Phosphatidylinositol transfer protein-α in netrin-1-induced PLC signalling and neurite outgrowth

Neurite extension is essential for wiring the nervous system during development. Although several factors are known to regulate neurite outgrowth, the underlying mechanisms remain unclear. Here, we provide evidence for a role of phosphatidylinositol transfer protein-α (PITPα) in neurite extension in...

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Veröffentlicht in:	Nature cell biology 2005-11, Vol.7 (11), p.1124-1132
Hauptverfasser:	Xiong, Wen-Cheng, Xie, Yi, Ding, Yu-Qiang, Hong, Yan, Feng, Zhu, Navarre, Sammy, Xi, Cai-Xia, Zhu, Xiao-Juan, Wang, Chun-Lei, Ackerman, S. L, Kozlowski, David, Mei, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Cancer Research Cell Biology Cells, Cultured Cellular signal transduction Chick Embryo - cytology Chick Embryo - metabolism Danio rerio DCC Receptor Developmental Biology Humans letter Life Sciences Lipid Metabolism - physiology Membrane proteins Membrane Proteins - metabolism Membrane Proteins - physiology Nerve Growth Factors - physiology Netrin-1 Neurites - metabolism Neurons - cytology Neurons - metabolism Phosphatidylinositol Phosphatidylinositol 4,5-Diphosphate - metabolism Phospholipid Transfer Proteins - metabolism Phospholipid Transfer Proteins - physiology Physiological aspects Receptors, Cell Surface - metabolism Signal Transduction - drug effects Stem Cells Transfection Tumor Suppressor Proteins - metabolism Tumor Suppressor Proteins - physiology Zebrafish - embryology Zebrafish - physiology Zebrafish Proteins
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