Localized scleroderma and systemic sclerosis: Is there a connection?
Excess fibrosis of the skin is a clinical hallmark of both localized scleroderma and systemic sclerosis. Localized scleroderma is generally thought to be a skin-limited disease whereas systemic sclerosis can have a wide range of internal organ involvement. Recent data suggest that a subset of patien...
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| Veröffentlicht in: | Best practice & research. Clinical rheumatology 2007-12, Vol.21 (6), p.1025-1036 |
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| container_title | Best practice & research. Clinical rheumatology |
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| creator | Gupta, Rajnish A., MD, PhD Fiorentino, David, MD, PhD |
| description | Excess fibrosis of the skin is a clinical hallmark of both localized scleroderma and systemic sclerosis. Localized scleroderma is generally thought to be a skin-limited disease whereas systemic sclerosis can have a wide range of internal organ involvement. Recent data suggest that a subset of patients with juvenile localized scleroderma can go on to develop systemic involvement of their disease. This raises the question of what the connection is, if any, between localized scleroderma and systemic sclerosis. |
| doi_str_mv | 10.1016/j.berh.2007.09.003 |
| format | Article |
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Localized scleroderma is generally thought to be a skin-limited disease whereas systemic sclerosis can have a wide range of internal organ involvement. Recent data suggest that a subset of patients with juvenile localized scleroderma can go on to develop systemic involvement of their disease. This raises the question of what the connection is, if any, between localized scleroderma and systemic sclerosis.</description><identifier>ISSN: 1521-6942</identifier><identifier>EISSN: 1532-1770</identifier><identifier>DOI: 10.1016/j.berh.2007.09.003</identifier><identifier>PMID: 18068859</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Diagnosis, Differential ; Global Health ; Humans ; Immunity, Cellular ; juvenile localized scleroderma ; localized scleroderma ; Morbidity ; morphea ; Rheumatology ; Risk Factors ; Scleroderma, Localized - diagnosis ; Scleroderma, Localized - epidemiology ; Scleroderma, Localized - etiology ; Scleroderma, Systemic - diagnosis ; Scleroderma, Systemic - epidemiology ; Scleroderma, Systemic - etiology ; systemic sclerosis ; tissue fibrosis</subject><ispartof>Best practice & research. 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| fulltext | fulltext |
| identifier | ISSN: 1521-6942 |
| ispartof | Best practice & research. Clinical rheumatology, 2007-12, Vol.21 (6), p.1025-1036 |
| issn | 1521-6942 1532-1770 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Diagnosis, Differential Global Health Humans Immunity, Cellular juvenile localized scleroderma localized scleroderma Morbidity morphea Rheumatology Risk Factors Scleroderma, Localized - diagnosis Scleroderma, Localized - epidemiology Scleroderma, Localized - etiology Scleroderma, Systemic - diagnosis Scleroderma, Systemic - epidemiology Scleroderma, Systemic - etiology systemic sclerosis tissue fibrosis |
| title | Localized scleroderma and systemic sclerosis: Is there a connection? |
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