The HLA–DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide

Objective The HLA shared epitope (SE) alleles are primarily a risk factor for the presence of antibodies to cyclic citrullinated peptide (anti‐CCP antibodies) rather than for the development of rheumatoid arthritis (RA). The SE alleles interact with the environmental risk factor tobacco exposure (TE...

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Veröffentlicht in:	Arthritis and rheumatism 2007-02, Vol.56 (2), p.425-432
Hauptverfasser:	van der Helm‐van Mil, Annette H. M., Verpoort, Kirsten N., le Cessie, Saskia, Huizinga, Tom W. J., de Vries, René R. P., Toes, René E. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alleles Antibodies - immunology Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - physiopathology Biological and medical sciences Cohort Studies Disease Progression Epitopes - genetics Epitopes - immunology Female Genetic Predisposition to Disease HLA-DR Antigens - genetics HLA-DR Antigens - immunology HLA-DRB1 Chains Humans Male Medical sciences Middle Aged Peptides, Cyclic - immunology Peptides, Cyclic - physiology Protein Binding Risk Factors Smoking - genetics Smoking - immunology Tobacco Products Tobacco, tobacco smoking Toxicology
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