Conductive Keratoplasty: Histological Study of Human Corneas
To determine the morphologic changes in human corneas over time following radiofrequency-based conductive keratoplasty (CK) treatment. Prospective, observational case series. In a single-center study six human corneas of six patients with localized peripheral keratoconus underwent CK treatment follo...
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| Veröffentlicht in: | American journal of ophthalmology 2005-12, Vol.140 (6), p.984-992.e2 |
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| creator | Naoumidi, Tatiana L. Pallikaris, Ioannis G. Naoumidi, Irini I. Astyrakakis, Nikolaos I. |
| description | To determine the morphologic changes in human corneas over time following radiofrequency-based conductive keratoplasty (CK) treatment.
Prospective, observational case series.
In a single-center study six human corneas of six patients with localized peripheral keratoconus underwent CK treatment followed by penetrating keratoplasty. Three spots were applied in the periphery of each cornea (6 mm optical zone). Corneal buttons were examined with light and electron microscopy at different postoperative intervals up to 6 months post-CK.
In samples assessed on day one post-CK, small areas of detachment between the basal layer of epithelial cells and Bowman’s layer were observed. At 1 week after the CK procedure, the epithelium appeared almost normal. Endothelium and Descemet’s membrane had no alterations. In all samples, thermally induced misconfiguration of collagen fibers, described as “crumpled” changes of collagen layers, was observed reaching 75% to 80% of the stromal depth. The area of alterations had a cylindrical shape with a diameter of 120 μm.
The conductive keratoplasty procedure produced collagen “crumpling and splitting” changes in human corneas, which were observed during the follow-up of 6 months. Areas adjacent to treatment site were minimally damaged. |
| doi_str_mv | 10.1016/j.ajo.2005.06.027 |
| format | Article |
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Prospective, observational case series.
In a single-center study six human corneas of six patients with localized peripheral keratoconus underwent CK treatment followed by penetrating keratoplasty. Three spots were applied in the periphery of each cornea (6 mm optical zone). Corneal buttons were examined with light and electron microscopy at different postoperative intervals up to 6 months post-CK.
In samples assessed on day one post-CK, small areas of detachment between the basal layer of epithelial cells and Bowman’s layer were observed. At 1 week after the CK procedure, the epithelium appeared almost normal. Endothelium and Descemet’s membrane had no alterations. In all samples, thermally induced misconfiguration of collagen fibers, described as “crumpled” changes of collagen layers, was observed reaching 75% to 80% of the stromal depth. The area of alterations had a cylindrical shape with a diameter of 120 μm.
The conductive keratoplasty procedure produced collagen “crumpling and splitting” changes in human corneas, which were observed during the follow-up of 6 months. Areas adjacent to treatment site were minimally damaged.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/j.ajo.2005.06.027</identifier><identifier>PMID: 16376640</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Collagen ; Collagen - metabolism ; Collagen - ultrastructure ; Corneal Stroma - metabolism ; Corneal Stroma - surgery ; Corneal Stroma - ultrastructure ; Electrocoagulation - methods ; Female ; Humans ; Keratoconus - metabolism ; Keratoconus - pathology ; Keratoconus - surgery ; Keratoplasty, Penetrating ; Male ; Medical sciences ; Microscopy ; Middle Aged ; Miscellaneous ; Ophthalmology ; Prospective Studies ; Studies ; Temperature ; Wound healing</subject><ispartof>American journal of ophthalmology, 2005-12, Vol.140 (6), p.984-992.e2</ispartof><rights>2005 Elsevier Inc.</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Elsevier Limited Dec 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-d05e05a7ae03cdce71cdd93b6f9b536cf079ed868596a607ffba53bced8ce46f3</citedby><cites>FETCH-LOGICAL-c409t-d05e05a7ae03cdce71cdd93b6f9b536cf079ed868596a607ffba53bced8ce46f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajo.2005.06.027$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17426552$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16376640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Naoumidi, Tatiana L.</creatorcontrib><creatorcontrib>Pallikaris, Ioannis G.</creatorcontrib><creatorcontrib>Naoumidi, Irini I.</creatorcontrib><creatorcontrib>Astyrakakis, Nikolaos I.</creatorcontrib><title>Conductive Keratoplasty: Histological Study of Human Corneas</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>To determine the morphologic changes in human corneas over time following radiofrequency-based conductive keratoplasty (CK) treatment.
Prospective, observational case series.
In a single-center study six human corneas of six patients with localized peripheral keratoconus underwent CK treatment followed by penetrating keratoplasty. Three spots were applied in the periphery of each cornea (6 mm optical zone). Corneal buttons were examined with light and electron microscopy at different postoperative intervals up to 6 months post-CK.
In samples assessed on day one post-CK, small areas of detachment between the basal layer of epithelial cells and Bowman’s layer were observed. At 1 week after the CK procedure, the epithelium appeared almost normal. Endothelium and Descemet’s membrane had no alterations. In all samples, thermally induced misconfiguration of collagen fibers, described as “crumpled” changes of collagen layers, was observed reaching 75% to 80% of the stromal depth. The area of alterations had a cylindrical shape with a diameter of 120 μm.
The conductive keratoplasty procedure produced collagen “crumpling and splitting” changes in human corneas, which were observed during the follow-up of 6 months. Areas adjacent to treatment site were minimally damaged.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Collagen</subject><subject>Collagen - metabolism</subject><subject>Collagen - ultrastructure</subject><subject>Corneal Stroma - metabolism</subject><subject>Corneal Stroma - surgery</subject><subject>Corneal Stroma - ultrastructure</subject><subject>Electrocoagulation - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Keratoconus - metabolism</subject><subject>Keratoconus - pathology</subject><subject>Keratoconus - surgery</subject><subject>Keratoplasty, Penetrating</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Ophthalmology</subject><subject>Prospective Studies</subject><subject>Studies</subject><subject>Temperature</subject><subject>Wound healing</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFq3DAQhkVpabZJH6CXYCjpzc7IlqVV2ktY2m5IIIckZyFLoyDjtTaSHdi3j5JdCPTQ0zDDN8M_HyHfKFQUKD_vK92HqgZoK-AV1OIDWdClkCVdSvqRLACgLmUj2RH5klKfWy6Y-EyOKG8E5wwW5NcqjHY2k3_G4hqjnsJ20GnaXRRrn6YwhEdv9FDcTbPdFcEV63mjx2IV4og6nZBPTg8Jvx7qMXn48_t-tS5vbv9erS5vSsNATqWFFqHVQiM0xhoU1Fgrm4472bUNNw6ERLvky1ZyzUE41-m26UyeGWTcNcfkx_7uNoanGdOkNj4ZHAY9YpiT4hJYLdo6g9__AfswxzFnU5QzJqmsaZMpuqdMDClFdGob_UbHnaKgXsWqXmWx6lWsAq6y2Lxzerg8dxu07xsHkxk4OwA6ZWMu6tH49M4JVvP2LeLPPYdZ2LPHqJLxOOZnfUQzKRv8f2K8ACUKlWQ</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>Naoumidi, Tatiana L.</creator><creator>Pallikaris, Ioannis G.</creator><creator>Naoumidi, Irini I.</creator><creator>Astyrakakis, Nikolaos I.</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20051201</creationdate><title>Conductive Keratoplasty: Histological Study of Human Corneas</title><author>Naoumidi, Tatiana L. ; Pallikaris, Ioannis G. ; Naoumidi, Irini I. ; Astyrakakis, Nikolaos I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-d05e05a7ae03cdce71cdd93b6f9b536cf079ed868596a607ffba53bced8ce46f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Collagen</topic><topic>Collagen - metabolism</topic><topic>Collagen - ultrastructure</topic><topic>Corneal Stroma - metabolism</topic><topic>Corneal Stroma - surgery</topic><topic>Corneal Stroma - ultrastructure</topic><topic>Electrocoagulation - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Keratoconus - metabolism</topic><topic>Keratoconus - pathology</topic><topic>Keratoconus - surgery</topic><topic>Keratoplasty, Penetrating</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Ophthalmology</topic><topic>Prospective Studies</topic><topic>Studies</topic><topic>Temperature</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Naoumidi, Tatiana L.</creatorcontrib><creatorcontrib>Pallikaris, Ioannis G.</creatorcontrib><creatorcontrib>Naoumidi, Irini I.</creatorcontrib><creatorcontrib>Astyrakakis, Nikolaos I.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naoumidi, Tatiana L.</au><au>Pallikaris, Ioannis G.</au><au>Naoumidi, Irini I.</au><au>Astyrakakis, Nikolaos I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conductive Keratoplasty: Histological Study of Human Corneas</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2005-12-01</date><risdate>2005</risdate><volume>140</volume><issue>6</issue><spage>984</spage><epage>992.e2</epage><pages>984-992.e2</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>To determine the morphologic changes in human corneas over time following radiofrequency-based conductive keratoplasty (CK) treatment.
Prospective, observational case series.
In a single-center study six human corneas of six patients with localized peripheral keratoconus underwent CK treatment followed by penetrating keratoplasty. Three spots were applied in the periphery of each cornea (6 mm optical zone). Corneal buttons were examined with light and electron microscopy at different postoperative intervals up to 6 months post-CK.
In samples assessed on day one post-CK, small areas of detachment between the basal layer of epithelial cells and Bowman’s layer were observed. At 1 week after the CK procedure, the epithelium appeared almost normal. Endothelium and Descemet’s membrane had no alterations. In all samples, thermally induced misconfiguration of collagen fibers, described as “crumpled” changes of collagen layers, was observed reaching 75% to 80% of the stromal depth. The area of alterations had a cylindrical shape with a diameter of 120 μm.
The conductive keratoplasty procedure produced collagen “crumpling and splitting” changes in human corneas, which were observed during the follow-up of 6 months. Areas adjacent to treatment site were minimally damaged.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16376640</pmid><doi>10.1016/j.ajo.2005.06.027</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Collagen Collagen - metabolism Collagen - ultrastructure Corneal Stroma - metabolism Corneal Stroma - surgery Corneal Stroma - ultrastructure Electrocoagulation - methods Female Humans Keratoconus - metabolism Keratoconus - pathology Keratoconus - surgery Keratoplasty, Penetrating Male Medical sciences Microscopy Middle Aged Miscellaneous Ophthalmology Prospective Studies Studies Temperature Wound healing |
| title | Conductive Keratoplasty: Histological Study of Human Corneas |
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