Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS‐4 and ADAMTS‐5

Objective Recent published studies have shown that cartilage from ADAMTS‐5–knockout mice, but not ADAMTS‐4– or ADAMTS‐1–knockout mice, is significantly protected from degradation. The present study was undertaken to evaluate the respective roles of these enzymes in human cartilage breakdown, using a...

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Veröffentlicht in:	Arthritis and rheumatism 2007-02, Vol.56 (2), p.575-585
Hauptverfasser:	Song, Ruo‐Hua, D. Tortorella, Micky, Malfait, Anne‐Marie, Alston, James T., Yang, Zhiyong, Arner, Elizabeth C., Griggs, David W.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - genetics ADAM Proteins - metabolism ADAMTS1 Protein ADAMTS4 Protein ADAMTS5 Protein Adult Aged Aged, 80 and over Aggrecans - metabolism Biological and medical sciences Cartilage, Articular - cytology Cartilage, Articular - metabolism Cartilage, Articular - pathology Cells, Cultured Chondrocytes - cytology Chondrocytes - metabolism Chondrocytes - pathology Diseases of the osteoarticular system Gene Expression Regulation Gene Silencing Humans Male Medical sciences Middle Aged Miscellaneous. Osteoarticular involvement in other diseases Osteoarthritis Osteoarthritis - metabolism Osteoarthritis - pathology Procollagen N-Endopeptidase - genetics Procollagen N-Endopeptidase - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Transfection
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