The postacrosomal assembly of sperm head protein, PAWP, is independent of acrosome formation and dependent on microtubular manchette transport

PAWP (postacrosomal sheath WW domain-binding protein) exclusively resides in the postacrosomal sheath (PAS) of the sperm perinuclear theca (PT). Because of the importance of this region in initiating oocyte activation during mammalian fertilization [Sutovsky, P., Manandhar, G., Wu, A., Oko, R., 2003...

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Veröffentlicht in:	Developmental biology 2007-12, Vol.312 (2), p.471-483
Hauptverfasser:	Wu, Alexander T.H., Sutovsky, Peter, Xu, Wei, van der Spoel, Aarnoud C., Platt, Frances M., Oko, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrosome - physiology Acrosomeless sperm Animals Biological Transport Carrier Proteins - genetics Carrier Proteins - metabolism Fluorescent Antibody Technique Male Mice Mice, Inbred C57BL Microtubular manchette Microtubules - metabolism NB-DNJ treatment PAWP protein Perinuclear theca Postacrosomal sheath Postacrosomal sheath assembly Seminal Plasma Proteins - genetics Seminal Plasma Proteins - metabolism Sperm Spermatogenesis Spermatozoa - ultrastructure Spermiogenesis Testis - metabolism Tubulin - metabolism
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