Biologically Active Triterpenoid Saponins from Ardisia japonica
Eleven new triterpenoid saponins, ardisianosides A (1), B (2), C (4), D (5), E (6), F (7), G (15), H (16), I (17), J (18), and K (19), together with 10 known saponins, were isolated from the whole plants of Ardisia japonica. The structures of the new saponins were established on the basis of extensi...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2007-02, Vol.70 (2), p.179-187 |
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| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 70 |
| creator | Chang, Xiaolong Li, Wei Jia, Zhonghua Satou, Tadaaki Fushiya, Shinji Koike, Kazuo |
| description | Eleven new triterpenoid saponins, ardisianosides A (1), B (2), C (4), D (5), E (6), F (7), G (15), H (16), I (17), J (18), and K (19), together with 10 known saponins, were isolated from the whole plants of Ardisia japonica. The structures of the new saponins were established on the basis of extensive 1D and 2D NMR and MS studies coupled with chemical degradations. The cytotoxic activities of saponins 1−21 are reported against three human cancer cell lines, namely, HL-60 myeloid leukemia, KATO-III stomach adenocarcinoma, and A549 lung adenocarcinoma cells. |
| doi_str_mv | 10.1021/np0604681 |
| format | Article |
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The structures of the new saponins were established on the basis of extensive 1D and 2D NMR and MS studies coupled with chemical degradations. The cytotoxic activities of saponins 1−21 are reported against three human cancer cell lines, namely, HL-60 myeloid leukemia, KATO-III stomach adenocarcinoma, and A549 lung adenocarcinoma cells.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np0604681</identifier><identifier>PMID: 17243725</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>anticarcinogenic activity ; Antineoplastic Agents, Phytogenic - chemistry ; Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - pharmacology ; Ardisia ; Ardisia - chemistry ; Ardisia japonica ; ardisianoside ; Biological and medical sciences ; chemical structure ; cultured cells ; cytotoxicity ; Drug Screening Assays, Antitumor ; General pharmacology ; Humans ; Japan ; Medical sciences ; nuclear magnetic resonance spectroscopy ; Nuclear Magnetic Resonance, Biomolecular ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plants, Medicinal - chemistry ; Primulaceae ; Saponins - chemistry ; Saponins - isolation & purification ; Saponins - pharmacology ; spectral analysis ; traditional medicine ; Triterpenes - chemistry ; Triterpenes - isolation & purification ; Triterpenes - pharmacology ; triterpenoid saponins</subject><ispartof>Journal of natural products (Washington, D.C.), 2007-02, Vol.70 (2), p.179-187</ispartof><rights>Copyright © 2007 American Chemical Society and American Society of Pharmacognosy</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a471t-feed42f5e5f26a54a7d566050158523c88cc1eae934516b9dea0f29a6595af923</citedby><cites>FETCH-LOGICAL-a471t-feed42f5e5f26a54a7d566050158523c88cc1eae934516b9dea0f29a6595af923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np0604681$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np0604681$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18606592$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17243725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Xiaolong</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Jia, Zhonghua</creatorcontrib><creatorcontrib>Satou, Tadaaki</creatorcontrib><creatorcontrib>Fushiya, Shinji</creatorcontrib><creatorcontrib>Koike, Kazuo</creatorcontrib><title>Biologically Active Triterpenoid Saponins from Ardisia japonica</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>Eleven new triterpenoid saponins, ardisianosides A (1), B (2), C (4), D (5), E (6), F (7), G (15), H (16), I (17), J (18), and K (19), together with 10 known saponins, were isolated from the whole plants of Ardisia japonica. The structures of the new saponins were established on the basis of extensive 1D and 2D NMR and MS studies coupled with chemical degradations. The cytotoxic activities of saponins 1−21 are reported against three human cancer cell lines, namely, HL-60 myeloid leukemia, KATO-III stomach adenocarcinoma, and A549 lung adenocarcinoma cells.</description><subject>anticarcinogenic activity</subject><subject>Antineoplastic Agents, Phytogenic - chemistry</subject><subject>Antineoplastic Agents, Phytogenic - isolation & purification</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Ardisia</subject><subject>Ardisia - chemistry</subject><subject>Ardisia japonica</subject><subject>ardisianoside</subject><subject>Biological and medical sciences</subject><subject>chemical structure</subject><subject>cultured cells</subject><subject>cytotoxicity</subject><subject>Drug Screening Assays, Antitumor</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Japan</subject><subject>Medical sciences</subject><subject>nuclear magnetic resonance spectroscopy</subject><subject>Nuclear Magnetic Resonance, Biomolecular</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plants, Medicinal - chemistry</subject><subject>Primulaceae</subject><subject>Saponins - chemistry</subject><subject>Saponins - isolation & purification</subject><subject>Saponins - pharmacology</subject><subject>spectral analysis</subject><subject>traditional medicine</subject><subject>Triterpenes - chemistry</subject><subject>Triterpenes - isolation & purification</subject><subject>Triterpenes - pharmacology</subject><subject>triterpenoid saponins</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0EFP2zAUB3BrAo0CO-wLbLkMiUPGsx07zmlqq1E2IW1Sy9l6ODZyl8bBThF8-6WkohdOluyf_s_vT8hnCt8pMHrVdiChkIp-IBMqGOQSmDgiE6CS51zJ4oScprQGAA6V-EhOaMkKXjIxIT9mPjThwRtsmpdsanr_ZLNV9L2NnW2Dr7MldqH1bcpcDJtsGmufPGbr11uD5-TYYZPsp_15Ru6uf67mN_ntn8Wv-fQ2x6Kkfe6srQvmhBWOSRQFlrWQEgRQoQTjRiljqEVb8UJQeV_VFsGxCqWoBLqK8TNyMeZ2MTxuber1xidjmwZbG7ZJywq4YrCDlyM0MaQUrdNd9BuML5qC3rWl39oa7Jd96PZ-Y-uD3NczgG97gGloyEVsjU8HpyQMP9wNzUfnU2-f394x_tOy5KXQq79LXd0sZsvfUmkY_NfROwwaH-KQebdkQDlAqTgr5GEymqTXYRvbod13VvgPeT-Ulg</recordid><startdate>20070201</startdate><enddate>20070201</enddate><creator>Chang, Xiaolong</creator><creator>Li, Wei</creator><creator>Jia, Zhonghua</creator><creator>Satou, Tadaaki</creator><creator>Fushiya, Shinji</creator><creator>Koike, Kazuo</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070201</creationdate><title>Biologically Active Triterpenoid Saponins from Ardisia japonica</title><author>Chang, Xiaolong ; Li, Wei ; Jia, Zhonghua ; Satou, Tadaaki ; Fushiya, Shinji ; Koike, Kazuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a471t-feed42f5e5f26a54a7d566050158523c88cc1eae934516b9dea0f29a6595af923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>anticarcinogenic activity</topic><topic>Antineoplastic Agents, Phytogenic - chemistry</topic><topic>Antineoplastic Agents, Phytogenic - isolation & purification</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Ardisia</topic><topic>Ardisia - chemistry</topic><topic>Ardisia japonica</topic><topic>ardisianoside</topic><topic>Biological and medical sciences</topic><topic>chemical structure</topic><topic>cultured cells</topic><topic>cytotoxicity</topic><topic>Drug Screening Assays, Antitumor</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Japan</topic><topic>Medical sciences</topic><topic>nuclear magnetic resonance spectroscopy</topic><topic>Nuclear Magnetic Resonance, Biomolecular</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plants, Medicinal - chemistry</topic><topic>Primulaceae</topic><topic>Saponins - chemistry</topic><topic>Saponins - isolation & purification</topic><topic>Saponins - pharmacology</topic><topic>spectral analysis</topic><topic>traditional medicine</topic><topic>Triterpenes - chemistry</topic><topic>Triterpenes - isolation & purification</topic><topic>Triterpenes - pharmacology</topic><topic>triterpenoid saponins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Xiaolong</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Jia, Zhonghua</creatorcontrib><creatorcontrib>Satou, Tadaaki</creatorcontrib><creatorcontrib>Fushiya, Shinji</creatorcontrib><creatorcontrib>Koike, Kazuo</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Xiaolong</au><au>Li, Wei</au><au>Jia, Zhonghua</au><au>Satou, Tadaaki</au><au>Fushiya, Shinji</au><au>Koike, Kazuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biologically Active Triterpenoid Saponins from Ardisia japonica</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2007-02-01</date><risdate>2007</risdate><volume>70</volume><issue>2</issue><spage>179</spage><epage>187</epage><pages>179-187</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>Eleven new triterpenoid saponins, ardisianosides A (1), B (2), C (4), D (5), E (6), F (7), G (15), H (16), I (17), J (18), and K (19), together with 10 known saponins, were isolated from the whole plants of Ardisia japonica. The structures of the new saponins were established on the basis of extensive 1D and 2D NMR and MS studies coupled with chemical degradations. The cytotoxic activities of saponins 1−21 are reported against three human cancer cell lines, namely, HL-60 myeloid leukemia, KATO-III stomach adenocarcinoma, and A549 lung adenocarcinoma cells.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>17243725</pmid><doi>10.1021/np0604681</doi><tpages>9</tpages></addata></record> |
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| subjects | anticarcinogenic activity Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Ardisia Ardisia - chemistry Ardisia japonica ardisianoside Biological and medical sciences chemical structure cultured cells cytotoxicity Drug Screening Assays, Antitumor General pharmacology Humans Japan Medical sciences nuclear magnetic resonance spectroscopy Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Primulaceae Saponins - chemistry Saponins - isolation & purification Saponins - pharmacology spectral analysis traditional medicine Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology triterpenoid saponins |
| title | Biologically Active Triterpenoid Saponins from Ardisia japonica |
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