Noninvasive prenatal diagnosis of β-thalassaemia using individual fetal erythroblasts isolated from maternal blood after enrichment

Single nucleated red blood cells (NRBCs) isolated from maternal circulation were used for prenatal diagnosis of β‐thalassaemia. The study included 22 pregnant women in the first trimester, 6 carriers at risk for β‐thalassaemia and 16 noncarriers. Methodology involved enrichment of NRBCs by magnetic...

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Veröffentlicht in:	Prenatal diagnosis 2007-12, Vol.27 (13), p.1228-1232
Hauptverfasser:	Kolialexi, A., Vrettou, C., Traeger-Synodinos, J., Burgemeister, R., Papantoniou, N., Kanavakis, E., Antsaklis, A., Mavrou, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Thalassemia - diagnosis beta-Thalassemia - genetics Biological and medical sciences Biomarkers - blood Delivery. Postpartum. Lactation DNA Fingerprinting Erythroblasts Female Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Genotype Globins - genetics Gynecology. Andrology. Obstetrics Humans Maternal-Fetal Exchange - genetics Medical sciences Microsatellite Repeats Molecular and cellular biology noninvasive prenatal diagnosis NRBCs Polymerase Chain Reaction Pregnancy Pregnancy Trimester, First Prenatal Diagnosis - methods single cell detachment β-thalassaemia
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