Use of the Liver Tissue Oxygenation Index as a Noninvasive Parameter of Intestinal Ischemia in Rabbits
Objective The tissue oxygenation index (TOI), measured by spatially resolved spectroscopy (SRS), reflects the ratio between oxygenated and deoxygenated tissue hemoglobin. We investigated whether liver TOI is a noninvasive parameter for early detection of intestinal ischemia. Methods In seven adult N...
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| Veröffentlicht in: | World journal of surgery 2007-12, Vol.31 (12), p.2359-2362 |
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| creator | Vanderhaegen, J. Dehing, L. Naulaers, G. Devlieger, H. Al‐Olayet, Y. Penninckx, F. Miserez, M. |
| description | Objective
The tissue oxygenation index (TOI), measured by spatially resolved spectroscopy (SRS), reflects the ratio between oxygenated and deoxygenated tissue hemoglobin. We investigated whether liver TOI is a noninvasive parameter for early detection of intestinal ischemia.
Methods
In seven adult New Zealand rabbits the superior mesenteric artery (SMA) and vein were exposed by laparotomy. The SRS probe was attached at the skin above the liver to calculate the TOI. The bowel (SbO2) and peripheral (SpO2) oxygen saturation were continuously measured. The SMA was occluded, creating small bowel ischemia for 90 minutes. Then reperfusion was started for 1 hour. The median TOI and interquartile range (IQR) of the TOI were calculated. A paired Wilcoxon test was used to evaluate changes in the liver TOI and SpO2 during ischemia and reperfusion.
Results
The median TOI was 54.3% (IQR 8) at the start of ischemia, 54.9% (IQR 9) after 30 minutes, 51% (IQR 11) after 60 minutes, and 50.3% (IQR 10) after 90 minutes. The median TOI values were 46.3% (IQR 5) after 30 minutes of reperfusion and 41.2% (IQR 5) after 60 minutes. The decrease in TOI became significant (p < 0.05) after 90 minutes of ischemia. The SpO2 was stable during the experiment.
Discussion
A significant decrease in liver TOI was seen after 90 minutes of occlusion of the SMA and is likely to be the consequence of bowel ischemia. The further decrease after reperfusion might reflect reperfusion injury. Liver TOI may be a new tool for noninvasive early detection of intestinal ischemia and reperfusion. Further study is needed to confirm these findings. |
| doi_str_mv | 10.1007/s00268-007-9269-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69044060</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2664675526</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4349-8c46769ea1c79cf666c45d3e775bbeb8a9c1ac9750c450b46cff48b169a5c8b53</originalsourceid><addsrcrecordid>eNqF0lFrFDEQB_Agij2rH8AXCYq-rSa72ezOYy1WTw4r2uJjmOSyNmU3WzO7tfvtzXEHBUF8yhB-Mxn4h7HnUryVQjTvSIhSt0UuCyg1FMsDtpKqKouyKquHbCUqrXItqyP2hOhaCNlooR-zI9lAXSpQK9Zdkudjx6crzzfh1id-EYhmz8_vlp8-4hTGyNdx6-84Ekf-ZYwh3iJlyr9iwsFPuScPWMfJ0xQi9nxN7soPAXmI_BtaGyZ6yh512JN_djiP2eXZh4vTT8Xm_OP69GRTOFUpKFqndKPBo3QNuE5r7VS9rXzT1NZ62yI4iQ6aWuR7YZV2XadaKzVg7VpbV8fszX7uTRp_zXkhMwRyvu8x-nEmo0EoJbTI8NVf8HqcU96eTKl13qKuS53Vy38qCZAhyIzkHrk0EiXfmZsUBkyLkcLscjL7nMyu3OVkltzz4jB4toPf3nccgsng9QEgOey7hNEFuncANeQ4s4O9-x16v_z_ZfPj8_f3Z_ljAFR_ABGEqzk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219966491</pqid></control><display><type>article</type><title>Use of the Liver Tissue Oxygenation Index as a Noninvasive Parameter of Intestinal Ischemia in Rabbits</title><source>MEDLINE</source><source>SpringerNature Complete Journals</source><source>Wiley Online Library All Journals</source><creator>Vanderhaegen, J. ; Dehing, L. ; Naulaers, G. ; Devlieger, H. ; Al‐Olayet, Y. ; Penninckx, F. ; Miserez, M.</creator><creatorcontrib>Vanderhaegen, J. ; Dehing, L. ; Naulaers, G. ; Devlieger, H. ; Al‐Olayet, Y. ; Penninckx, F. ; Miserez, M.</creatorcontrib><description>Objective
The tissue oxygenation index (TOI), measured by spatially resolved spectroscopy (SRS), reflects the ratio between oxygenated and deoxygenated tissue hemoglobin. We investigated whether liver TOI is a noninvasive parameter for early detection of intestinal ischemia.
Methods
In seven adult New Zealand rabbits the superior mesenteric artery (SMA) and vein were exposed by laparotomy. The SRS probe was attached at the skin above the liver to calculate the TOI. The bowel (SbO2) and peripheral (SpO2) oxygen saturation were continuously measured. The SMA was occluded, creating small bowel ischemia for 90 minutes. Then reperfusion was started for 1 hour. The median TOI and interquartile range (IQR) of the TOI were calculated. A paired Wilcoxon test was used to evaluate changes in the liver TOI and SpO2 during ischemia and reperfusion.
Results
The median TOI was 54.3% (IQR 8) at the start of ischemia, 54.9% (IQR 9) after 30 minutes, 51% (IQR 11) after 60 minutes, and 50.3% (IQR 10) after 90 minutes. The median TOI values were 46.3% (IQR 5) after 30 minutes of reperfusion and 41.2% (IQR 5) after 60 minutes. The decrease in TOI became significant (p < 0.05) after 90 minutes of ischemia. The SpO2 was stable during the experiment.
Discussion
A significant decrease in liver TOI was seen after 90 minutes of occlusion of the SMA and is likely to be the consequence of bowel ischemia. The further decrease after reperfusion might reflect reperfusion injury. Liver TOI may be a new tool for noninvasive early detection of intestinal ischemia and reperfusion. Further study is needed to confirm these findings.</description><identifier>ISSN: 0364-2313</identifier><identifier>EISSN: 1432-2323</identifier><identifier>DOI: 10.1007/s00268-007-9269-y</identifier><identifier>PMID: 17952494</identifier><identifier>CODEN: WJSUDI</identifier><language>eng</language><publisher>New York: Springer‐Verlag</publisher><subject>Animals ; Biological and medical sciences ; Biomarkers - blood ; Central Venous Oxygen Saturation ; Deoxygenation ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Hemoglobin ; Hemoglobins - analysis ; Intestinal Ischemia ; Intestines - blood supply ; Ischemia ; Ischemia - blood ; Ischemia - diagnosis ; Liver ; Liver - physiology ; Mathematical analysis ; Medical sciences ; Occlusion ; Other diseases. Semiology ; Oxygen Consumption - physiology ; Oxygen content ; Oxygenation ; Oxyhemoglobins - analysis ; Paired Wilcoxon Test ; Parameters ; Peripheral Oxygen Saturation ; Rabbits ; Reperfusion ; Reproducibility of Results ; Small intestine ; Spectroscopy ; Spectrum Analysis - methods ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Superior Mesenteric Artery ; Tissues</subject><ispartof>World journal of surgery, 2007-12, Vol.31 (12), p.2359-2362</ispartof><rights>2007 The Author(s) under exclusive licence to Société Internationale de Chirurgie</rights><rights>2008 INIST-CNRS</rights><rights>Société Internationale de Chirurgie 2007</rights><rights>Société Internationale de Chirurgie 2007.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4349-8c46769ea1c79cf666c45d3e775bbeb8a9c1ac9750c450b46cff48b169a5c8b53</citedby><cites>FETCH-LOGICAL-c4349-8c46769ea1c79cf666c45d3e775bbeb8a9c1ac9750c450b46cff48b169a5c8b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1007%2Fs00268-007-9269-y$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1007%2Fs00268-007-9269-y$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19959017$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17952494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vanderhaegen, J.</creatorcontrib><creatorcontrib>Dehing, L.</creatorcontrib><creatorcontrib>Naulaers, G.</creatorcontrib><creatorcontrib>Devlieger, H.</creatorcontrib><creatorcontrib>Al‐Olayet, Y.</creatorcontrib><creatorcontrib>Penninckx, F.</creatorcontrib><creatorcontrib>Miserez, M.</creatorcontrib><title>Use of the Liver Tissue Oxygenation Index as a Noninvasive Parameter of Intestinal Ischemia in Rabbits</title><title>World journal of surgery</title><addtitle>World J Surg</addtitle><description>Objective
The tissue oxygenation index (TOI), measured by spatially resolved spectroscopy (SRS), reflects the ratio between oxygenated and deoxygenated tissue hemoglobin. We investigated whether liver TOI is a noninvasive parameter for early detection of intestinal ischemia.
Methods
In seven adult New Zealand rabbits the superior mesenteric artery (SMA) and vein were exposed by laparotomy. The SRS probe was attached at the skin above the liver to calculate the TOI. The bowel (SbO2) and peripheral (SpO2) oxygen saturation were continuously measured. The SMA was occluded, creating small bowel ischemia for 90 minutes. Then reperfusion was started for 1 hour. The median TOI and interquartile range (IQR) of the TOI were calculated. A paired Wilcoxon test was used to evaluate changes in the liver TOI and SpO2 during ischemia and reperfusion.
Results
The median TOI was 54.3% (IQR 8) at the start of ischemia, 54.9% (IQR 9) after 30 minutes, 51% (IQR 11) after 60 minutes, and 50.3% (IQR 10) after 90 minutes. The median TOI values were 46.3% (IQR 5) after 30 minutes of reperfusion and 41.2% (IQR 5) after 60 minutes. The decrease in TOI became significant (p < 0.05) after 90 minutes of ischemia. The SpO2 was stable during the experiment.
Discussion
A significant decrease in liver TOI was seen after 90 minutes of occlusion of the SMA and is likely to be the consequence of bowel ischemia. The further decrease after reperfusion might reflect reperfusion injury. Liver TOI may be a new tool for noninvasive early detection of intestinal ischemia and reperfusion. Further study is needed to confirm these findings.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Central Venous Oxygen Saturation</subject><subject>Deoxygenation</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General aspects</subject><subject>Hemoglobin</subject><subject>Hemoglobins - analysis</subject><subject>Intestinal Ischemia</subject><subject>Intestines - blood supply</subject><subject>Ischemia</subject><subject>Ischemia - blood</subject><subject>Ischemia - diagnosis</subject><subject>Liver</subject><subject>Liver - physiology</subject><subject>Mathematical analysis</subject><subject>Medical sciences</subject><subject>Occlusion</subject><subject>Other diseases. Semiology</subject><subject>Oxygen Consumption - physiology</subject><subject>Oxygen content</subject><subject>Oxygenation</subject><subject>Oxyhemoglobins - analysis</subject><subject>Paired Wilcoxon Test</subject><subject>Parameters</subject><subject>Peripheral Oxygen Saturation</subject><subject>Rabbits</subject><subject>Reperfusion</subject><subject>Reproducibility of Results</subject><subject>Small intestine</subject><subject>Spectroscopy</subject><subject>Spectrum Analysis - methods</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Superior Mesenteric Artery</subject><subject>Tissues</subject><issn>0364-2313</issn><issn>1432-2323</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqF0lFrFDEQB_Agij2rH8AXCYq-rSa72ezOYy1WTw4r2uJjmOSyNmU3WzO7tfvtzXEHBUF8yhB-Mxn4h7HnUryVQjTvSIhSt0UuCyg1FMsDtpKqKouyKquHbCUqrXItqyP2hOhaCNlooR-zI9lAXSpQK9Zdkudjx6crzzfh1id-EYhmz8_vlp8-4hTGyNdx6-84Ekf-ZYwh3iJlyr9iwsFPuScPWMfJ0xQi9nxN7soPAXmI_BtaGyZ6yh512JN_djiP2eXZh4vTT8Xm_OP69GRTOFUpKFqndKPBo3QNuE5r7VS9rXzT1NZ62yI4iQ6aWuR7YZV2XadaKzVg7VpbV8fszX7uTRp_zXkhMwRyvu8x-nEmo0EoJbTI8NVf8HqcU96eTKl13qKuS53Vy38qCZAhyIzkHrk0EiXfmZsUBkyLkcLscjL7nMyu3OVkltzz4jB4toPf3nccgsng9QEgOey7hNEFuncANeQ4s4O9-x16v_z_ZfPj8_f3Z_ljAFR_ABGEqzk</recordid><startdate>200712</startdate><enddate>200712</enddate><creator>Vanderhaegen, J.</creator><creator>Dehing, L.</creator><creator>Naulaers, G.</creator><creator>Devlieger, H.</creator><creator>Al‐Olayet, Y.</creator><creator>Penninckx, F.</creator><creator>Miserez, M.</creator><general>Springer‐Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200712</creationdate><title>Use of the Liver Tissue Oxygenation Index as a Noninvasive Parameter of Intestinal Ischemia in Rabbits</title><author>Vanderhaegen, J. ; Dehing, L. ; Naulaers, G. ; Devlieger, H. ; Al‐Olayet, Y. ; Penninckx, F. ; Miserez, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4349-8c46769ea1c79cf666c45d3e775bbeb8a9c1ac9750c450b46cff48b169a5c8b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Central Venous Oxygen Saturation</topic><topic>Deoxygenation</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>General aspects</topic><topic>Hemoglobin</topic><topic>Hemoglobins - analysis</topic><topic>Intestinal Ischemia</topic><topic>Intestines - blood supply</topic><topic>Ischemia</topic><topic>Ischemia - blood</topic><topic>Ischemia - diagnosis</topic><topic>Liver</topic><topic>Liver - physiology</topic><topic>Mathematical analysis</topic><topic>Medical sciences</topic><topic>Occlusion</topic><topic>Other diseases. Semiology</topic><topic>Oxygen Consumption - physiology</topic><topic>Oxygen content</topic><topic>Oxygenation</topic><topic>Oxyhemoglobins - analysis</topic><topic>Paired Wilcoxon Test</topic><topic>Parameters</topic><topic>Peripheral Oxygen Saturation</topic><topic>Rabbits</topic><topic>Reperfusion</topic><topic>Reproducibility of Results</topic><topic>Small intestine</topic><topic>Spectroscopy</topic><topic>Spectrum Analysis - methods</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Superior Mesenteric Artery</topic><topic>Tissues</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vanderhaegen, J.</creatorcontrib><creatorcontrib>Dehing, L.</creatorcontrib><creatorcontrib>Naulaers, G.</creatorcontrib><creatorcontrib>Devlieger, H.</creatorcontrib><creatorcontrib>Al‐Olayet, Y.</creatorcontrib><creatorcontrib>Penninckx, F.</creatorcontrib><creatorcontrib>Miserez, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vanderhaegen, J.</au><au>Dehing, L.</au><au>Naulaers, G.</au><au>Devlieger, H.</au><au>Al‐Olayet, Y.</au><au>Penninckx, F.</au><au>Miserez, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of the Liver Tissue Oxygenation Index as a Noninvasive Parameter of Intestinal Ischemia in Rabbits</atitle><jtitle>World journal of surgery</jtitle><addtitle>World J Surg</addtitle><date>2007-12</date><risdate>2007</risdate><volume>31</volume><issue>12</issue><spage>2359</spage><epage>2362</epage><pages>2359-2362</pages><issn>0364-2313</issn><eissn>1432-2323</eissn><coden>WJSUDI</coden><abstract>Objective
The tissue oxygenation index (TOI), measured by spatially resolved spectroscopy (SRS), reflects the ratio between oxygenated and deoxygenated tissue hemoglobin. We investigated whether liver TOI is a noninvasive parameter for early detection of intestinal ischemia.
Methods
In seven adult New Zealand rabbits the superior mesenteric artery (SMA) and vein were exposed by laparotomy. The SRS probe was attached at the skin above the liver to calculate the TOI. The bowel (SbO2) and peripheral (SpO2) oxygen saturation were continuously measured. The SMA was occluded, creating small bowel ischemia for 90 minutes. Then reperfusion was started for 1 hour. The median TOI and interquartile range (IQR) of the TOI were calculated. A paired Wilcoxon test was used to evaluate changes in the liver TOI and SpO2 during ischemia and reperfusion.
Results
The median TOI was 54.3% (IQR 8) at the start of ischemia, 54.9% (IQR 9) after 30 minutes, 51% (IQR 11) after 60 minutes, and 50.3% (IQR 10) after 90 minutes. The median TOI values were 46.3% (IQR 5) after 30 minutes of reperfusion and 41.2% (IQR 5) after 60 minutes. The decrease in TOI became significant (p < 0.05) after 90 minutes of ischemia. The SpO2 was stable during the experiment.
Discussion
A significant decrease in liver TOI was seen after 90 minutes of occlusion of the SMA and is likely to be the consequence of bowel ischemia. The further decrease after reperfusion might reflect reperfusion injury. Liver TOI may be a new tool for noninvasive early detection of intestinal ischemia and reperfusion. Further study is needed to confirm these findings.</abstract><cop>New York</cop><pub>Springer‐Verlag</pub><pmid>17952494</pmid><doi>10.1007/s00268-007-9269-y</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Biomarkers - blood Central Venous Oxygen Saturation Deoxygenation Gastroenterology. Liver. Pancreas. Abdomen General aspects Hemoglobin Hemoglobins - analysis Intestinal Ischemia Intestines - blood supply Ischemia Ischemia - blood Ischemia - diagnosis Liver Liver - physiology Mathematical analysis Medical sciences Occlusion Other diseases. Semiology Oxygen Consumption - physiology Oxygen content Oxygenation Oxyhemoglobins - analysis Paired Wilcoxon Test Parameters Peripheral Oxygen Saturation Rabbits Reperfusion Reproducibility of Results Small intestine Spectroscopy Spectrum Analysis - methods Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Superior Mesenteric Artery Tissues |
| title | Use of the Liver Tissue Oxygenation Index as a Noninvasive Parameter of Intestinal Ischemia in Rabbits |
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