Herpes zoster in immunocompromised patients: Incidence, timing, and risk factors
To evaluate the risk factors for herpes zoster as well as the incidence and timing of this complication in patients who were treated with immunosuppression because of active Wegener’s granulomatosis. We studied the 180 Wegener’s granulomatosis patients in the Wegener’s Granulomatosis Etanercept Tria...
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| Veröffentlicht in: | The American journal of medicine 2005-12, Vol.118 (12), p.1416.e9-1416.e18 |
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| creator | Wung, Peter K. Holbrook, Janet T. Hoffman, Gary S. Tibbs, Andrea K. Specks, Ulrich Min, Y.-I. Merkel, Peter A. Spiera, Robert Davis, John C. St. Clair, E. William McCune, Joseph Ytterberg, Steven R. Allen, Nancy B. Stone, John H. |
| description | To evaluate the risk factors for herpes zoster as well as the incidence and timing of this complication in patients who were treated with immunosuppression because of active Wegener’s granulomatosis.
We studied the 180 Wegener’s granulomatosis patients in the Wegener’s Granulomatosis Etanercept Trial (WGET). Herpes zoster events during WGET were documented prospectively. Follow-up questionnaires were employed to describe the location, treatment, and complication(s) of herpes zoster and its therapy. Univariate and multivariate analyses were performed to evaluate risk factors, including history of herpes zoster, for the occurrence of herpes zoster during the trial. All analyses were based on the time to first occurrence of herpes zoster.
Eighteen patients (10% of the WGET cohort) suffered a total of 19 herpes zoster episodes over a mean follow-up period of 27 months. The annual incidence of herpes zoster in the WGET cohort was 45 cases/1000 patient-years (95% confidence interval [CI]: 27, 70). The median time from enrollment to the occurrence of herpes zoster in the subgroup of patients with that complication was 16.5 months (± 9.4). Fifteen of the 19 herpes zoster events (79%) occurred between months 6 and 36, many months after the period of most intensive immunosuppression. In univariate analyses, history of serum creatinine ≥1.5 mg/dL before enrollment was associated with a relative risk (RR) of 3.0 (95% CI: 1.1, 7.8) for herpes zoster during WGET (
P
=
.03). In multivariate analyses, serum creatinine ≥1.5 mg/dL was associated with an RR of 6.3 (95% CI: 2.0, 19.8;
P
=
.002), and female sex with an RR of 4.6 (95% CI: 1.6, 13.2;
P
=
.004).
Renal dysfunction and female sex were consistently strong risk factors for herpes zoster events in this population. Contrary to expectation, most herpes zoster events did not occur during periods of most intensive immunosuppression. These data may inform studies of interventions designed to prevent herpes zoster in patients on treatment for immune-mediated diseases. |
| doi_str_mv | 10.1016/j.amjmed.2005.06.012 |
| format | Article |
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We studied the 180 Wegener’s granulomatosis patients in the Wegener’s Granulomatosis Etanercept Trial (WGET). Herpes zoster events during WGET were documented prospectively. Follow-up questionnaires were employed to describe the location, treatment, and complication(s) of herpes zoster and its therapy. Univariate and multivariate analyses were performed to evaluate risk factors, including history of herpes zoster, for the occurrence of herpes zoster during the trial. All analyses were based on the time to first occurrence of herpes zoster.
Eighteen patients (10% of the WGET cohort) suffered a total of 19 herpes zoster episodes over a mean follow-up period of 27 months. The annual incidence of herpes zoster in the WGET cohort was 45 cases/1000 patient-years (95% confidence interval [CI]: 27, 70). The median time from enrollment to the occurrence of herpes zoster in the subgroup of patients with that complication was 16.5 months (± 9.4). Fifteen of the 19 herpes zoster events (79%) occurred between months 6 and 36, many months after the period of most intensive immunosuppression. In univariate analyses, history of serum creatinine ≥1.5 mg/dL before enrollment was associated with a relative risk (RR) of 3.0 (95% CI: 1.1, 7.8) for herpes zoster during WGET (
P
=
.03). In multivariate analyses, serum creatinine ≥1.5 mg/dL was associated with an RR of 6.3 (95% CI: 2.0, 19.8;
P
=
.002), and female sex with an RR of 4.6 (95% CI: 1.6, 13.2;
P
=
.004).
Renal dysfunction and female sex were consistently strong risk factors for herpes zoster events in this population. Contrary to expectation, most herpes zoster events did not occur during periods of most intensive immunosuppression. These data may inform studies of interventions designed to prevent herpes zoster in patients on treatment for immune-mediated diseases.</description><identifier>ISSN: 0002-9343</identifier><identifier>EISSN: 1555-7162</identifier><identifier>DOI: 10.1016/j.amjmed.2005.06.012</identifier><identifier>PMID: 16378799</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Etanercept ; Female ; Granulomatosis with Polyangiitis - drug therapy ; Herpes zoster ; Herpes Zoster - epidemiology ; Herpes Zoster - etiology ; Humans ; Immunocompromised Host ; Immunoglobulin G - adverse effects ; Immunoglobulin G - therapeutic use ; Immunosuppression ; Immunosuppressive Agents - adverse effects ; Immunosuppressive Agents - therapeutic use ; Incidence ; Male ; Middle Aged ; Receptors, Tumor Necrosis Factor - therapeutic use ; Renal insufficiency ; Risk Factors ; Time Factors ; Wegener’s granulomatosis</subject><ispartof>The American journal of medicine, 2005-12, Vol.118 (12), p.1416.e9-1416.e18</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c275t-8ebc70e373556cd49c54939b29b239c216aebdbb939e0dae8c82027a6a99dbed3</citedby><cites>FETCH-LOGICAL-c275t-8ebc70e373556cd49c54939b29b239c216aebdbb939e0dae8c82027a6a99dbed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.amjmed.2005.06.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16378799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wung, Peter K.</creatorcontrib><creatorcontrib>Holbrook, Janet T.</creatorcontrib><creatorcontrib>Hoffman, Gary S.</creatorcontrib><creatorcontrib>Tibbs, Andrea K.</creatorcontrib><creatorcontrib>Specks, Ulrich</creatorcontrib><creatorcontrib>Min, Y.-I.</creatorcontrib><creatorcontrib>Merkel, Peter A.</creatorcontrib><creatorcontrib>Spiera, Robert</creatorcontrib><creatorcontrib>Davis, John C.</creatorcontrib><creatorcontrib>St. Clair, E. William</creatorcontrib><creatorcontrib>McCune, Joseph</creatorcontrib><creatorcontrib>Ytterberg, Steven R.</creatorcontrib><creatorcontrib>Allen, Nancy B.</creatorcontrib><creatorcontrib>Stone, John H.</creatorcontrib><creatorcontrib>WGET Research Group</creatorcontrib><title>Herpes zoster in immunocompromised patients: Incidence, timing, and risk factors</title><title>The American journal of medicine</title><addtitle>Am J Med</addtitle><description>To evaluate the risk factors for herpes zoster as well as the incidence and timing of this complication in patients who were treated with immunosuppression because of active Wegener’s granulomatosis.
We studied the 180 Wegener’s granulomatosis patients in the Wegener’s Granulomatosis Etanercept Trial (WGET). Herpes zoster events during WGET were documented prospectively. Follow-up questionnaires were employed to describe the location, treatment, and complication(s) of herpes zoster and its therapy. Univariate and multivariate analyses were performed to evaluate risk factors, including history of herpes zoster, for the occurrence of herpes zoster during the trial. All analyses were based on the time to first occurrence of herpes zoster.
Eighteen patients (10% of the WGET cohort) suffered a total of 19 herpes zoster episodes over a mean follow-up period of 27 months. The annual incidence of herpes zoster in the WGET cohort was 45 cases/1000 patient-years (95% confidence interval [CI]: 27, 70). The median time from enrollment to the occurrence of herpes zoster in the subgroup of patients with that complication was 16.5 months (± 9.4). Fifteen of the 19 herpes zoster events (79%) occurred between months 6 and 36, many months after the period of most intensive immunosuppression. In univariate analyses, history of serum creatinine ≥1.5 mg/dL before enrollment was associated with a relative risk (RR) of 3.0 (95% CI: 1.1, 7.8) for herpes zoster during WGET (
P
=
.03). In multivariate analyses, serum creatinine ≥1.5 mg/dL was associated with an RR of 6.3 (95% CI: 2.0, 19.8;
P
=
.002), and female sex with an RR of 4.6 (95% CI: 1.6, 13.2;
P
=
.004).
Renal dysfunction and female sex were consistently strong risk factors for herpes zoster events in this population. Contrary to expectation, most herpes zoster events did not occur during periods of most intensive immunosuppression. These data may inform studies of interventions designed to prevent herpes zoster in patients on treatment for immune-mediated diseases.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Etanercept</subject><subject>Female</subject><subject>Granulomatosis with Polyangiitis - drug therapy</subject><subject>Herpes zoster</subject><subject>Herpes Zoster - epidemiology</subject><subject>Herpes Zoster - etiology</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>Immunoglobulin G - adverse effects</subject><subject>Immunoglobulin G - therapeutic use</subject><subject>Immunosuppression</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Incidence</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Receptors, Tumor Necrosis Factor - therapeutic use</subject><subject>Renal insufficiency</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Wegener’s granulomatosis</subject><issn>0002-9343</issn><issn>1555-7162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotn78A5GcPHXXSbLJNh4EEbWCoAc9h2wyldTubk22gv56U1o8CgPDzLzz9RByxqBkwNTlorTtokVfcgBZgiqB8T0yZlLKomaK75MxAPBCi0qMyFFKixyCluqQjJgS9bTWekxeZhhXmOhPnwaMNHQ0tO26613frmLfhoSeruwQsBvSFX3sXPDYOZzQIbShe59Q23kaQ_qgc-uGPqYTcjC3y4SnO39M3u7vXm9nxdPzw-PtzVPheC2HYoqNqwFFLaRUzlfayUoL3fBsQjvOlMXGN03OIXiLUzflwGurrNa-QS-OycV2bj7zc41pMPlYh8ul7bBfJ6M0VMAEy8JqK3SxTyni3KxiaG38NgzMhqRZmC1JsyFpQJlMMred7-avm03tr2mHLguutwLMX34FjCa5sGHjQ0Q3GN-H_zf8Aub3h10</recordid><startdate>200512</startdate><enddate>200512</enddate><creator>Wung, Peter K.</creator><creator>Holbrook, Janet T.</creator><creator>Hoffman, Gary S.</creator><creator>Tibbs, Andrea K.</creator><creator>Specks, Ulrich</creator><creator>Min, Y.-I.</creator><creator>Merkel, Peter A.</creator><creator>Spiera, Robert</creator><creator>Davis, John C.</creator><creator>St. Clair, E. William</creator><creator>McCune, Joseph</creator><creator>Ytterberg, Steven R.</creator><creator>Allen, Nancy B.</creator><creator>Stone, John H.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200512</creationdate><title>Herpes zoster in immunocompromised patients: Incidence, timing, and risk factors</title><author>Wung, Peter K. ; Holbrook, Janet T. ; Hoffman, Gary S. ; Tibbs, Andrea K. ; Specks, Ulrich ; Min, Y.-I. ; Merkel, Peter A. ; Spiera, Robert ; Davis, John C. ; St. Clair, E. William ; McCune, Joseph ; Ytterberg, Steven R. ; Allen, Nancy B. ; Stone, John H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c275t-8ebc70e373556cd49c54939b29b239c216aebdbb939e0dae8c82027a6a99dbed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Etanercept</topic><topic>Female</topic><topic>Granulomatosis with Polyangiitis - drug therapy</topic><topic>Herpes zoster</topic><topic>Herpes Zoster - epidemiology</topic><topic>Herpes Zoster - etiology</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>Immunoglobulin G - adverse effects</topic><topic>Immunoglobulin G - therapeutic use</topic><topic>Immunosuppression</topic><topic>Immunosuppressive Agents - adverse effects</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Incidence</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Receptors, Tumor Necrosis Factor - therapeutic use</topic><topic>Renal insufficiency</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Wegener’s granulomatosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wung, Peter K.</creatorcontrib><creatorcontrib>Holbrook, Janet T.</creatorcontrib><creatorcontrib>Hoffman, Gary S.</creatorcontrib><creatorcontrib>Tibbs, Andrea K.</creatorcontrib><creatorcontrib>Specks, Ulrich</creatorcontrib><creatorcontrib>Min, Y.-I.</creatorcontrib><creatorcontrib>Merkel, Peter A.</creatorcontrib><creatorcontrib>Spiera, Robert</creatorcontrib><creatorcontrib>Davis, John C.</creatorcontrib><creatorcontrib>St. Clair, E. William</creatorcontrib><creatorcontrib>McCune, Joseph</creatorcontrib><creatorcontrib>Ytterberg, Steven R.</creatorcontrib><creatorcontrib>Allen, Nancy B.</creatorcontrib><creatorcontrib>Stone, John H.</creatorcontrib><creatorcontrib>WGET Research Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wung, Peter K.</au><au>Holbrook, Janet T.</au><au>Hoffman, Gary S.</au><au>Tibbs, Andrea K.</au><au>Specks, Ulrich</au><au>Min, Y.-I.</au><au>Merkel, Peter A.</au><au>Spiera, Robert</au><au>Davis, John C.</au><au>St. Clair, E. William</au><au>McCune, Joseph</au><au>Ytterberg, Steven R.</au><au>Allen, Nancy B.</au><au>Stone, John H.</au><aucorp>WGET Research Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Herpes zoster in immunocompromised patients: Incidence, timing, and risk factors</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>2005-12</date><risdate>2005</risdate><volume>118</volume><issue>12</issue><spage>1416.e9</spage><epage>1416.e18</epage><pages>1416.e9-1416.e18</pages><issn>0002-9343</issn><eissn>1555-7162</eissn><abstract>To evaluate the risk factors for herpes zoster as well as the incidence and timing of this complication in patients who were treated with immunosuppression because of active Wegener’s granulomatosis.
We studied the 180 Wegener’s granulomatosis patients in the Wegener’s Granulomatosis Etanercept Trial (WGET). Herpes zoster events during WGET were documented prospectively. Follow-up questionnaires were employed to describe the location, treatment, and complication(s) of herpes zoster and its therapy. Univariate and multivariate analyses were performed to evaluate risk factors, including history of herpes zoster, for the occurrence of herpes zoster during the trial. All analyses were based on the time to first occurrence of herpes zoster.
Eighteen patients (10% of the WGET cohort) suffered a total of 19 herpes zoster episodes over a mean follow-up period of 27 months. The annual incidence of herpes zoster in the WGET cohort was 45 cases/1000 patient-years (95% confidence interval [CI]: 27, 70). The median time from enrollment to the occurrence of herpes zoster in the subgroup of patients with that complication was 16.5 months (± 9.4). Fifteen of the 19 herpes zoster events (79%) occurred between months 6 and 36, many months after the period of most intensive immunosuppression. In univariate analyses, history of serum creatinine ≥1.5 mg/dL before enrollment was associated with a relative risk (RR) of 3.0 (95% CI: 1.1, 7.8) for herpes zoster during WGET (
P
=
.03). In multivariate analyses, serum creatinine ≥1.5 mg/dL was associated with an RR of 6.3 (95% CI: 2.0, 19.8;
P
=
.002), and female sex with an RR of 4.6 (95% CI: 1.6, 13.2;
P
=
.004).
Renal dysfunction and female sex were consistently strong risk factors for herpes zoster events in this population. Contrary to expectation, most herpes zoster events did not occur during periods of most intensive immunosuppression. These data may inform studies of interventions designed to prevent herpes zoster in patients on treatment for immune-mediated diseases.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16378799</pmid><doi>10.1016/j.amjmed.2005.06.012</doi><tpages>1</tpages></addata></record> |
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| ispartof | The American journal of medicine, 2005-12, Vol.118 (12), p.1416.e9-1416.e18 |
| issn | 0002-9343 1555-7162 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Etanercept Female Granulomatosis with Polyangiitis - drug therapy Herpes zoster Herpes Zoster - epidemiology Herpes Zoster - etiology Humans Immunocompromised Host Immunoglobulin G - adverse effects Immunoglobulin G - therapeutic use Immunosuppression Immunosuppressive Agents - adverse effects Immunosuppressive Agents - therapeutic use Incidence Male Middle Aged Receptors, Tumor Necrosis Factor - therapeutic use Renal insufficiency Risk Factors Time Factors Wegener’s granulomatosis |
| title | Herpes zoster in immunocompromised patients: Incidence, timing, and risk factors |
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