Novel CpG-free Vertebrate Insulator Silences the Testis-specific SP-10 Gene in Somatic Tissues: ROLE FOR TDP-43 IN INSULATOR FUNCTION

Regulation of cell type-specific gene transcription is central to cellular differentiation and development. During spermatogenesis, a number of testis-specific genes are expressed in a precise spatiotemporal order. How these genes remain silent in the somatic tissues is not well understood. Our prev...

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Veröffentlicht in:	The Journal of biological chemistry 2007-12, Vol.282 (50), p.36143-36154
Hauptverfasser:	Abhyankar, Mayuresh M, Urekar, Craig, Reddi, Prabhakara P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chlorocebus aethiops COS Cells CpG Islands - genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enhancer Elements, Genetic - physiology Gene Expression Regulation - physiology Gene Silencing Insulator Elements - physiology Male Membrane Proteins - biosynthesis Membrane Proteins - genetics Mice Mice, Transgenic Mutation Nuclear Matrix - genetics Nuclear Matrix - metabolism Organ Specificity - physiology Promoter Regions, Genetic - physiology Protein Binding - physiology Spermatids - cytology Spermatids - metabolism Testis - cytology Testis - metabolism
Online-Zugang:	Volltext
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