The evaluation and structure–activity relationships of 2-benzoylaminobenzoic esters and their analogues as anti-inflammatory and anti-platelet aggregation agents

A series of 2-benzoylaminobenzoic esters were synthesized and subjected to anti-platelet aggregation, inhibition of superoxide anion generation, and inhibition of neutrophil elastase release assays. Forty-seven 2-benzoylaminobenzoic esters were synthesized and evaluated in anti-platelet aggregation,...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-03, Vol.17 (6), p.1812-1817
Hauptverfasser:	Hsieh, Pei-Wen, Hwang, Tsong-Long, Wu, Chin-Chung, Chiang, Shin-Zan, Wu, Chung-I, Wu, Yang-Chang
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Benzoylaminobenzoic esters Anti-inflammatory Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-platelet aggregation agents Antioxidants - chemical synthesis Antioxidants - pharmacology Aspirin - pharmacology Benzoates - chemical synthesis Benzoates - pharmacology Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Bones, joints and connective tissue. Antiinflammatory agents Esters - chemical synthesis Esters - pharmacology Humans In Vitro Techniques Magnetic Resonance Spectroscopy Medical sciences Pharmacology. Drug treatments Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - chemical synthesis Platelet Aggregation Inhibitors - pharmacology Proteinase Inhibitory Proteins, Secretory - chemical synthesis Proteinase Inhibitory Proteins, Secretory - pharmacology Spectrometry, Mass, Electrospray Ionization Structure-Activity Relationship Superoxides - chemistry
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