Normal HLA class I, II, and MICA gene distribution in uveal melanoma
The molecules of the HLA class I and II molecules as well as the MHC class I chain-related gene A (MICA), a polymorphic and stress-induced cell surface molecule, are involved in T-cell and natural killer-cell (NK-cell) mediated immune responses. In this study we looked for any genetic susceptibility...
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| Veröffentlicht in: | Molecular vision 2005-12, Vol.11, p.1166-1172 |
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| container_title | Molecular vision |
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| creator | Metzelaar-Blok, J A W Hurks, H M H Naipal, A De Lange, P Keunen, J E E Claas, F H J Doxiadis, I I N Jager, M J |
| description | The molecules of the HLA class I and II molecules as well as the MHC class I chain-related gene A (MICA), a polymorphic and stress-induced cell surface molecule, are involved in T-cell and natural killer-cell (NK-cell) mediated immune responses. In this study we looked for any genetic susceptibility contributed by HLA class I, class II, or MICA genes with regard to the development of uveal melanoma.
Between 1998 and 2001, 159 uveal melanoma patients were typed for HLA class I and II, and 168 uveal melanoma patients were evaluated for MICA by microsatellite typing. The HLA antigen and MICA allele frequencies were compared with control groups of, respectively, 2,440 and 247 healthy Dutch individuals.
HLA class I, HLA class II, and MICA gene frequencies in uveal melanoma patients and healthy Dutch controls showed no significant deviations after correction for the number of comparisons.
We conclude that there is no genetic susceptibility or increased risk attributed to any HLA class I, class II, and MICA polymorphism with regard to the development of uveal melanoma. |
| format | Article |
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Between 1998 and 2001, 159 uveal melanoma patients were typed for HLA class I and II, and 168 uveal melanoma patients were evaluated for MICA by microsatellite typing. The HLA antigen and MICA allele frequencies were compared with control groups of, respectively, 2,440 and 247 healthy Dutch individuals.
HLA class I, HLA class II, and MICA gene frequencies in uveal melanoma patients and healthy Dutch controls showed no significant deviations after correction for the number of comparisons.
We conclude that there is no genetic susceptibility or increased risk attributed to any HLA class I, class II, and MICA polymorphism with regard to the development of uveal melanoma.</description><identifier>EISSN: 1090-0535</identifier><identifier>PMID: 16379028</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; DNA Mutational Analysis ; Female ; Gene Expression Regulation, Neoplastic ; Gene Frequency ; Genes, MHC Class I - physiology ; Genes, MHC Class II - physiology ; Genotype ; Histocompatibility Antigens Class I - genetics ; Histocompatibility Antigens Class II - genetics ; Histocompatibility Testing ; Humans ; Male ; Melanoma - genetics ; Middle Aged ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Uveal Neoplasms - genetics</subject><ispartof>Molecular vision, 2005-12, Vol.11, p.1166-1172</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16379028$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Metzelaar-Blok, J A W</creatorcontrib><creatorcontrib>Hurks, H M H</creatorcontrib><creatorcontrib>Naipal, A</creatorcontrib><creatorcontrib>De Lange, P</creatorcontrib><creatorcontrib>Keunen, J E E</creatorcontrib><creatorcontrib>Claas, F H J</creatorcontrib><creatorcontrib>Doxiadis, I I N</creatorcontrib><creatorcontrib>Jager, M J</creatorcontrib><title>Normal HLA class I, II, and MICA gene distribution in uveal melanoma</title><title>Molecular vision</title><addtitle>Mol Vis</addtitle><description>The molecules of the HLA class I and II molecules as well as the MHC class I chain-related gene A (MICA), a polymorphic and stress-induced cell surface molecule, are involved in T-cell and natural killer-cell (NK-cell) mediated immune responses. In this study we looked for any genetic susceptibility contributed by HLA class I, class II, or MICA genes with regard to the development of uveal melanoma.
Between 1998 and 2001, 159 uveal melanoma patients were typed for HLA class I and II, and 168 uveal melanoma patients were evaluated for MICA by microsatellite typing. The HLA antigen and MICA allele frequencies were compared with control groups of, respectively, 2,440 and 247 healthy Dutch individuals.
HLA class I, HLA class II, and MICA gene frequencies in uveal melanoma patients and healthy Dutch controls showed no significant deviations after correction for the number of comparisons.
We conclude that there is no genetic susceptibility or increased risk attributed to any HLA class I, class II, and MICA polymorphism with regard to the development of uveal melanoma.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Child</subject><subject>DNA Mutational Analysis</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene Frequency</subject><subject>Genes, MHC Class I - physiology</subject><subject>Genes, MHC Class II - physiology</subject><subject>Genotype</subject><subject>Histocompatibility Antigens Class I - genetics</subject><subject>Histocompatibility Antigens Class II - genetics</subject><subject>Histocompatibility Testing</subject><subject>Humans</subject><subject>Male</subject><subject>Melanoma - genetics</subject><subject>Middle Aged</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Uveal Neoplasms - genetics</subject><issn>1090-0535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j01LxDAYhIMg7rr6FyQnTxbeJE2aHpf1YwtVL3ou-XhXIk1bm1bw31vc9TDMZeZh5oysGZSQgRRyRS5T-gTgTObFBVkxJYoSuF6T-5d-jKal-3pLXWtSotUdrRaZztPnarelH9gh9SFNY7DzFPqOho7O37iUIram66O5IucH0ya8PvmGvD8-vO32Wf36tCDqbOBQTtlBSqa1cIwzgdKCt8ZqWUAOyNCrUmPJNHiujTC5lU4pCSAEz52T1gslNuT2yB3G_mvGNDUxJIftsgL7OTWqXFjwF7w5BWcb0TfDGKIZf5r_3-IXtORP_w</recordid><startdate>20051221</startdate><enddate>20051221</enddate><creator>Metzelaar-Blok, J A W</creator><creator>Hurks, H M H</creator><creator>Naipal, A</creator><creator>De Lange, P</creator><creator>Keunen, J E E</creator><creator>Claas, F H J</creator><creator>Doxiadis, I I N</creator><creator>Jager, M J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20051221</creationdate><title>Normal HLA class I, II, and MICA gene distribution in uveal melanoma</title><author>Metzelaar-Blok, J A W ; Hurks, H M H ; Naipal, A ; De Lange, P ; Keunen, J E E ; Claas, F H J ; Doxiadis, I I N ; Jager, M J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-f551883c1213e5b0dbab857040e1ed698e9180d28a3a4b5c665003324cc5bd363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Child</topic><topic>DNA Mutational Analysis</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene Frequency</topic><topic>Genes, MHC Class I - physiology</topic><topic>Genes, MHC Class II - physiology</topic><topic>Genotype</topic><topic>Histocompatibility Antigens Class I - genetics</topic><topic>Histocompatibility Antigens Class II - genetics</topic><topic>Histocompatibility Testing</topic><topic>Humans</topic><topic>Male</topic><topic>Melanoma - genetics</topic><topic>Middle Aged</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Uveal Neoplasms - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Metzelaar-Blok, J A W</creatorcontrib><creatorcontrib>Hurks, H M H</creatorcontrib><creatorcontrib>Naipal, A</creatorcontrib><creatorcontrib>De Lange, P</creatorcontrib><creatorcontrib>Keunen, J E E</creatorcontrib><creatorcontrib>Claas, F H J</creatorcontrib><creatorcontrib>Doxiadis, I I N</creatorcontrib><creatorcontrib>Jager, M J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular vision</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Metzelaar-Blok, J A W</au><au>Hurks, H M H</au><au>Naipal, A</au><au>De Lange, P</au><au>Keunen, J E E</au><au>Claas, F H J</au><au>Doxiadis, I I N</au><au>Jager, M J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Normal HLA class I, II, and MICA gene distribution in uveal melanoma</atitle><jtitle>Molecular vision</jtitle><addtitle>Mol Vis</addtitle><date>2005-12-21</date><risdate>2005</risdate><volume>11</volume><spage>1166</spage><epage>1172</epage><pages>1166-1172</pages><eissn>1090-0535</eissn><abstract>The molecules of the HLA class I and II molecules as well as the MHC class I chain-related gene A (MICA), a polymorphic and stress-induced cell surface molecule, are involved in T-cell and natural killer-cell (NK-cell) mediated immune responses. In this study we looked for any genetic susceptibility contributed by HLA class I, class II, or MICA genes with regard to the development of uveal melanoma.
Between 1998 and 2001, 159 uveal melanoma patients were typed for HLA class I and II, and 168 uveal melanoma patients were evaluated for MICA by microsatellite typing. The HLA antigen and MICA allele frequencies were compared with control groups of, respectively, 2,440 and 247 healthy Dutch individuals.
HLA class I, HLA class II, and MICA gene frequencies in uveal melanoma patients and healthy Dutch controls showed no significant deviations after correction for the number of comparisons.
We conclude that there is no genetic susceptibility or increased risk attributed to any HLA class I, class II, and MICA polymorphism with regard to the development of uveal melanoma.</abstract><cop>United States</cop><pmid>16379028</pmid><tpages>7</tpages></addata></record> |
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| ispartof | Molecular vision, 2005-12, Vol.11, p.1166-1172 |
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| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Aged Aged, 80 and over Child DNA Mutational Analysis Female Gene Expression Regulation, Neoplastic Gene Frequency Genes, MHC Class I - physiology Genes, MHC Class II - physiology Genotype Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class II - genetics Histocompatibility Testing Humans Male Melanoma - genetics Middle Aged Polymerase Chain Reaction Polymorphism, Genetic Uveal Neoplasms - genetics |
| title | Normal HLA class I, II, and MICA gene distribution in uveal melanoma |
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