Combined use of the JAK3 inhibitor CP-690,550 with mycophenolate mofetil to prevent kidney allograft rejection in nonhuman primates

Immunosuppression via Janus kinase (JAK) 3 inhibition affords significant prolongation of allograft survival. We investigated the effects of an immunosuppressive regimen combining the JAK3 inhibitor CP-690,550 with mycophenolate mofetil (MMF) in nonhuman primates (NHPs). Life-supporting kidney trans...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Transplantation 2005-12, Vol.80 (12), p.1756-1764
Hauptverfasser:	BORIE, Dominic C, LARSON, Michael J, ELLIOTT, Eileen A, REITZ, Bruce A, CHANGELIAN, Paul S, FLORES, Mona G, CAMPBELL, Andrew, ROUSVOAL, Geraldine, ZHANG, Sally, HIGGINS, John P, BALL, Douglas J, KUDLACZ, Elizabeth M, BRISSETTE, William H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Survival - drug effects Janus Kinase 3 Kidney Transplantation - immunology Macaca fascicularis Medical sciences Models, Animal Mycophenolic Acid - analogs & derivatives Mycophenolic Acid - therapeutic use Piperidines Primates Protein Kinase Inhibitors - therapeutic use Protein-Tyrosine Kinases - metabolism Pyrimidines - therapeutic use Pyrroles - therapeutic use Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!