain injuries. However, our group demonstrated that the isolated rat heart releases S100B. In this study, we investigated the serum levels of S100B in dilated cardiomyopathy (DCM) patients to evaluate its levels in heart disease. Methods and Results We selected DCM patients, excluding any condition that could influence S100B serum levels. Control individuals were sex and age matched. Both groups were submitted to clinical evaluation and echocardiography. We measured the S100B and NT-proBNP serum levels (expressed as median [interquartile range]). NT-proBNP levels in patients group (1462 pg/mL [426–3591]) were higher than in controls (35 pg/mL [29–55]), P < .001. S100B serum levels were higher in patients group (0.051 μg/L [0.022–0.144]) than in controls (0.017 μg/L [0.003–0.036]), P = .009. Additionally, we found a positive correlation between S100B and NT-proBNP serum levels only in patients group (Spearman's coefficient r = 0.534; P = .013). Conclusions Although we cannot rule out the influence of S100B from brain, the positive correlation between S100B and NT-proBNP levels in DCM patients points to the myocardium as the main source for the rise in S100B serum levels.</description><subject>Biomarkers - blood</subject><subject>Cardiomyopathy, Dilated - blood</subject><subject>Cardiomyopathy, Dilated - diagnostic imaging</subject><subject>Cardiomyopathy, Dilated - physiopathology</subject><subject>Cardiovascular</subject><subject>Disease Progression</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart failure</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>natriuretic peptides</subject><subject>Nerve Growth Factors - blood</subject><subject>NT-proBNP</subject><subject>Peptide Fragments - blood</subject><subject>Prognosis</subject><subject>Protein Precursors</subject><subject>S100 Calcium Binding Protein beta Subunit</subject><subject>S100 Proteins - blood</subject><subject>Severity of Illness Index</subject><subject>Stroke Volume</subject><issn>1071-9164</issn><issn>1532-8414</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVtr4zAQhUXp0uv-heKnvjmdsRXZeuktvWwhsAvpPgtFGlOlvqSSHci_X5mkFPqyMDADc2YOfIexC4QJAoqr1cRobyvt6kkGUEzGAnnATnCaZ2nJkR_GGQpMJQp-zE5DWAFAyaE4YsdYgigFyhN289IaTzqQTRYIcJ8syA9NMqcN1SFxbfLgat3H7Szaua7Zdmvdv22TP7p31PbhnP2odB3o576fsb9Pj6-zX-n89_PL7G6eGp5hn6I1JK0x0ixzLZa6gpJwmRWEAgpegYgDYqGrimdTJJ0DohVlBiilttMsP2OXu79r330MFHrVuGCornVL3RCUkMBLiTwKxU5ofBeCp0qtvWu03yoENaJTK_WJTo3o1Fgg4-HF3mFYNmS_zvasouB2J4hkaOPIq2AiA0PWeTK9sp37v8f1txemdq0zun6nLYVVN_g2UlSoQqZALcYAx_yggBjOVOT_AP3hlmU</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>Mazzini, Guilherme S., MD</creator><creator>Schaf, Débora V., MD</creator><creator>Vinadé, Elsa R., PhD</creator><creator>Horowitz, Estela, MD</creator><creator>Bruch, Ricardo S., Pharm</creator><creator>Brunm, Liz M.B.P., Pharm</creator><creator>Gonçalves, Carlos A., PhD</creator><creator>Bacal, Fernando, PhD</creator><creator>Souza, Diogo O., PhD</creator><creator>Portela, Luis V.C., PhD</creator><creator>Bordignon, Solange, MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071201</creationdate><title>Increased S100B Serum Levels in Dilated Cardiomyopathy Patients</title><author>Mazzini, Guilherme S., MD ; Schaf, Débora V., MD ; Vinadé, Elsa R., PhD ; Horowitz, Estela, MD ; Bruch, Ricardo S., Pharm ; Brunm, Liz M.B.P., Pharm ; Gonçalves, Carlos A., PhD ; Bacal, Fernando, PhD ; Souza, Diogo O., PhD ; Portela, Luis V.C., PhD ; Bordignon, Solange, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-1dce9dcc9cb3a6baf08e1b27e16074f06e16117aff4251ea3011d6820199ad523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biomarkers - blood</topic><topic>Cardiomyopathy, Dilated - blood</topic><topic>Cardiomyopathy, Dilated - diagnostic imaging</topic><topic>Cardiomyopathy, Dilated - physiopathology</topic><topic>Cardiovascular</topic><topic>Disease Progression</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart failure</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>natriuretic peptides</topic><topic>Nerve Growth Factors - blood</topic><topic>NT-proBNP</topic><topic>Peptide Fragments - blood</topic><topic>Prognosis</topic><topic>Protein Precursors</topic><topic>S100 Calcium Binding Protein beta Subunit</topic><topic>S100 Proteins - blood</topic><topic>Severity of Illness Index</topic><topic>Stroke Volume</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mazzini, Guilherme S., MD</creatorcontrib><creatorcontrib>Schaf, Débora V., MD</creatorcontrib><creatorcontrib>Vinadé, Elsa R., PhD</creatorcontrib><creatorcontrib>Horowitz, Estela, MD</creatorcontrib><creatorcontrib>Bruch, Ricardo S., Pharm</creatorcontrib><creatorcontrib>Brunm, Liz M.B.P., Pharm</creatorcontrib><creatorcontrib>Gonçalves, Carlos A., PhD</creatorcontrib><creatorcontrib>Bacal, Fernando, PhD</creatorcontrib><creatorcontrib>Souza, Diogo O., PhD</creatorcontrib><creatorcontrib>Portela, Luis V.C., PhD</creatorcontrib><creatorcontrib>Bordignon, Solange, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiac failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mazzini, Guilherme S., MD</au><au>Schaf, Débora V., MD</au><au>Vinadé, Elsa R., PhD</au><au>Horowitz, Estela, MD</au><au>Bruch, Ricardo S., Pharm</au><au>Brunm, Liz M.B.P., Pharm</au><au>Gonçalves, Carlos A., PhD</au><au>Bacal, Fernando, PhD</au><au>Souza, Diogo O., PhD</au><au>Portela, Luis V.C., PhD</au><au>Bordignon, Solange, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased S100B Serum Levels in Dilated Cardiomyopathy Patients</atitle><jtitle>Journal of cardiac failure</jtitle><addtitle>J Card Fail</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>13</volume><issue>10</issue><spage>850</spage><epage>854</epage><pages>850-854</pages><issn>1071-9164</issn><eissn>1532-8414</eissn><abstract>Abstract Background The S100B protein is considered a biochemical marker for brain injuries. However, our group demonstrated that the isolated rat heart releases S100B. In this study, we investigated the serum levels of S100B in dilated cardiomyopathy (DCM) patients to evaluate its levels in heart disease. Methods and Results We selected DCM patients, excluding any condition that could influence S100B serum levels. Control individuals were sex and age matched. Both groups were submitted to clinical evaluation and echocardiography. We measured the S100B and NT-proBNP serum levels (expressed as median [interquartile range]). NT-proBNP levels in patients group (1462 pg/mL [426–3591]) were higher than in controls (35 pg/mL [29–55]), P < .001. S100B serum levels were higher in patients group (0.051 μg/L [0.022–0.144]) than in controls (0.017 μg/L [0.003–0.036]), P = .009. Additionally, we found a positive correlation between S100B and NT-proBNP serum levels only in patients group (Spearman's coefficient r = 0.534; P = .013). Conclusions Although we cannot rule out the influence of S100B from brain, the positive correlation between S100B and NT-proBNP levels in DCM patients points to the myocardium as the main source for the rise in S100B serum levels.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18068619</pmid><doi>10.1016/j.cardfail.2007.07.009</doi><tpages>5</tpages></addata></record> |
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| subjects | Biomarkers - blood Cardiomyopathy, Dilated - blood Cardiomyopathy, Dilated - diagnostic imaging Cardiomyopathy, Dilated - physiopathology Cardiovascular Disease Progression Echocardiography Female Follow-Up Studies Heart failure Humans Immunoassay Male Middle Aged Natriuretic Peptide, Brain - blood natriuretic peptides Nerve Growth Factors - blood NT-proBNP Peptide Fragments - blood Prognosis Protein Precursors S100 Calcium Binding Protein beta Subunit S100 Proteins - blood Severity of Illness Index Stroke Volume |
| title | Increased S100B Serum Levels in Dilated Cardiomyopathy Patients |
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