Analysis of Specific Transcriptional Regulators as Early Predictors of Independent Prognostic Relevance in Resected Colorectal Cancer
Purpose: Prognostic studies on transcription factors acting at specific promoter elements have never been done so far. However, in tumors with long necessary follow-up, such as colorectal cancer, early-risk predictors would be needed. The invasion-related gene u-PAR is regulated via an activator pro...
Gespeichert in:
| Veröffentlicht in: | Clinical cancer research 2007-02, Vol.13 (4), p.1123-1132 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1132 |
|---|---|
| container_issue | 4 |
| container_start_page | 1123 |
| container_title | Clinical cancer research |
| container_volume | 13 |
| creator | Maurer, Gabriele D Leupold, Joerg H Schewe, Denis M Biller, Tobias Kates, Ronald E Hornung, Hans-Martin Lau-Werner, Ulla Post, Stefan Allgayer, Heike |
| description | Purpose: Prognostic studies on transcription factors acting at specific promoter elements have never been done so far. However, in
tumors with long necessary follow-up, such as colorectal cancer, early-risk predictors would be needed. The invasion-related
gene u-PAR is regulated via an activator protein 2 (AP-2)/Sp1 (−152/−135) and an AP-1 binding promoter motif (−190/−171), mediating
u-PAR induction by K-Ras and Src. The present study was done to give first evidence for early prognostic relevance of transcription
factors differentially bound to the u-PAR promoter, and their molecular inducers, in colorectal cancer.
Experimental Design: Tumor/normal tissues of 92 prospectively followed (median = 26.3 months) patients were analyzed for Src activity/protein,
K-ras mutations, and transcription factor binding to both u-PAR promoter motifs ( in vivo gel shift, kinase assay, and PCR).
Results: Kaplan-Meier/Mantel-Cox analysis showed a significant correlation among elevated Sp1/Sp3 binding to region −152/−135 ( P = 0.002 and P = 0.006), the combinations of Sp1/AP-2 and Sp1/AP-1 binding to both motifs ( P = 0.010 and P = 0.005), and Sp1 binding/high Src protein in tumors ( P < 0.001), with poor survival. Survival decreased with the number of bound transcription factors to both motifs, with binding
of three factors defining a high-risk group ( P = 0.021). In multivariate analysis, elevated Sp1 binding, combinations of Sp1/AP-2 binding and Sp1/AP-1 binding, or Sp1 binding/high
Src were independent prognostic variables; u-PAR expression itself being not yet prognostic. A first molecular staging model
(CART) was defined, providing novel early high-risk groups (mean survival time as low as for non-curatively resected patients)
from these variables.
Conclusions: This study defines transcription factors acting at specific promoter elements of an invasion-related gene, mediating specific
signaling, as novel, independent, early predictors of prognosis in colorectal cancer. |
| doi_str_mv | 10.1158/1078-0432.CCR-06-1668 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69038986</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69038986</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-f9ac20a4994381909a161fc9ef3bd7173f35611154badb974949ce17e9ae198f3</originalsourceid><addsrcrecordid>eNpFkc2OFCEQgDtG4_7oI2i4aPbSK9XQPxw3nVU32UQzrmfC0MUMhmla6FkzD-B7W70zZi9QUF8V8FEU74BfA9TdJ-BtV3Ipquu-X5W8KaFpuhfFOdR1W4qqqV9S_J85Ky5y_sU5SODydXEGrYC2q_h58fdmNOGQfWbRsR8TWu-8ZQ_JjNkmP80-Up6tcLMPZo4pM5PZrUnhwL4nHLx92qPSu3HACWkYZ8rEzRjzTI1WGPDRjBaZH2mR0c44sD6GmCikzv2STG-KV86EjG9P82Xx8_PtQ_-1vP_25a6_uS-thHYunTK24kYqJUUHiisDDTir0In10NKjnKgbID1ybYa1aqWSyiK0qAyC6py4LD4e-04p_t5jnvXOZ4shmBHjPutGcdGpriGwPoI2xZwTOj0lvzPpoIHrxb9e3OrFrSb_mjd68U91708H7Nc7HJ6rTsIJ-HACTLYmOBJtfX7mupbTNwFxV0du6zfbPz6htk-mEjk0yW41CC3pJpUQ_wDJEZ3v</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69038986</pqid></control><display><type>article</type><title>Analysis of Specific Transcriptional Regulators as Early Predictors of Independent Prognostic Relevance in Resected Colorectal Cancer</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Maurer, Gabriele D ; Leupold, Joerg H ; Schewe, Denis M ; Biller, Tobias ; Kates, Ronald E ; Hornung, Hans-Martin ; Lau-Werner, Ulla ; Post, Stefan ; Allgayer, Heike</creator><creatorcontrib>Maurer, Gabriele D ; Leupold, Joerg H ; Schewe, Denis M ; Biller, Tobias ; Kates, Ronald E ; Hornung, Hans-Martin ; Lau-Werner, Ulla ; Post, Stefan ; Allgayer, Heike</creatorcontrib><description>Purpose: Prognostic studies on transcription factors acting at specific promoter elements have never been done so far. However, in
tumors with long necessary follow-up, such as colorectal cancer, early-risk predictors would be needed. The invasion-related
gene u-PAR is regulated via an activator protein 2 (AP-2)/Sp1 (−152/−135) and an AP-1 binding promoter motif (−190/−171), mediating
u-PAR induction by K-Ras and Src. The present study was done to give first evidence for early prognostic relevance of transcription
factors differentially bound to the u-PAR promoter, and their molecular inducers, in colorectal cancer.
Experimental Design: Tumor/normal tissues of 92 prospectively followed (median = 26.3 months) patients were analyzed for Src activity/protein,
K-ras mutations, and transcription factor binding to both u-PAR promoter motifs ( in vivo gel shift, kinase assay, and PCR).
Results: Kaplan-Meier/Mantel-Cox analysis showed a significant correlation among elevated Sp1/Sp3 binding to region −152/−135 ( P = 0.002 and P = 0.006), the combinations of Sp1/AP-2 and Sp1/AP-1 binding to both motifs ( P = 0.010 and P = 0.005), and Sp1 binding/high Src protein in tumors ( P < 0.001), with poor survival. Survival decreased with the number of bound transcription factors to both motifs, with binding
of three factors defining a high-risk group ( P = 0.021). In multivariate analysis, elevated Sp1 binding, combinations of Sp1/AP-2 binding and Sp1/AP-1 binding, or Sp1 binding/high
Src were independent prognostic variables; u-PAR expression itself being not yet prognostic. A first molecular staging model
(CART) was defined, providing novel early high-risk groups (mean survival time as low as for non-curatively resected patients)
from these variables.
Conclusions: This study defines transcription factors acting at specific promoter elements of an invasion-related gene, mediating specific
signaling, as novel, independent, early predictors of prognosis in colorectal cancer.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>DOI: 10.1158/1078-0432.CCR-06-1668</identifier><identifier>PMID: 17317820</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Antineoplastic agents ; Biological and medical sciences ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - surgery ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastrointestinal cancers: colorectal ; Genes, ras ; Genes, src ; Humans ; Male ; Medical sciences ; Molecular Oncology ; Mutation ; Pharmacology. Drug treatments ; Prognosis ; Promoter Regions, Genetic ; Receptors, Cell Surface - genetics ; Receptors, Cell Surface - metabolism ; Receptors, Urokinase Plasminogen Activator ; Sp1 Transcription Factor - genetics ; Sp1 Transcription Factor - metabolism ; src-Family Kinases - genetics ; src-Family Kinases - metabolism ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Survival Rate ; Transcription Factor AP-1 - genetics ; Transcription Factor AP-1 - metabolism ; Transcription Factor AP-2 - genetics ; Transcription Factor AP-2 - metabolism ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Transcription, Genetic ; Tumor staging: correlation of clinical and molecular markers ; Tumors</subject><ispartof>Clinical cancer research, 2007-02, Vol.13 (4), p.1123-1132</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-f9ac20a4994381909a161fc9ef3bd7173f35611154badb974949ce17e9ae198f3</citedby><cites>FETCH-LOGICAL-c417t-f9ac20a4994381909a161fc9ef3bd7173f35611154badb974949ce17e9ae198f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18700011$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17317820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maurer, Gabriele D</creatorcontrib><creatorcontrib>Leupold, Joerg H</creatorcontrib><creatorcontrib>Schewe, Denis M</creatorcontrib><creatorcontrib>Biller, Tobias</creatorcontrib><creatorcontrib>Kates, Ronald E</creatorcontrib><creatorcontrib>Hornung, Hans-Martin</creatorcontrib><creatorcontrib>Lau-Werner, Ulla</creatorcontrib><creatorcontrib>Post, Stefan</creatorcontrib><creatorcontrib>Allgayer, Heike</creatorcontrib><title>Analysis of Specific Transcriptional Regulators as Early Predictors of Independent Prognostic Relevance in Resected Colorectal Cancer</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Purpose: Prognostic studies on transcription factors acting at specific promoter elements have never been done so far. However, in
tumors with long necessary follow-up, such as colorectal cancer, early-risk predictors would be needed. The invasion-related
gene u-PAR is regulated via an activator protein 2 (AP-2)/Sp1 (−152/−135) and an AP-1 binding promoter motif (−190/−171), mediating
u-PAR induction by K-Ras and Src. The present study was done to give first evidence for early prognostic relevance of transcription
factors differentially bound to the u-PAR promoter, and their molecular inducers, in colorectal cancer.
Experimental Design: Tumor/normal tissues of 92 prospectively followed (median = 26.3 months) patients were analyzed for Src activity/protein,
K-ras mutations, and transcription factor binding to both u-PAR promoter motifs ( in vivo gel shift, kinase assay, and PCR).
Results: Kaplan-Meier/Mantel-Cox analysis showed a significant correlation among elevated Sp1/Sp3 binding to region −152/−135 ( P = 0.002 and P = 0.006), the combinations of Sp1/AP-2 and Sp1/AP-1 binding to both motifs ( P = 0.010 and P = 0.005), and Sp1 binding/high Src protein in tumors ( P < 0.001), with poor survival. Survival decreased with the number of bound transcription factors to both motifs, with binding
of three factors defining a high-risk group ( P = 0.021). In multivariate analysis, elevated Sp1 binding, combinations of Sp1/AP-2 binding and Sp1/AP-1 binding, or Sp1 binding/high
Src were independent prognostic variables; u-PAR expression itself being not yet prognostic. A first molecular staging model
(CART) was defined, providing novel early high-risk groups (mean survival time as low as for non-curatively resected patients)
from these variables.
Conclusions: This study defines transcription factors acting at specific promoter elements of an invasion-related gene, mediating specific
signaling, as novel, independent, early predictors of prognosis in colorectal cancer.</description><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastrointestinal cancers: colorectal</subject><subject>Genes, ras</subject><subject>Genes, src</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular Oncology</subject><subject>Mutation</subject><subject>Pharmacology. Drug treatments</subject><subject>Prognosis</subject><subject>Promoter Regions, Genetic</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Receptors, Urokinase Plasminogen Activator</subject><subject>Sp1 Transcription Factor - genetics</subject><subject>Sp1 Transcription Factor - metabolism</subject><subject>src-Family Kinases - genetics</subject><subject>src-Family Kinases - metabolism</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Survival Rate</subject><subject>Transcription Factor AP-1 - genetics</subject><subject>Transcription Factor AP-1 - metabolism</subject><subject>Transcription Factor AP-2 - genetics</subject><subject>Transcription Factor AP-2 - metabolism</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Transcription, Genetic</subject><subject>Tumor staging: correlation of clinical and molecular markers</subject><subject>Tumors</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc2OFCEQgDtG4_7oI2i4aPbSK9XQPxw3nVU32UQzrmfC0MUMhmla6FkzD-B7W70zZi9QUF8V8FEU74BfA9TdJ-BtV3Ipquu-X5W8KaFpuhfFOdR1W4qqqV9S_J85Ky5y_sU5SODydXEGrYC2q_h58fdmNOGQfWbRsR8TWu-8ZQ_JjNkmP80-Up6tcLMPZo4pM5PZrUnhwL4nHLx92qPSu3HACWkYZ8rEzRjzTI1WGPDRjBaZH2mR0c44sD6GmCikzv2STG-KV86EjG9P82Xx8_PtQ_-1vP_25a6_uS-thHYunTK24kYqJUUHiisDDTir0In10NKjnKgbID1ybYa1aqWSyiK0qAyC6py4LD4e-04p_t5jnvXOZ4shmBHjPutGcdGpriGwPoI2xZwTOj0lvzPpoIHrxb9e3OrFrSb_mjd68U91708H7Nc7HJ6rTsIJ-HACTLYmOBJtfX7mupbTNwFxV0du6zfbPz6htk-mEjk0yW41CC3pJpUQ_wDJEZ3v</recordid><startdate>20070215</startdate><enddate>20070215</enddate><creator>Maurer, Gabriele D</creator><creator>Leupold, Joerg H</creator><creator>Schewe, Denis M</creator><creator>Biller, Tobias</creator><creator>Kates, Ronald E</creator><creator>Hornung, Hans-Martin</creator><creator>Lau-Werner, Ulla</creator><creator>Post, Stefan</creator><creator>Allgayer, Heike</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070215</creationdate><title>Analysis of Specific Transcriptional Regulators as Early Predictors of Independent Prognostic Relevance in Resected Colorectal Cancer</title><author>Maurer, Gabriele D ; Leupold, Joerg H ; Schewe, Denis M ; Biller, Tobias ; Kates, Ronald E ; Hornung, Hans-Martin ; Lau-Werner, Ulla ; Post, Stefan ; Allgayer, Heike</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-f9ac20a4994381909a161fc9ef3bd7173f35611154badb974949ce17e9ae198f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gastrointestinal cancers: colorectal</topic><topic>Genes, ras</topic><topic>Genes, src</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular Oncology</topic><topic>Mutation</topic><topic>Pharmacology. Drug treatments</topic><topic>Prognosis</topic><topic>Promoter Regions, Genetic</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Receptors, Urokinase Plasminogen Activator</topic><topic>Sp1 Transcription Factor - genetics</topic><topic>Sp1 Transcription Factor - metabolism</topic><topic>src-Family Kinases - genetics</topic><topic>src-Family Kinases - metabolism</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Survival Rate</topic><topic>Transcription Factor AP-1 - genetics</topic><topic>Transcription Factor AP-1 - metabolism</topic><topic>Transcription Factor AP-2 - genetics</topic><topic>Transcription Factor AP-2 - metabolism</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Transcription, Genetic</topic><topic>Tumor staging: correlation of clinical and molecular markers</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maurer, Gabriele D</creatorcontrib><creatorcontrib>Leupold, Joerg H</creatorcontrib><creatorcontrib>Schewe, Denis M</creatorcontrib><creatorcontrib>Biller, Tobias</creatorcontrib><creatorcontrib>Kates, Ronald E</creatorcontrib><creatorcontrib>Hornung, Hans-Martin</creatorcontrib><creatorcontrib>Lau-Werner, Ulla</creatorcontrib><creatorcontrib>Post, Stefan</creatorcontrib><creatorcontrib>Allgayer, Heike</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maurer, Gabriele D</au><au>Leupold, Joerg H</au><au>Schewe, Denis M</au><au>Biller, Tobias</au><au>Kates, Ronald E</au><au>Hornung, Hans-Martin</au><au>Lau-Werner, Ulla</au><au>Post, Stefan</au><au>Allgayer, Heike</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of Specific Transcriptional Regulators as Early Predictors of Independent Prognostic Relevance in Resected Colorectal Cancer</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2007-02-15</date><risdate>2007</risdate><volume>13</volume><issue>4</issue><spage>1123</spage><epage>1132</epage><pages>1123-1132</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>Purpose: Prognostic studies on transcription factors acting at specific promoter elements have never been done so far. However, in
tumors with long necessary follow-up, such as colorectal cancer, early-risk predictors would be needed. The invasion-related
gene u-PAR is regulated via an activator protein 2 (AP-2)/Sp1 (−152/−135) and an AP-1 binding promoter motif (−190/−171), mediating
u-PAR induction by K-Ras and Src. The present study was done to give first evidence for early prognostic relevance of transcription
factors differentially bound to the u-PAR promoter, and their molecular inducers, in colorectal cancer.
Experimental Design: Tumor/normal tissues of 92 prospectively followed (median = 26.3 months) patients were analyzed for Src activity/protein,
K-ras mutations, and transcription factor binding to both u-PAR promoter motifs ( in vivo gel shift, kinase assay, and PCR).
Results: Kaplan-Meier/Mantel-Cox analysis showed a significant correlation among elevated Sp1/Sp3 binding to region −152/−135 ( P = 0.002 and P = 0.006), the combinations of Sp1/AP-2 and Sp1/AP-1 binding to both motifs ( P = 0.010 and P = 0.005), and Sp1 binding/high Src protein in tumors ( P < 0.001), with poor survival. Survival decreased with the number of bound transcription factors to both motifs, with binding
of three factors defining a high-risk group ( P = 0.021). In multivariate analysis, elevated Sp1 binding, combinations of Sp1/AP-2 binding and Sp1/AP-1 binding, or Sp1 binding/high
Src were independent prognostic variables; u-PAR expression itself being not yet prognostic. A first molecular staging model
(CART) was defined, providing novel early high-risk groups (mean survival time as low as for non-curatively resected patients)
from these variables.
Conclusions: This study defines transcription factors acting at specific promoter elements of an invasion-related gene, mediating specific
signaling, as novel, independent, early predictors of prognosis in colorectal cancer.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>17317820</pmid><doi>10.1158/1078-0432.CCR-06-1668</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1078-0432 |
| ispartof | Clinical cancer research, 2007-02, Vol.13 (4), p.1123-1132 |
| issn | 1078-0432 1557-3265 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69038986 |
| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Antineoplastic agents Biological and medical sciences Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - surgery Female Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal cancers: colorectal Genes, ras Genes, src Humans Male Medical sciences Molecular Oncology Mutation Pharmacology. Drug treatments Prognosis Promoter Regions, Genetic Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, Urokinase Plasminogen Activator Sp1 Transcription Factor - genetics Sp1 Transcription Factor - metabolism src-Family Kinases - genetics src-Family Kinases - metabolism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Rate Transcription Factor AP-1 - genetics Transcription Factor AP-1 - metabolism Transcription Factor AP-2 - genetics Transcription Factor AP-2 - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Tumor staging: correlation of clinical and molecular markers Tumors |
| title | Analysis of Specific Transcriptional Regulators as Early Predictors of Independent Prognostic Relevance in Resected Colorectal Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T20%3A25%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Analysis%20of%20Specific%20Transcriptional%20Regulators%20as%20Early%20Predictors%20of%20Independent%20Prognostic%20Relevance%20in%20Resected%20Colorectal%20Cancer&rft.jtitle=Clinical%20cancer%20research&rft.au=Maurer,%20Gabriele%20D&rft.date=2007-02-15&rft.volume=13&rft.issue=4&rft.spage=1123&rft.epage=1132&rft.pages=1123-1132&rft.issn=1078-0432&rft.eissn=1557-3265&rft_id=info:doi/10.1158/1078-0432.CCR-06-1668&rft_dat=%3Cproquest_cross%3E69038986%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69038986&rft_id=info:pmid/17317820&rfr_iscdi=true |